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Xiyuan Yu Dr. Wei Lin Dr. Qian Lai Juan Song Dr. Yilong Liu Dr. Rui Su Qi Niu Prof. Liu Yang Prof. Chaoyong Yang Dr. Huimin Zhang Prof. Zhi Zhu 《Angewandte Chemie (International ed. in English)》2023,62(17):e202301083
Unlike plant and microbial cells having cell walls, the outermost layer of mammalian cell is a delicate, two-layered structure of phospholipids with proteins embedded, which is susceptible to environmental changes. It is necessary to create an “armor” on cell surface to protect cell integrity. Here, we propose an A uto-assembled R esilient bioM imetic calcified OR naments (ARMOR) strategy driven by dual-aptamer-based hybridization chain reaction (HCR) and Ca2+ assisted calcification for selective cell protection. This co-recognition design enhances the selectivity and leverages robust in situ signal amplification by HCR to improve the sensitivity. The calcified shell is cogenerated by crosslinking the alginate-HCR product with Ca2+ ion. ARMOR has high efficiency for shielding cells from environmental assaults, which can be applied to circulating tumor cell (CTC) protection, isolation, and identification, maintaining the native state and intact genetic information for downstream analysis. 相似文献