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81.
Pier Franco Marino Gemma Caterina Maria Rossi Giuseppe Campagna Decio Capobianco Ciro Costagliola 《Molecules (Basel, Switzerland)》2020,25(23)
The aim of the present study was to evaluate the effects of supplementation with a fixed combination of citicoline 500 mg, homotaurine 50 mg, and vitamin E 12 mg (CIT/HOMO/VITE) on contrast sensitivity and visual-related quality of life in patients with primary open-angle glaucoma (POAG) in mild stage. This was a multicenter, observational, cross-over, short-term, pilot study on POAG patients with stable controlled intraocular pressure (IOP). Patients were randomly assigned to Group 1 (current topical therapy for 4 months and then current topical therapy plus CIT/HOMO/VITE for 4 months) or Group 2 (CIT/HOMO/VITE in addition to current topical therapy for 4 months and then topical therapy alone for 4 months). Best-corrected visual acuity, IOP, visual field, and the Spaeth/Richman contrast sensitivity (SPARCS) test score were recorded at baseline and after 4 and 8 months. The Glaucoma Quality of Life-15 (GQL-15) questionnaire was administered at each check time. Forty-four patients were assigned to Group 1 and 65 to Group 2. Over the follow-up period, there were no significant changes in IOP or visual field findings, whereas SPARCS and GQL-15 findings significantly varied from baseline, both being improved in subjects treated with CIT/HOMO/VITE fixed combination. These results demonstrate that a daily intake of a fixed combination of citicoline, homotaurine, and vitamin E in addition to the topical medical treatment significantly increased the total score of the contrast sensitivity test and the quality of life in patients with POAG. 相似文献
82.
Summary
In this paper, using the theory of henselian rings and in particular the notion of henselian and strict henselian couples, we study the behaviour of analytic branches of an affine algebraic variety at a point x, when x varies along a singular subvariety; moreover we construct an algebraic and canonical procedure, which parametrises the branches.
Lavoro eseguito nell'ambito della sez. 3 del G.N.S.A.G.A. del C.N.R. e con il supporto finanziario del Ministero della Pubblica Istruzione. 相似文献
Lavoro eseguito nell'ambito della sez. 3 del G.N.S.A.G.A. del C.N.R. e con il supporto finanziario del Ministero della Pubblica Istruzione. 相似文献
83.
Sandra Gemma Gagan Kukreja Pierangela Tripaldi Maria Altarelli Matteo Bernetti Silvia Franceschini Luisa Savini Giuseppe Campiani Caterina Fattorusso 《Tetrahedron letters》2008,49(13):2074-2077
Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. We described herein the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors. 相似文献
84.
We consider two categories with one object, namely the set of all partial functions of one variable from the set of natural numbers into itself; the morphisms are the partial recursive operators in one case, and certain continuous partial mappings in the other case. We show that these categories are recursion categories and we characterize the domains and the complete domains. Some observations are made on a notion of reducibility obtained by using the total morphisms of these categories, and, subsequently, the general recursive operators. 相似文献
85.
We present two convergence theorems for Hamilton-Jacobi equations and we apply them to the convergence of approximations and perturbations of optimal control problems and of two-players zero-sum differential games. One of our results is, for instance, the following. LetT andT
h be the minimal time functions to reach the origin of two control systemsy = f(y, a) andy = f
h
(y, a), both locally controllable in the origin, and letK be any compact set of points controllable to the origin. If f
h –f Ch, then |T(x) – T
h
(x)| C
K
h
, for all x K, where is the exponent of Hölder continuity ofT(x). 相似文献
86.
The interaction energy between an incoming group X– and the substrate CRH2Y at the geometry of the transition state (TS) for bimolecular nucleophilic substitution reactions (with X, Y, and R equal to H and F) has been subjected to decomposition according to the Morokuma scheme. The influence of the basis set and of the geometry chosen for the TS is examined. The results bring out regular trends in the different terms of the decomposition along the whole set of reactions, but they are not sufficient to give a rationale of the energetic factors involved in these reactions. 相似文献
87.
Caterina Riccardi Shelby McCormick Rajeswari Kasi Challa Kumar 《Angewandte Chemie (International ed. in English)》2018,57(32):10158-10162
A potentially universal approach is presented for enzyme attachment to cellulose that significantly enhances enzyme stability while retaining high activity, and involves no chemical functionalization of cellulose. Bovine serum albumin (BSA) was interlocked in cellulose to form a protein‐friendly surface (named BSA‐Paper), while also providing COOH and NH2 groups for subsequent attachment of enzymes. The desired enzyme is then mixed with additional BSA and interlocked on BSA‐Paper. The second BSA layer dilutes and crosslinks the enzyme for improved stability. Laccase was tested as a model enzyme for interlocking on BSA‐Paper, and was found to retain over 100 % activity and was 240 times more stable at 25 °C (half life=180 d) than laccase. This new approach was also tested with a few other enzymes with encouraging results, thus providing a potentially universal method for stabilization of enzymes on cellulose with retention of high activities. 相似文献
88.
The protonation processes for eight three-membered ring molecules have been investigated using the SCF LCAO MO method with Gaussian basis sets and the results are compared with those obtained at the first order approximation, i.e. the electrostatic approximation. The electrostatic results are linearly connected with the SCF ones and are sufficient to get an ordering of the protonation energies in different chemical sites and to obtain reliable representations of the proton approaching paths. 相似文献
89.
Caterina Minelli Christoph Frommen Christian Hinderling Raphael Pugin Harry Heinzelmann Martha Liley 《Colloid and polymer science》2006,284(5):482-488
Polymer/nanoparticle composite films are receiving growing attention thanks to their potential for application in ultra-thin
electronic and optical devices. Polymer blend demixing has been shown to be a suitable technique for the structuring of polymer
thin films and the patterning of nanoparticles (NP) within them. In this work we show that the morphology of thin polymer
films made by spin-casting a polymer blend solution containing NP fillers on a surface depends strongly on the concentration
of NP fillers. More specifically, polystyrene/polymethylmethacrylate (PS/PMMA) films formed from a toluene solution, and which
demix following a nucleation and growth mechanism, were studied. It was found that both the height and the surface density
of PMMA domains increased as the concentration of CoPt:Cu NPs in the film was increased. We find that similar effects are
induced in a NP-free PS/PMMA demixed film upon increasing the molecular weight of the PS molecules. This suggests that under
certain conditions the NPs and the polymer molecules in the blend do not behave as separate species but form aggregates. 相似文献
90.
Bissantz C Logean A Rognan D 《Journal of chemical information and computer sciences》2004,44(3):1162-1176
The current study describes the development of a computer package (GPCRmod) aimed at the high-throughput modeling of the therapeutically important family of human G-protein coupled receptors (GPCRs). GPCRmod first proposes a reliable alignment of the seven transmembrane domains (7 TMs) of most druggable human GPCRs based on pattern/motif recognition for each of the 7 TMs that are considered independently. It then converts the alignment into knowledge-based three-dimensional (3-D) models starting from a set of 3-D backbone templates and two separate rotamer libraries for side chain positioning. The 7 TMs of 277 human GPCRs have been accurately aligned, unambiguously clustered in three different classes (rhodopsin-like, secretin-like, metabotropic glutamate-like), and converted into high-quality 3-D models at a remarkable throughput (ca. 3s/model). A 3-D GPCR target library of 277 receptors has consequently been setup. Its utility for "in silico" inverse screening purpose has been demonstrated by recovering among top scorers the receptor of a selective GPCR antagonist as well as the receptors of a promiscuous antagonist. The current GPCR target library thus constitutes a 3-D database of choice to address as soon as possible the "virtual selectivity" profile of any GPCR antagonist or inverse agonist in an early hit optimization process. 相似文献