全文获取类型
收费全文 | 310篇 |
免费 | 2篇 |
国内免费 | 1篇 |
专业分类
化学 | 164篇 |
晶体学 | 1篇 |
力学 | 4篇 |
数学 | 21篇 |
物理学 | 123篇 |
出版年
2022年 | 2篇 |
2020年 | 2篇 |
2019年 | 2篇 |
2016年 | 2篇 |
2015年 | 2篇 |
2014年 | 5篇 |
2013年 | 15篇 |
2012年 | 2篇 |
2011年 | 7篇 |
2010年 | 4篇 |
2009年 | 10篇 |
2008年 | 18篇 |
2007年 | 10篇 |
2006年 | 9篇 |
2005年 | 8篇 |
2004年 | 11篇 |
2003年 | 7篇 |
2002年 | 5篇 |
2001年 | 8篇 |
2000年 | 7篇 |
1999年 | 8篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 10篇 |
1995年 | 18篇 |
1994年 | 8篇 |
1993年 | 11篇 |
1992年 | 7篇 |
1991年 | 7篇 |
1990年 | 7篇 |
1989年 | 2篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 11篇 |
1985年 | 8篇 |
1984年 | 2篇 |
1983年 | 4篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 8篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1976年 | 5篇 |
1975年 | 3篇 |
1972年 | 2篇 |
1968年 | 2篇 |
1939年 | 3篇 |
1936年 | 2篇 |
1935年 | 2篇 |
1896年 | 1篇 |
排序方式: 共有313条查询结果,搜索用时 78 毫秒
51.
52.
The solution and solid state conformation of (S)-4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk][1,4]-benzodiazepin-2(1H)-one (R78362) have been investigated by low temperature NMR and x-ray diffraction studies. The 1H NMR spectrum of R78362 shows no evidence of the presence of multiple conformers in the temperature range 340K - 177K. Molecular mechanisms and semiempirical molecular orbital calculations suggest that the nitrogen and ring inversion barriers of R78362 are small and thus a time-averaged 1H NMR spectrum is probably occurring at 298K. The x-ray diffraction data indicated that there were two independent molecules in the asymmetric unit of the crystal. The two molecules had similar conformations with the benzoimidazole ring being planar and the diazepine ring in a “half-chair” conformation. 相似文献
53.
An efficient method for calculating the Lagrange multipliers and the analytical gradients of one state included in a state average MCSCF wave function is presented. It is demonstrated that the state average energy of an ‘equal-weight’ scheme is invariant to rotations within the state average subspace and that the corresponding rotations should be eliminated from the Lagrangian equations. Finally, a diagnostic is presented, which gauges the energy difference between a state defined by a state average calculation and the corresponding fully variational multi-configurational SCF state. 相似文献
54.
Jordan BJ Pollier MA Ofir Y Joubanian S Mehtala JG Sinkel C Caldwell ST Kennedy A Rabani G Cooke G Rotello VM 《Chemical communications (Cambridge, England)》2008,(14):1653-1655
We report the modulation of the absorbance of a flavin push-pull derivative through specific recognition by a complementary diamidopyridine (DAP), shifting the flavin intramolecular charge transfer band by approximately 30 nm. 相似文献
55.
Caldwell ST Cooke G Cooper A Nutley M Rabani G Rotello V Smith BO Woisel P 《Chemical communications (Cambridge, England)》2008,(23):2650-2652
A biotinylated 1,5-dialkoxynaphthalene derivative has been shown to have the ability to bind strongly to avidin and thus act as an artificial binding site for cyclobis(paraquat-p-phenylene) thereby facilitating the formation of a tuneable pseudorotaxane-based bioconjugate. 相似文献
56.
Caldwell LM Hill AF Wagler J Willis AC 《Dalton transactions (Cambridge, England : 2003)》2008,(27):3538-3541
The first examples of isoselenocarbonyl linked bimetallics arise from the chemoselective insertion of platinum(0) into the alkynyl-selenium bond of a molybdenum alkynylselenolatoalkyidyne complex. 相似文献
57.
58.
Bhatti BS Strachan JP Breining SR Miller CH Tahiri P Crooks PA Deo N Day CS Caldwell WS 《The Journal of organic chemistry》2008,73(9):3497-3507
In an attempt to generate nicotinic acetylcholine receptor (nAChR) ligands selective for the alpha4beta2 and alpha7 subtype receptors we designed and synthesized constrained versions of anabasine, a naturally occurring nAChR ligand. 2-(Pyridin-3-yl)-1-azabicyclo[2.2.2]octane, 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, and several of their derivatives have been synthesized in both an enantioselective and a racemic manner utilizing the same basic synthetic approach. For the racemic synthesis, alkylation of N-(diphenylmethylene)-1-(pyridin-3-yl)methanamine with the appropriate bromoalkyltetrahydropyran gave intermediates which were readily elaborated into 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane and 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane via a ring opening/aminocyclization sequence. An alternate synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane via the alkylation of N-(1-(pyridin-3-ylethylidene)propan-2-amine has also been achieved. The enantioselective syntheses followed the same general scheme, but utilized imines derived from (+)- and (-)-2-hydroxy-3-pinanone. Chiral HPLC shows that the desired compounds were synthesized in >99.5% ee. X-ray crystallography was subsequently used to unambiguously characterize these stereochemically pure nAChR ligands. All compounds synthesized exhibited high affinity for the alpha4beta2 nAChR subtype ( K i < or = 0.5-15 nM), a subset bound with high affinity for the alpha7 receptor subtype ( K i < or = 110 nM), selectivity over the alpha3beta4 (ganglion) receptor subtype was seen within the 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane series and for the muscle (alpha1betagammadelta) subtype in the 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane series. 相似文献
59.
Yan Z Maher N Torres R Cotto C Hastings B Dasgupta M Hyman R Huebert N Caldwell GW 《Rapid communications in mass spectrometry : RCM》2008,22(13):2021-2028
In addition to matrix effects, common interferences observed in liquid chromatography/tandem mass spectrometry (LC/MS/MS) analyses can be caused by the response of drug-related metabolites to the multiple reaction monitoring (MRM) channel of a given drug, as a result of in-source reactions or decomposition of either phase I or II metabolites. However, it has been largely ignored that, for some drugs, metabolism can lead to the formation of isobaric or isomeric metabolites that exhibit the same MRM transitions as parent drugs. The present study describes two examples demonstrating that interference caused by isobaric or isomeric metabolites is a practical issue in analyzing biological samples by LC/MS/MS. In the first case, two sequential metabolic reactions, demethylation followed by oxidation of a primary alcohol moiety to a carboxylic acid, produced an isobaric metabolite that exhibits a MRM transition identical to the parent drug. Because the drug compound was rapidly metabolized in rats and completely disappeared in plasma samples, the isobaric metabolite appeared as a single peak in the total ion current (TIC) trace and could easily be quantified as the drug since it was eluted at a retention time very close to that of the drug in a 12-min LC run. In the second example, metabolism via the ring-opening of a substituted isoxazole moiety led to the formation of an isomeric product that showed an almost identical collision-induced dissociation (CID) MS spectrum as the original drug. Because two components were co-eluted, the isomeric product could be mistakenly quantified and reported by data processing software as the parent drug if the TIC trace was not carefully inspected. Nowadays, all LC/MS data are processed by computer software in a highly automated fashion, and some analysts may spend much less time to visually examine raw TIC traces than they used to do. Two examples described in this article remind us that quality data require both adequate chromatographic separations and close examination of raw data in LC/MS/MS analyses of drugs in biological matrix. 相似文献
60.
Feiler AA Sahlholm A Sandberg T Caldwell KD 《Journal of colloid and interface science》2007,315(2):475-481
The adsorption profile and viscoelastic properties of bovine submaxillary gland mucin (BSM) and bovine serum albumin (BSA), extracted from a commercial mucin preparation, adsorbing to polystyrene surfaces has been studied using quartz crystal microbalance with dissipation monitoring (QCM-D). A significant difference in the adsorption properties of the different proteins was detected; with the BSA adsorbing in a flat rigid layer whilst the mucin adsorbed in a diffuse, highly viscoelastic layer. Subsequent addition of BSA to the preadsorbed mucin layer resulted in stiffening of the protein layer which was attributed to complexation of the mucin by BSA. In contrast, a preadsorbed layer of BSA prevented mucin adsorption altogether. Combined mixtures of mucin and BSA in well defined ratios revealed intermediate properties between the two separate protein species which varied systematically with the protein ratios. The results shed light on the synergistic effects of complexation of lower molecular weight biomolecular species with mucin. The possibility to selectively control protein uptake and tailor the physical properties of the adsorbed layer makes mucin an attractive option for application in biomaterial coatings. 相似文献