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71.
Dr. Andreas A. Bastian Dr. Maria Bastian Dr. Manuel Jäger Mark Loznik Dr. Eliza M. Warszawik Xintong Yang Dr. Nabil Tahiri Dr. Peter Fodran Prof. Dr. Martin D. Witte Anne Thoma Dr. Jens Köhler Prof. Dr. Adriaan J. Minnaard Prof. Dr. Andreas Herrmann 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(36):e202200883
The continuous emergence of antimicrobial resistance is causing a threat to patients infected by multidrug-resistant pathogens. In particular, the clinical use of aminoglycoside antibiotics, broad-spectrum antibacterials of last resort, is limited due to rising bacterial resistance. One of the major resistance mechanisms in Gram-positive and Gram-negative bacteria is phosphorylation of these amino sugars at the 3’-position by O-phosphotransferases [APH(3’)s]. Structural alteration of these antibiotics at the 3’-position would be an obvious strategy to tackle this resistance mechanism. However, the access to such derivatives requires cumbersome multi-step synthesis, which is not appealing for pharma industry in this low-return-on-investment market. To overcome this obstacle and combat bacterial resistance mediated by APH(3’)s, we introduce a novel regioselective modification of aminoglycosides in the 3’-position via palladium-catalyzed oxidation. To underline the effectiveness of our method for structural modification of aminoglycosides, we have developed two novel antibiotic candidates overcoming APH(3’)s-mediated resistance employing only four synthetic steps. 相似文献
72.
利用改进的Sonogashira反应一锅法合成了一例未见报道的叁键桥联的联吡啶类化合物L[2,6-二(3'-吡啶乙炔基)-4-甲基苯胺],与常规的分步合成方法相比,新方法不需脱除保护,从而简化了反应步骤,提高了产率.对所合成的化合物利用红外、核磁、元素分析等确定了其结构,并进一步利用X射线单晶衍射法测得了该化合物的单晶结构.单晶分析显示该化合物结晶于正交晶系、Pca21空间群中,a=10.178A,b=10.972A,c=28.949 A;a=β=γ=90°,Z=8.该化合物在配位化学方面具有潜在的应用前景.我们测定了其固态下的荧光性质,显示其能够发出较强的蓝色光. 相似文献
73.
74.
Several transition metal salts, as solids, were exposed to gaseous ammonia at room temperature in a cell designed to allow measurement of infrared energy absorption at various pressures. For those salts which did form compounds with the ammonia, the new absorption bands are discussed in reference to spectra of amine complexes of known composition. 相似文献
75.
Hou Chen Chunhua Wang Delong Liu Yuting Song Rongjun Qu Changmei Sun Chunnuan Ji 《Journal of polymer science. Part A, Polymer chemistry》2010,48(1):128-133
Atom transfer radical polymerization using activators generated by electron transfer (AGET ATRP) of acrylonitrile (AN) initiated by ethyl 2‐bromoisobutyrate was approached for the first time using 1,1,4,7,10,10‐hexamethyltriethylenetetramine (HMTETA) and 1,1,4,7,7‐pentamethyldiethylenetriamine (PMDETA) as both ligand and reducing agent. AGET ATRP of AN with HMTETA as both ligand and reducing agent was better controlled than with PMDETA as both ligand and reducing agent under the same experimental conditions. With an increase content of HMTETA, the polymerization provided an accelerated reaction rate and a broader polymer molecular weight distribution. The rate of polymerization with DMF as solvent was faster than with acetonitrile, cyclohexanone, toluene, and xylene as solvents. The polymerization apparent activation energy was calculated to be 45.7 kJ mol?1. The end functionality of polyacrylonitrile (PAN) was confirmed by 1H NMR spectroscopy. The living feature of PAN was verified by chain extensions of PAN with methyl methacrylate and AN. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 128–133, 2010 相似文献
76.
With 〈·〉 denoting an average with respect to the eigenvalue PDF for the Laguerre unitary ensemble, the object of our study is for I = (0, s) and I = (s, ∞), where χ = 1 for λl ∈ I and χ = 0 otherwise. Using Okamoto's development of the theory of the Painlevé V equation, it is shown that ?N(I; a, μ) is a τ‐function associated with the Hamiltonian therein, and so can be characterized as the solution of a certain second‐order second‐degree differential equation, or in terms of the solution of certain difference equations. The cases μ = 0 and μ = 2 are of particular interest, because they correspond to the cumulative distribution and density function, respectively, for the smallest and largest eigenvalue. In the case I = (s, ∞), ?N(I; a, μ) is simply related to an average in the Jacobi unitary ensemble, and this in turn is simply related to certain averages over the orthogonal group, the unitary symplectic group, and the circular unitary ensemble. The latter integrals are of interest for their combinatorial content. Also considered are the hard‐edge and soft‐edge scaled limits of ?N(I; a, μ). In particular, in the hard‐edge scaled limit it is shown that the limiting quantity ?hard((O, s); a, μ) can be evaluated as a τ‐function associated with the Hamiltonian in Okamoto's theory of the Painlevé III equation. © 2002 Wiley Periodicals, Inc. 相似文献
77.
A.T. Winzer R. Goldhahn G. Gobsch A. Dadgar H. Witte A. Krtschil A. Krost 《Superlattices and Microstructures》2004,36(4-6):693
Photoreflectance spectroscopy was used to measure the barrier electric field strength F of as-grown AlGaN/GaN heterostructures on Si(111) substrate with two-dimensional electron gases in the temperature range from 80 up to 295 K. The Al-contents were in the range from 12 to 20%. Despite the difference of Al-contents and the large temperature variation we find only minute changes of F. This behaviour is explained by an almost constant strain state and thus a constant piezoelectric polarisation, which was concluded from the analysis of the GaN free excitonic transitions observed by photoluminescence excitation spectroscopy. Self-consistent conduction band calculations point to a pinning of the potential of the bare surface at 0.6 V, attributed to a large density of surface donor states. 相似文献
78.
Delong Zhang Xiaojun ChenYufang Wang Dengsong ZhuBo Wu Guoxiang Lan 《Journal of Physics and Chemistry of Solids》2002,63(2):345-358
Raman spectra of as-grown and vapor transport equilibration (VTE) treated Er:LiNbO3 crystals, which have different cut orientations (X-cut and Z-cut), different Er-doping levels (Er:(0.2, 0.4 and 2.0 mol%)LiNbO3) and different VTE durations (80, 120, 150 and 180 h), were recorded at room temperature in the wavenumber range 50-1000 cm−1 by using backward scattering geometry. The spectra were attributed on the basis of their spectral features and the previous experimental work and the most recent theoretical progress in lattice dynamics on pure LiNbO3. In comparison with the pure crystal the most remarkable effect of Er-doping on the Raman spectrum is observed for the E(TO9) mode. It does not appear at 610 cm−1 as the pure crystal, but locates at 633 cm−1. In addition, the doping also results in the lowering of the Raman phonon frequency, the broadening of the Raman linewidth and the changes of the relative Raman intensity of some peaks. The VTE treatment results in the narrowing of the linewidth, the recovery of the lowered phonon frequency and the further changes of relative Raman intensity. The narrowing of Raman linewidth indicates that the VTE processing has brought these crystals closer to stoichiometric composition. The VTE treatment has induced the formation of a precipitate ErNbO4 in the high-doped Er(2.0%):LiNbO3 crystals whether X- or Z-cut. For these precipitated crystals, besides above linewidth and phonon frequency features, they also display more significant Raman intensity changes compared with those not precipitated crystals. In addition, a slight mixing between A1(TO) and E(TO) spectra is also observed for these precipitated crystals. Above doping and VTE effects on Raman spectra were quantitatively or qualitatively correlated with the characteristics of the crystal structure and phonon vibrational system. 相似文献
79.
David A. Hall Donnis M. Berry Carol J. Schneider 《Journal of Electroanalytical Chemistry》1977,80(1):155-170
The electrochemical behavior of cephalothin has been studied by a.c. and d.c. polarography, cyclic voltammetry, and coulometry in both aqueous and nonaqueous media in order to gain a greater understanding of the reaction pathways involved in cephalosporin reduction. The reductive allylic cleavage of the 3′-acetoxy function has been found to produce Δ3-deacetoxy and 3-exomethylene cephalothin compounds (geometric isomers) and stereochemical isomers of the 3′-exomethylene compound at the 4-position. The ratio of these compounds to one another is dependent on the experimental conditions used, with adsorption playing an important role. The reductive allylic cleavage of the S1?C2 bond is a competitive reaction pathway. Δ3-Deacetoxy cephalothin may undergo further reduction, depending on the electrolysis potential selected. 相似文献
80.