Evidence for a trianion intermediate in the metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid. Methodology and application to racemic 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives

The metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid (8) affording trianion 6 is presented and applied to the regioselective efficient construction of a series of 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives 3 that are potent pan-active inhibitors of antiapoptotic Bcl-2 family proteins.     

A comparative study of solid-silver and silver-shell nanodimers on surface plasmon resonances

We investigated numerically the scattering cross sections and near-field intensities of solid-silver and silver-shell (shell thickness d = 10 nm) nanodimers that interact with incident plane wave by the use of finite-element method with three-dimensional models. Results show that the silver-shell cases exhibit tunable surface plasmon resonances and its rotational effects can induce more surface plasmons in a wider range of wavelength that are not observed for the solid-silver cases with the same volume (1,046,666 nm³).