Docking,Synthesis, Spectral Characterization,and Evaluation of In Vitro Antifungal Activity of Bis/Monophenyl‐1‐aryl‐1H‐tetrazole‐5‐carboxylate

Some novel compounds of bis/monophenyl‐1‐aryl‐1H‐tetrazole‐5‐carboxylate were synthesized by the equimolar reaction between bis/mono‐1‐aryl‐1H‐tetrazole and phenyl chloroformate in the presence of NaOH in dry tetrahydrofuran. The content was stirred for 4 h at room temperature. Structures of these synthesized compounds were characterized by IR, ¹H‐NMR, ¹³C‐NMR, and mass spectrometric methods. The in vitro antifungal activity study demonstrates that results of compounds 6g and 6h are excellent, 6e a comparatively good one, and other compounds are moderate. The C docker energy of compounds 6g and 6h were ?38.22 and ?32.62 kcal/mol and that of compound 6e was ?21.26 kcal/mol.     

Sonochemical synthesis of CuO nanostructures with different morphology

This paper describes a highly efficient and rapid approach of synthesizing different CuO nanostructures in aqueous solutions using ultrasound irradiation of copper(II) acetate with urea/sodium hydroxide in the presence of polyvinylpyrrolidone (PVP), as stabilizing polymer. Field emission scanning electron microscope images clearly indicate the formation of CuO quasi-spherical microarchitectures and long-straw like structure in the presence of urea and sodium hydroxide. Other characterization techniques such as TEM, XRD and XPS are also provided to support the formation of such structures. One of the reasons for the formation of such CuO nanostructures may be due to the formation of a polymer-metal complex with the stabilizing polymer (PVP).