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51.
Chanchal Kiran Thakur Rabin Neupane Chandrabose Karthikeyan Charles R. Ashby Jr. R. Jayachandra Babu Sai H. S. Boddu Amit K. Tiwari Narayana Subbiah Hari Narayana Moorthy 《Molecules (Basel, Switzerland)》2022,27(21)
Multiwalled carbon nanotubes (MWCNTs) are elongated, hollow cylindrical nanotubes made of sp2 carbon. MWCNTs have attracted significant attention in the area of drug delivery due to their high drug-loading capacity and large surface area. Furthermore, they can be linked to bioactive ligands molecules via covalent and noncovalent bonds that allow for the targeted delivery of anticancer drugs such as doxorubicin. The majority of methodologies reported for the functionalization of MWCNTs for drug delivery are quite complex and use expensive linkers and ligands. In the present study, we report a simple, cost-effective approach for functionalizing MWCNTs with the carbohydrate ligands, galactose (GA), mannose (MA) and lactose (LA), using lysine as a linker. The doxorubicin (Dox)-loaded functionalized MWCNTs were characterized using FT-IR, NMR, Raman, XRD and FE-SEM. The drug–loaded MWCNTs were evaluated for drug loading, drug release and cell toxicity in vitro, in breast cancer cells. The results indicated that the carbohydrate-modified lysinated MWCNTs had greater Dox loading capacity, compared to carboxylated MWCNTs (COOHMWCNTs) and lysinated MWCNTs (LyMWCNTs). In vitro drug release experiments indicated that the carbohydrate functionalized LyMWCNTs had higher Dox release at pH 5.0, compared to the physiological pH of 7.4, over 120 h, indicating that they are suitable candidates for targeting the tumor microenvironment as a result of their sustained release profile of Dox. Doxorubicin-loaded galactosylated MWCNTs (Dox-GAMWCNTs) and doxorubicin loaded mannosylated MWCNTs (Dox-MAMWCNTs) had greater anticancer efficacy and cellular uptake, compared to doxorubicin–loaded lactosylated MWCNTs (Dox-LAMWCNTs) and pure Dox, in MDA-MB231 and MCF7 breast cancer cells. However, neither the ligand conjugated multiwall blank carbon nanotubes (GAMWCNTs, MAMWCNTs and LAMWCNTs) nor the lysinated multiwalled blank carbon nanotubes produced significant toxicity in the normal cells. Our results suggest that sugar-tethered multiwalled carbon nanotubes, especially the galactosylated (Dox-GAMWCNTs) and mannosylated (Dox-MAMWCNTs) formulations, may be used to improve the targeted delivery of anticancer drugs to breast cancer cells. 相似文献
52.
Dharmendra Kashyap Manushree Tanwar Chanchal Rani Pranit Hemant Bagde Siddharth Singh Nidhi Varshney Vaishali Saini Amit Mishra Rajesh Kumar Hem Chandra Jha 《Journal of Raman spectroscopy : JRS》2024,55(5):549-565
Helicobacter pylori and Epstein–Barr Virus (EBV) are Group 1 carcinogens that can enhance gastric cancer progression. Bioactive substances extracted from plants can be effective therapeutic agents in cancer treatment. For example, Withania somnifera extract-WSE reduces the Gankyrin oncoprotein, which is upregulated in the presence of H. pylori and EBV. The various biochemical and metabolic changes upon 24 hrs post-infection followed by W. somnifera extract (WSE) treatment on gastric epithelial cells (AGS) can be studied using spectroscopic techniques. In the biomedical sciences, Raman and NMR spectroscopy have been extensively employed to interpret cellular alterations contributing to the onset of infection and the severity of gastric cancer. More specifically, alterations in cellular biochemical homeostasis are linked to the moieties of cholesterol, collagen, choline, carbohydrate, lipids, tyrosine, and phenylalanine. Further, we have found significantly elevated FWHM for carbohydrates, tumor associated protein, collagen, cholesterol, and cholesterol ester in the co-infection model. We also looked into the potential correlation between these molecules using molecular network analysis and found several related factors that can be modulated through biomolecular levels. These molecules are crucial in several physiological functions, including cell division, cell proliferation, apoptosis, necrosis, cell migration, and lipid transport. Our study paves the pathway to study H. pylori and EBV co-infection in human gastric epithelial cells and the therapeutic interventions of WSE in this scenario and highlights specific biomolecular alterations, which can be focused for further mechanistic investigations. 相似文献
53.
Dr. Chanchal Kumar Roy Syed Shaheen Shah Akter H. Reaz Sharmin Sultana Dr. Al-Nakib Chowdhury Dr. Shakhawat H. Firoz Dr. Md. Hasan Zahir Dr. Mohammed Ameen Ahmed Qasem Dr. Md. Abdul Aziz 《化学:亚洲杂志》2021,16(4):296-308
We demonstrate a facile efficient way to fabricate activated carbon nanosheets (ACNSs) consisting of hierarchical porous carbon materials. Simply heating banana leaves with K2CO3 produce ACNSs having a unique combination of macro-, meso- and micropores with a high specific surface area of ∼1459 m2 g−1. The effects of different electrolytes on the electrochemical supercapacitor performance and stability of the ACNSs are tested using a two-electrode system. The specific capacitance (Csp) values are 55, 114, and 190 F g−1 in aqueous 0.5 M sodium sulfate, organic 1 M tetraethylammonium tetrafluoroborate in acetonitrile, and pure ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF6]) electrolytes, respectively. The ACNSs also shows the largest potential window of 3.0 V, the highest specific energy (59 Wh kg−1) and specific power (750 W kg−1) in [BMIM][PF6]. A mini-prototype device is prepared to demonstrate the practicality of the ACNSs. 相似文献
54.
Deepta Chattapadhyay Sahabaj Mondal Santosh Kumar Dr. Debasish Haldar 《化学:亚洲杂志》2021,16(18):2723-2728
Aggregation-induced emission enhancement (AIEE) is an unusual phenomenon where luminophores show a higher photoluminescence efficiency in the aggregated and solid state. We report the design and synthesis of a series of luminophores 1 – 4 with imine functionality at 6 position of coumarin and studied their AIE propensities on self-assembly. The effect of the topology of the phenolic hydroxyl group on the emission behaviour of the luminophores has been investigated. The imines show significant solvatochromism with high emission in non-polar solvents, whereas the emission gets quenched in the polar solvent. The fluorescence in the toluene-hexane mixture arises due to the aggregation of fluorophores and falls under the category of AIEE. Not only the solution state emission of the isomeric iminocoumarin luminophores is notably varied, but also their solid-state emission found to be significantly different from each other. Moreover, the iminocoumarin 1 selectively recognizes Fe(III) over Fe(II) with a prominent color change. In situ oxidation of Fe(II) with H2O2 exhibits the same effect like Fe(III) and developed a chemical combinational logic gate. 相似文献
55.
The strong intermolecular interactions mediated by short hydrophobic sequences (e.g., 17-20, -l-Leu-l-Val-l-Phe-l-Phe-) in the middle of Aβ are known to play a crucial role in the neuropathology of Alzheimer's disease. FTIR, TEM and Congo red binding studies indicated that a series of l-Ala substituted terminally protected peptides related to the sequence 17-20 of the β-amyloid peptide, adopted β-sheet conformations. However, the Aib-modified analogues disrupt the β-sheet structure and switch over to a 310 helix with increasing number of Aib residues. X-ray crystallography shed some light on the change from sheet to helix at atomic resolution. 相似文献
56.
Ritesh Haldar Mariana Kozlowska Michael Ganschow Samrat Ghosh Marius Jakoby Hongye Chen Farhad Ghalami Weiwei Xie Shahriar Heidrich Yusuke Tsutsui Jan Freudenberg Shu Seki Ian A. Howard Bryce S. Richards Uwe H. F. Bunz Marcus Elstner Wolfgang Wenzel Christof Wll 《Chemical science》2021,12(12):4477
Charge carrier mobility is an important figure of merit to evaluate organic semiconductor (OSC) materials. In aggregated OSCs, this quantity is determined by inter-chromophoric electronic and vibrational coupling. These key parameters sensitively depend on structural properties, including the density of defects. We have employed a new type of crystalline assembly strategy to engineer the arrangement of the OSC pentacene in a structure not realized as crystals to date. Our approach is based on metal–organic frameworks (MOFs), in which suitably substituted pentacenes act as ditopic linkers and assemble into highly ordered π-stacks with long-range order. Layer-by-layer fabrication of the MOF yields arrays of electronically coupled pentacene chains, running parallel to the substrate surface. Detailed photophysical studies reveal strong, anisotropic inter-pentacene electronic coupling, leading to efficient charge delocalization. Despite a high degree of structural order and pronounced dispersion of the 1D-bands for the static arrangement, our experimental results demonstrate hopping-like charge transport with an activation energy of 64 meV dominating the band transport over a wide range of temperatures. A thorough combined quantum mechanical and molecular dynamics investigation identifies frustrated localized rotations of the pentacene cores as the reason for the breakdown of band transport and paves the way for a crystal engineering strategy of molecular OSCs that independently varies the arrangement of the molecular cores and their vibrational degrees of freedom.Pentacene assembled into 1D arrays using a metal–organic framework (MOF) approach. This cofacial packing motif, which is not present in pentacene bulk, shows an interesting interplay of band-like and hopping-type transport. 相似文献
57.
Ruthenium is extracted by benzyl alcohol from 5M LiCl containing ethyl-alpha-isonitrosoacetoacetate at pH 4-6. The extraction is quantitative if the solution is heated to boiling for 15 min. The benzyl alcohol extract shows maximum absorbance at 470 nm and at this wavelength Beer's law is obeyed over the ruthenium concentration range 0.1-1.8 mug ml . The error is 4% for 0.5 mug ml . 相似文献
58.
Pranab Haldar 《Tetrahedron》2007,63(14):3049-3056
A simple methodology for the conversion of substituted N-aryl-γ-lactam 2/3-carboxylic acids to substituted N-aryl-2/3-formyl-pyrroles has been developed. Several N-aryl-γ-lactam 2/3-carboxylic acids were reduced to substituted (N-aryl-pyrroliden-2/3-yl)-methanols in good yields by using the NaBH4-I2 system. Aromatisation and in situ oxidation of these alcohols using DDQ produced N-aryl-2/3-formyl-pyrroles, which act as key starting material and intermediates in the synthesis of several bioactive compounds. 相似文献
59.
60.
Sayan Biswas Amit Kar Joydeb Chanda Nanaocha Sharma Pardeep Kumar Bharadwaj Pallab Kanti Haldar Pulok Kumar Mukherjee 《Biomedical chromatography : BMC》2022,36(5):e5328
A rapid validated ultra-fast liquid chromatography–photodiode array detector (UFLC-PDA) method was developed to identify and quantify ayapanin (AY) and umbelliferone (UM) simultaneously in Ayapana triplinervis Vahl methanolic extract. The method was validated for linearity, limit of detection (LOD; 3:1σ/S), limit of quantification (LOQ; 10:1σ/S), precision, accuracy, specificity and robustness. The response was linear with a good correlation between concentration and mean peak area through a correlation coefficient of 0.9996, y = 7025.7x – 2269.8 and 0.9997, y = y = 16,262x – 946 with LOD of 6.256 ± 0.52 and 3.325 ± 0.36, and LOQ of 18.838 ± 0.18 and 8.870 ± 0.85 for AY (0.67% w/w) and UM (0.18% w/w), respectively. The relative standard deviation (%) of precision and recovery of AY and UM was <2.0%. The proposed method was simple, accurate, specific, precise and reproducible. 相似文献