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891.
Adler C Ahammed Z Allgower C Anderson M Averichev GS Balewski J Barannikova O Barnby LS Baudot J Bekele S Belaga VV Bellwied R Berger J Bichsel H Bland LC Blyth CO Bonner BE Bossingham R Boucham A Brandin A Caines H de la Barca Sánchez MC Cardenas A Carroll J Castillo J Castro M Cebra D Chattopadhyay S Chen ML Chen Y Chernenko SP Cherney M Chikanian A Choi B Christie W Coffin JP Conin L Cormier TM Cramer JG Crawford HJ DeMello M Deng WS Derevschikov AA Didenko L Draper JE Dunin VB Dunlop JC 《Physical review letters》2001,86(21):4778-4782
We report results on the ratio of midrapidity antiproton-to-proton yields in Au+Au collisions at sqrt[s(NN)] = 130 GeV per nucleon pair as measured by the STAR experiment at RHIC. Within the rapidity and transverse momentum range of /y/<0.5 and 0.4
相似文献
892.
In recent work with symmetric chaotic systems, we synchronized two such systems with one-way driving. The drive system had two possible attractors, but the response system always synchronized with the drive system. In this work, we show how we may combine two attractor chaotic systems with a multiplexing technique first developed by Tsimring and Suschick to make a simple communications system. We note that our response system is never synchronized to our drive system (not even in a generalized sense), but we are still able to transmit information. We characterize the performance of the communications system when noise is added to the transmitted signal. 相似文献
893.
Jiraborrirak Charoenpattarapreeda Dr. Stephen J. Walsh Prof. Dr. Jason S. Carroll Prof. Dr. David R. Spring 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(51):23245-23250
Hemiasterlin is an antimitotic marine natural product with reported sub-nanomolar potency against several cancer cell lines. Herein, we describe an expeditious total synthesis of hemiasterlin featuring a four-component Ugi reaction (Ugi-4CR) as the key step. The convergent synthetic strategy enabled rapid access to taltobulin (HTI-286), a similarly potent synthetic analogue. This short synthetic sequence enabled investigation of both hemiasterlin and taltobulin as cytotoxic payloads in antibody–drug conjugates (ADCs). These novel ADCs displayed sub-nanomolar cytotoxicity against HER2-expressing cancer cells, while showing no activity against antigen-negative cells. This study demonstrates an improved synthetic route to a highly valuable natural product, facilitating further investigation of hemiasterlin and its analogues as potential payloads in targeted therapeutics. 相似文献
894.
Kar S Markey K Borghesi M Carroll DC McKenna P Neely D Quinn MN Zepf M 《Physical review letters》2011,106(22):225003
By using a thick (250 μm) target with 350 μm radius of curvature, the intense proton beam driven by a petawatt laser is focused at a distance of ~1 mm from the target for all detectable energies up to ~25 MeV. The thickness of the foil facilitates beam focusing as it suppresses the dynamic evolution of the beam divergence caused by peaked electron flux distribution at the target rear side. In addition, reduction in inherent beam divergence due to the target thickness relaxes the curvature requirement for short-range focusing. Energy resolved mapping of the proton beam trajectories from mesh radiographs infers the focusing and the data agree with a simple geometrical modeling based on ballistic beam propagation. 相似文献
895.
McKenna P Robinson AP Neely D Desjarlais MP Carroll DC Quinn MN Yuan XH Brenner CM Burza M Coury M Gallegos P Gray RJ Lancaster KL Li YT Lin XX Tresca O Wahlström CG 《Physical review letters》2011,106(18):185004
The effect of lattice structure on the transport of energetic (MeV) electrons in solids irradiated by ultraintense laser pulses is investigated using various allotropes of carbon. We observe smooth electron transport in diamond, whereas beam filamentation is observed with less ordered forms of carbon. The highly ordered lattice structure of diamond is shown to result in a transient state of warm dense carbon with metalliclike conductivity, at temperatures of the order of 1-100?eV, leading to suppression of electron beam filamentation. 相似文献
896.
A series of conformationally flexible bicyclic N-arylimides were employed as molecular balances to study the weak aliphatic CH-π interaction between alkyl and arene groups. The formation of intramolecular CH-π interactions in the folded conformers was characterized by X-ray crystallography. The strengths of the interactions were characterized in CDCl(3) by the changes in the folded/unfolded ratios, as measured by (1)H NMR. The CH-π interaction between a methyl group and an aromatic surface was ~1.0 kcal/mol and was easily disrupted or masked by conformational entropy and repulsive steric interactions. 相似文献
897.
898.
Lewis RA Nunns L Thirlway J Carroll K Smith CP Micklefield J 《Chemical communications (Cambridge, England)》2011,47(6):1860-1862
Using site directed mutagenesis we altered an active site residue (Phe107) of the enzyme encoded by fabF3 (SCO3248) in the Streptomyces coelicolor gene cluster required for biosynthesis of the calcium dependent antibiotics (CDAs), successfully generating two novel CDA derivatives comprising truncated (C4) lipid side chains and confirming that fabF3 encodes a KAS-II homologue that is involved in determining CDA fatty acid chain length. 相似文献
899.
Ye S Routzahn AL Carroll RL 《Langmuir : the ACS journal of surfaces and colloids》2011,27(22):13806-13812
Sphere lithography (SL), sometimes erroneously generalized as nanosphere lithography (NSL), stands out as a versatile technique capable of producing 2D periodic micro- and nanostructures with general materials applicability, flexible size and shape control, high throughput, and elegance of simplicity. Many of the fundamental aspects of the features produced by SL have been investigated in a systematic manner, including the optical, magnetic, electronic, and catalytic behaviors with emphasis toward applications in biosensing, ultrasensitive spectroscopy, and nanodevice fabrication. Previous work has primarily focused on two-dimensional patterning, however, with little attention paid to vertical growth of the SL features. In this work, the 3D structural evolution of metal dot arrays at two different length scales was demonstrated by SL-based geometrically structured dynamic shadowing lithography (GSDSL). An empirically derived model of structural growth is also developed to predict the shape and size of the features in this system. 相似文献
900.
Kodali VK Scrimgeour J Kim S Hankinson JH Carroll KM de Heer WA Berger C Curtis JE 《Langmuir : the ACS journal of surfaces and colloids》2011,27(3):863-865
Graphene's extraordinary physical properties and its planar geometry make it an ideal candidate for a wide array of applications, many of which require controlled chemical modification and the spatial organization of molecules on its surface. In particular, the ability to functionalize and micropattern graphene with proteins is relevant to bioscience applications such as biomolecular sensors, single-cell sensors, and tissue engineering. We report a general strategy for the noncovalent chemical modification of epitaxial graphene for protein immobilization and micropatterning. We show that bifunctional molecule pyrenebutanoic acid-succinimidyl ester (PYR-NHS), composed of the hydrophobic pyrene and the reactive succinimide ester group, binds to graphene noncovalently but irreversibly. We investigate whether the chemical treatment perturbs the electronic band structure of graphene using X-ray photoemission (XPS) and Raman spectroscopy. Our results show that the sp(2) hybridization remains intact and that the π band maintains its characteristic Lorentzian shape in the Raman spectra. The modified graphene surfaces, which bind specifically to amines in proteins, are micropatterned with arrays of fluorescently labeled proteins that are relevant to glucose sensors (glucose oxidase) and cell sensor and tissue engineering applications (laminin). 相似文献