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71.
Many successful synthesis routes for producing different shapes of metallic nanostructures, including sphere, rod, cube, and hollow shapes, have been developed in the past few decades. Many applications using these nanostructures have been studied because the outstanding properties of the nanostructures are not exhibited by their bulk-state counterparts. This review paper reports some recent developments in clinical and biosensor applications. The first part focused on the synthesis methods of metallic nanostructures having various shapes along with their optical properties. The second and third part is an introduction of the gold nanoparticle assemblies and arrays, explaining the conjugation methods of metallic nanostructures with biological entities. The final part reviews on the recent bioanalytical applications using various shapes of metallic nanostructures. 相似文献
72.
Manas Chakrabarty Ajanta Mukherji Shiho Arima Yoshihiro Harigaya Guillaume Pilet 《Monatshefte für Chemie / Chemical Monthly》2009,50(2):189-197
Abstract Ninhydrin reacted expeditiously with thirteen active methylene compounds on montmorillonite K10 clay at room temperature to
furnish, in 5 min, a Knoevenagel condensate in one case, aldols in six cases, aldol-derived cyclic hemiketals in three cases,
and interesting products in the remaining three cases. Almost identical results were obtained, but faster, when the reactions
were carried out in water on steam-bath. The structures of two novel products were also confirmed by single-crystal X-ray
diffraction analysis.
Graphical abstract
相似文献
73.
Takayama K Koseki K Torikai K Tokuchi A Nakamura E Arakida Y Shimosaki Y Wake M Kouno T Horioka K Igarashi S Iwashita T Kawasaki A Kishiro J Sakuda M Sato H Shiho M Shirakata M Sueno T Toyama T Watanabe M Yamane I 《Physical review letters》2005,94(14):144801
A single rf bunch in the KEK proton synchrotron was accelerated with an induction acceleration method from the injection energy of 500 MeV to 5 GeV. 相似文献
74.
The Keggin heteropoly acid, silicotungstic acid, H4SiW12O40, has been demonstrated to be highly efficient for an expeditious, one-pot synthesis of 1-methyl-2-(hetero)arylbenzimidazoles from N-methyl-1,2-phenylenediamine and (hetero)aryl aldehydes in ethyl acetate at room temperature. The catalyst works equally well for N-phenyl-1,2-phenylenediamine. 相似文献
75.
Halogen bonding catalysis has recently gained increasing attention as a powerful tool to activate organic molecules. However, the variety of the catalyst structure has been quite limited so far. Herein, we report the first example of the use of an iodoalkyne as a halogen bond donor catalyst. By using an iodoalkyne bearing a pentafluorophenyl group as a catalyst, thioamides were efficiently activated and reacted with 2‐aminophenol to generate benzoxazoles in good yield. Mechanistic studies, including 13C NMR spectroscopic analysis and several control experiments, provided concrete evidence that this catalytic activation is based on halogen bonding. Thus, the results obtained in this study demonstrate that iodoalkynes can serve as a new scaffold for future development of halogen bonding catalysis. 相似文献
76.
The total synthesis of salinosporamide A has been achieved through enzymatic desymmetrization, diastereoselective aldol reaction, intramolecular aldol reaction, and intermolecular Reformatsky-type reaction followed by 1,4-reduction as key reactions. 相似文献
77.
A novel DNA detection technique using a gold nanoparticle array film electrode has been reported here. The gold nanoparticles molecularly linked with binder molecule (1,10‐decanedithiol) were separated 1.3 nm from each other, and the DNA conductivity change from single to double strand was measured by monitoring a voltage drop across the particles, between which a probe of a 12‐mer oligonucleotide was immobilized. In adding a complementary oligonucleotide on the nanoparticle film chip, an immediate decrease in the film resistance (ca. 1.4 Ω) due to a hybridization event occurred in a reproducible manner with this simple setup. In the paper, we have an interest in the primary sensing properties; effect of the film resistance on the sensor response, dependence of the resistance change on the DNA concentration, and the performance of the system for DNA detection including single nucleotide polymorphisms were described. 相似文献
78.
Hirohara S Obata M Ogata S Ohtsuki C Higashida S Ogura S Okura I Takenaka M Ono H Sugai Y Mikata Y Tanihara M Yano S 《Journal of photochemistry and photobiology. B, Biology》2005,78(1):7-15
Eight 5,10,15,20-tetrakis[3- or 4-(beta-D-glycopyranosyloxy)phenyl]chlorins were synthesized by means of the Whitlock method with diimide reduction and purified by reversed-phase thin layer chromatography (RP-TLC). All compounds were characterized by (1)H NMR spectroscopy, electron-spray ionization time-of-flight mass spectrometry (ESI-TOF MS), and UV-Vis spectroscopy. ESI-TOF MS could detect the 2H difference in molecular weight between a glycoconjugated chlorin and its corresponding porphyrin (i.e., 5,10,15,20-tetrakis[3- or 4-(beta-D-glycopyranosyloxy)phenyl]porphyrin). The cellular uptake of the eight chlorins was evaluated in HeLa cells. All glycoconjugated chlorins showed higher cellular uptake than tetraphenylporphyrin tetrasulfonic acid (TPPS), and 5,10,15,20-tetrakis[3-(beta-D-xylopyranosyloxy)phenyl]chlorin showed 50-fold higher uptake than TPPS. The photocytotoxicity of 5,10,15,20-tetrakis[3-(beta-D-glucopyranosyloxy)phenyl]chlorin, 5,10,15,20-tetrakis[3-(beta-D-xylopyranosyloxy)phenyl]chlorin and TPPS towards HeLa cells was examined at the concentration of 2x10(-7) M (mol/dm(3)). These photosensitizers had no cytotoxicity in the dark, but their photocytotoxicity decreased in the order of 5,10,15,20-tetrakis[3-(beta-D-glucopyranosyloxy)phenyl]chlorin>5,10,15,20-tetrakis[3-(beta-D-xylopyranosyloxy)phenyl]chlorin>TPPS. The results indicate that the photocytotoxicity is not related simply to cellular uptake. 相似文献
79.
Hiroyuki Takemura Katsuya Sako Tesuo Iwanaga Akane Tatsumi Yukako Mogami Hiromi Watanabe Miho Aoki Shiho Yûki Yuri Hayano Mirei Itaka 《Tetrahedron》2018,74(16):1991-2001
The one-pot reaction between bis(hydroxymethyl)phenol derivatives and diamines or triamines afforded novel azacalixarenes with bridged structures. Basket-type macrocycles of cone conformations, molecules that contained two aza[3.1.1.1]calixarene skeletons connected by a chain, or novel saucer-type azacalixarenes were obtained from the reaction. Structures of some of them were determined by crystallographic analyses. 相似文献
80.
Takuji Magata Saeka Nagano Takuya Endo Jun Kawaida Shiho Nagaoka Yoshimi Hirokawa Naoyoshi Maezaki 《Tetrahedron letters》2017,58(37):3628-3630
Methyl 2-[1-[(tert-butoxycarbonyl)amino]ethyl]-4-methyloxazole-5-carboxylate (1) was synthesized with high optical purity via a Pd–catalyzed amide coupling with vinyl triflate with subsequent oxazole formation. The latter reaction proceeds via bromination of an enamide with NBS and DBU-promoted cyclization. The oxazole subunit positional isomer in a macrocyclic azole peptide was obtained in a good yield without racemization. The scope and limitations of this reaction were also investigated. 相似文献