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81.
Tromp M van Bokhoven JA Arink AM Bitter JH van Koten G Koningsberger DC 《Chemistry (Weinheim an der Bergstrasse, Germany)》2002,8(24):5667-5678
Herein we describe a structural characterisation with EXAFS of copper(I) arenethiolate complexes in both the solid and liquid state. Previously noted difficulties in the detection of the Cu-Cu interaction have been attributed to anti-phase behaviour of different Cu-Cu neighbour contributions. A data analysis procedure solely based on EXAFS parameters is presented which resolves these problems. A careful analysis of the individual coordination shells and the use of different k-weightings during the data analysis are shown to be an absolute necessity to obtain reliable results. During R-space fitting, the difference file technique is used to separate, examine and compare the individual contributions. Using this technique their statistical significance and correctness can be determined. Anti-phase behaviour can be detected and accounted for in this way. An additional mixed organocopper aggregate [Cu4(SAr)2(Mes)2] with different Cu sites is analysed, which proves the value of the analysis procedure described above. Moreover, this newly developed EXAFS data analysis procedure is applicable to any other EXAFS spectrum obtained. The structural analysis of these organocopper complexes with EXAFS provides information about their actual structure and dynamic behaviour in solution. The technique can now be used to obtain insights into the reactivity of these complexes and the way in which they form catalytic reaction intermediates. 相似文献
82.
Catherine A. Evans 《Tetrahedron》2005,61(26):6309-6314
Amine-catalyzed coupling reactions of allenoate esters and α,β-unsaturated carbonyls lead to a diverse range of α,α′-disubstituted allenoates. With appropriately substituted monomers, intermolecular reactions can lead to pyrimidone products. Alternatively, with amine substituted allenoates, a 7-endo-dig cyclization can be carried out such that a divergent pathway is observed that leads to azepine scaffolds. 相似文献
83.
The study deals with the analysis of diffusion and mass transfer modelling during pervaporation in a true ternary system involving a polar liquid mixture (ETBE/EtOH) and a polar block copolymer (polyurethaneimide or PUI). A survey of methods of pervaporative transfer modelling in ternary systems is first developed. From differential permeation experiments carried out with both pure liquids, it appears that both permeants obey a Fickian law. Moreover, the diffusional behaviour is consistent with Long's model, which has thus been assumed for the related ternary system. An extension of the Brun's model is then derived, which takes into account the diffusion coupling as well the significant deviation from sorption ideality. From a practical point of view, the calculated values of fluxes show generally good agreement with the experimental results, although a small deviation occurs for mixtures of low ethanol content. Diffusion coefficients of both pure solvents corresponding to transient or steady state are compared. A very good agreement is found for the aprotic permeant (ETBE). whereas the diffusion coefficient of ethanol in transient state is only the quarter of the value corresponding to steady state. The results are discussed in comparison with related investigations in the literature, involving specific liquid-polymer interactions. 相似文献
84.
In neutral DMF, ellipticinium cations 9 R—E+H—2 CH3 undergo a reversible 1 e addition (standard potential ca. ?1.35 V) to yield a neutral radical which rapidly dimerizes (dimerization rate constant ca. 107 mol?1 1 s?1). In basic DMF or in the presence of superoxide anion, the corresponding conjugated bases undergo a reversible 1 e addition accompanied by a fast and reversible proton addition (standard potential at pHDMF 0 ca. ?0.52 V) to yield the same neutral radical. R being H, OCH3 or OH, there is no effect of the substituent at the C-9 position on the electrochemical process. 相似文献
85.
Halland N Alstrup Lie M Kjaersgaard A Marigo M Schiøtt B Jørgensen KA 《Chemistry (Weinheim an der Bergstrasse, Germany)》2005,11(23):7083-7090
The mechanism for the 2,5-diphenylpyrrolidine-catalyzed enantioselective alpha-chlorination of aldehydes with electrophilic halogenation reagents has been investigated by using experimental and computational methods. These studies have led us to propose a mechanism for the reaction that proceeds through an initial N-chlorination of the chiral catalyst-substrate complex, followed by a 1,3-sigmatropic shift of the chlorine atom to the enamine carbon atom. The suggested reaction course is different from previously proposed mechanisms for organocatalytic enamine reactions, in which the carbon-electrophile bond is formed directly. Furthermore, the rate-determining step in the overall reaction was determined and the presence of nonlinear effects was probed. 相似文献
86.
Chevelkov V van Rossum BJ Castellani F Rehbein K Diehl A Hohwy M Steuernagel S Engelke F Oschkinat H Reif B 《Journal of the American Chemical Society》2003,125(26):7788-7789
In this communication, we demonstrate the feasibility of 1H detection in MAS solid-state NMR for a microcrystalline, uniformly 2H,15N-labeled sample of a SH3 domain of chicken alpha-spectrin, using pulsed field gradients for suppression of water magnetization. Today, B0 gradients are employed routinely in solution-state NMR for coherence order selection and solvent suppression. We suggest to use gradients to purge water magnetization which cannot be suppressed using conventional water suppression schemes. The achievable gain in sensitivity for 1H detection is in the order of 5 compared to the 15N detected version of the experiment (at a MAS rotation frequency of 13.5 kHz). We expect that this labeling concept which achieves high sensitivity due to 1H detection, in combination with the possibility to measure long range 1H-1H distances as we have shown previously, to be a useful tool for the determination of protein structures in the solid state. 相似文献
87.
Atkinson CE Aliev AE Motherwell WB 《Chemistry (Weinheim an der Bergstrasse, Germany)》2003,9(8):1714-1723
A binding site optimisation protocol for the design of artificial enzymes based on "small molecule-small molecule" binding studies by diffusion NMR is presented. Since the reaction chosen was the hydrolysis of ester 1 ([4-(4-carboxy-1-oxobutyl)-aminobenzyl]-phenethyl ester), an analogous phosphonate ester 2 ([4-(4-carboxy-1-oxobutyl)-aminobenzyl]-phosphonic phenethyl ester) was selected as a suitable transition state analogue (TSA). The key objective of the NMR studies was to find a unit with functional groups capable of binding to the acidic sites of the TSA. Nine dipeptides, mainly with basic and hydroxyl groups, were used and their affinity to the TSA was studied by measuring the change in the diffusion coefficient, D(pep), upon binding by pulse field gradient NMR. The value of D(pep) at 298 K in D(2)O at pD 5, 7 and 10 was measured both in free solution, and mixtures containing one dipeptide and the TSA. As both components are low molecular weight species with M < 500, a TSA-to-dipeptide ratio of 10:1 was used to detect significant changes in D(pep). The results revealed that dipeptides with basic residues show higher affinity to the TSA than those with hydroxyl or aliphatic side chains in aqueous solutions. The dipeptide showing the most significant relative change in D(pep) was H-Arg-Arg-OH, and the binding constant was estimated to be 86 L M(-1) by measuring D(pep) at varying concentrations of the TSA. In addition, binding of the TSA to a new water-soluble polymer with a polyallylamine backbone and randomly distributed Arg-Arg binding sites was examined, and the binding constant was estimated to be > or =1500 L M(-1). As confirmed by further catalytic activity tests, polymers containing Arg-Arg as a binding site are capable of significant rate accelerations in the hydrolysis of ester 1. 相似文献
88.
Catherine Cloutour Caroline Debaig-Valade Catherine Gacherieu Jean-Claude Pommier 《Journal of organometallic chemistry》1984,269(3):239-247
A comparative study of alkylation by Grignard reagents of PSn(OH)2 (P = tetraphenylporphyrin (TPP), tetraphenylchlorine (TPC), tetraphenylisobacteriochlorine (TPiBC)) shows that dialkylstannylisobacteriochlorines are the most easily obtained. The presence of transition metals in the magnesium crystals directs the reaction towards reduction of the macrocycle instead of alkylation on tin. This is supplementary proof for the intervention of a single electron transfer mechanism (SET) in alkylation of a macrocycle by Grignard reagents.These results fit very well with earlier electrochemical experiments and the measurements of the reduction potentials of the Group IVB metalloporphyrins and their reduced forms. 相似文献
89.
Shongwe MS Kaschula CH Adsetts MS Ainscough EW Brodie AM Morris MJ 《Inorganic chemistry》2005,44(9):3070-3079
Three mononuclear ternary complexes of iron(III) with an alpha-diimine (bipy or phen) and a derivative of N,N-bis(2-hydroxybenzyl)glycinate (L3-) have been synthesized and characterized by magnetic susceptibility measurements, electron paramagnetic resonance (EPR) spectroscopy, vibrational spectroscopy, and electronic absorption spectroscopy. Single-crystal X-ray structure determinations of the pseudo-octahedral complexes [Fe(bipy)L] x MeCN [L = (3,5-Br2)-L3- or (5,3-Cl,Me)-L3-] revealed a considerable and consistent distortion in the coordination of bipy to iron(III) attributable largely to electronic effects. In both crystal structures, the Fe-N(pyridyl) bond trans to the phenolate oxygen is 0.133 A longer than the other one positioned trans to the tertiary amine nitrogen, a relatively weaker donor. This coordination behavior of bipy is of structural interest and has not been observed previously for iron(III). The electronic and EPR spectra of the compounds [Fe(L'-L')L] x MeCN (L'-L' = bipy or phen) are consistent with the spin state of the central metal atom (S = 5/2). The charge-transfer transitions arising from the strong interactions of the phenolate moieties with the ferric ion have been identified as phenolate (p(pi)) --> iron(III) (d(pi*)) (lambda(max) approximately 500 nm, epsilon approximately 3000 M(-1) cm(-1)) and phenolate (p(pi)) --> iron(III) (d(sigma*) (lambda(max) approximately 320 nm, epsilon approximately 5200 M(-1) cm(-1)). The presence of the phenolate moieties in the quadridentate hetero-donor tripodal ligands, H3L, lends these iron(III) ternary complexes the potential to model the specific metal-coordination, metal-substrate interactions, and physicochemical behaviors of several iron-tyrosinate proteins. 相似文献
90.
The reaction of [Cr(NCCH(3))(6)](2+) with dioxygen in acetonitrile (MeCN) solution acidified with HBF(4) gave red crystals of the binuclear complex [(CH(3)CN)(5)Cr(OH)Cr(NCCH(3))(5)](BF(4))(5) (1). From the X-ray crystal structure of 1, the Cr-O-Cr angle was found to be 147.5(2) degrees. Magnetic susceptibility measurements of 1 showed an antiferromagnetic coupling between the two chromium(III) centers with a triplet energy J = 35.9(1) cm(-1). On redissolution of 1 in MeCN, the hydroxo bridge was deprotonated, and a green solution of the complex [(CH(3)CN)(5)CrOCr(NCCH(3))(5)](4+) formed. The electronic absorption spectrum of this solution is very similar to the spectrum of the classical complex [(H(3)N)(5)CrOCr(NH(3))(5)](4+) with intense bands in the UV and near-UV region. From the temperature dependence of the absorption spectrum near 12900 cm(-1), the triplet energy J was found to be 1067(19) cm(-1). The acidity of the hydroxo bridge in 1 is very high with an acid dissociation constant K(a) > 1 M. 相似文献