排序方式: 共有107条查询结果,搜索用时 15 毫秒
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Paris E. Georghiou Celine Schneider Grigory Shamov Timothy D. Lash Shofiur Rahman D. Sabrina Giddings 《Supramolecular chemistry》2016,28(5-6):396-402
AbstractSolid-state NMR data are presented to clearly support the formation of a 1:1 supramolecular complex between C60 and the tetra-tert-butylated analogue of calix[4]azulene by a simple mechanochemical hand-grinding of host and guest in a mortar and pestle. The experimental results are supported by a DFT study. 相似文献
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Goujon C Thomas N Dalloz-Dubrujeaud B 《The European physical journal. E, Soft matter》2003,11(2):147-157
Recent studies have pointed out the importance of the
basal friction on the dynamics of granular flows. We present
experimental results on the influence of the roughness of the
inclined plane on the dynamics of a monodisperse dry granular
flow. We found experimentally that there exists a maximum of the
friction for a given relative roughness. This maximum is shown
to be independent of the slope angle. This behavior is observed
for four planes with different bump sizes (given by the size of
the beads glued on the plane) from 200 m to 2 mm. The relative
roughness corresponding to the maximum of the friction can be
predicted with a geometrical model of stability of one single
bead on the plane. The main parameters are the size of the bumps
and the size of the flowing beads. In order to obtain a higher
precision, the model also takes into account the spacing between
the bumps of the rough plane. Experimental results and model are
in good agreement for all the planes we studied. Other
parameters, like the sphericity of the beads, or irregularities
in the thickness of the layer of glued particles, are shown to
be of influence on the friction. 相似文献
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A series of 7-amino- and polyaminosterol analogues of squalamine and trodusquemine were synthesized involving a new stereoselective titanium reductive amination reaction in high chemical yields of up to 95% in numerous cases. These derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. All the compounds present excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with minimum inhibitory concentrations (MICs) varying from 2.5 to 10 μg/mL. Numerous derivatives possess also MICs against Gram-negative Escherichia coli bacteria (MICs varying from 2.5 to 10 μg/mL) suggesting that nature of the amino group attached to the sterol moiety plays an important role on the activities of such products. 相似文献
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Goverdhan Mehta Celine Le DroumaguetKabirul Islam Anakuthil AnoopEluvathingal D. Jemmis 《Tetrahedron letters》2003,44(15):3109-3113
π-Face selectivity in Diels-Alder reactions between specially crafted bicyclo[2.2.2]octane-fused benzoquinones, where the dienophilic moiety is imbedded in an isosteric environment, can be modulated by a remote olefinic bond and a cyclopropane ring. Quantum mechanical calculations while reproducing the observed diastereoselectivities at the TS level indicate the involvement of ground state orbital effects. 相似文献
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Dr. Francesco Zaccaria Dr. Stephanie C. C. van der Lubbe Celine Nieuwland Dr. Trevor A. Hamlin Prof. Dr. Célia Fonseca Guerra 《Chemphyschem》2021,22(22):2286-2296
The formation of guanine quadruplexes (GQ) in DNA is crucial in telomere homeostasis and regulation of gene expression. Pollution metals can interfere with these DNA superstructures upon coordination. In this work, we study the affinity of the internal GQ channel site towards alkaline earth metal (Mg2+, Ca2+, Sr2+, and Ba2+), and (post-)transition metal (Zn2+, Cd2+, Hg2+, and Pb2+) cations using density functional theory computations. We find that divalent cations generally bind to the GQ cavity with a higher affinity than conventional monovalent cations (e. g. K+). Importantly, we establish the nature of the cation-GQ interaction and highlight the relationship between ionic and nuclear charge, and the electrostatic and covalent interactions. The covalent interaction strength plays an important role in the cation affinity and can be traced back to the relative stabilization of cations’ unoccupied atomic orbitals. Overall, our findings contribute to a deeper understanding of how pollution metals could induce genomic instability. 相似文献
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Celine Zahradnik Claudia Kolm Roland Martzy Robert L. Mach Rudolf Krska Andreas H. Farnleitner Kurt Brunner 《Analytical and bioanalytical chemistry》2014,406(27):6835-6842
In 2003 the European Commission introduced a 0.9 % threshold for food and feed products containing genetically modified organism (GMO)-derived components. For commodities containing GMO contents higher than this threshold, labelling is mandatory. To provide a DNA-based rapid and simple detection method suitable for high-throughput screening of GMOs, several isothermal amplification approaches for the 35S promoter were tested: strand displacement amplification, nicking-enzyme amplification reaction, rolling circle amplification, loop-mediated isothermal amplification (LAMP) and helicase-dependent amplification (HDA). The assays developed were tested for specificity in order to distinguish between samples containing genetically modified (GM) maize and non-GM maize. For those assays capable of this discrimination, tests were performed to determine the lower limit of detection. A false-negative rate was determined to rule out whether GMO-positive samples were incorrectly classified as GMO-negative. A robustness test was performed to show reliable detection independent from the instrument used for amplification. The analysis of three GM maize lines showed that only LAMP and HDA were able to differentiate between the GMOs MON810, NK603, and Bt11 and non-GM maize. Furthermore, with the HDA assay it was possible to realize a detection limit as low as 0.5 %. A false-negative rate of only 5 % for 1 % GM maize for all three maize lines shows that HDA has the potential to be used as an alternative strategy for the detection of transgenic maize. All results obtained with the LAMP and HDA assays were compared with the results obtained with a previously reported real-time PCR assay for the 35S promoter in transgenic maize. This study presents two new screening assays for detection of the 35S promoter in transgenic maize by applying the isothermal amplification approaches HDA and LAMP. 相似文献