The fabrication and characterization of poly(lactic acid) scaffolds for tissue engineering by improved solid–liquid phase separation

In this article a new technique was developed to fabricate scaffolds with a unique microstructure by solid–liquid separation in combination with particulate-leaching. Firstly, the effects of polymer concentration, quenching temperature on the porous morphology and the mechanical property of obtained scaffolds during solid–liquid separation have been investigated. Then, salt granules as porogen were introduced into the solid–liquid phase separation to produce the unique pore structure of the scaffold. The pore diameter of the scaffold could be controlled with the particulate size and the wall of pores possessed special microstructure, which enhanced the pore interconnectivity. The cell culture results confirmed that a good interconnectivity of the scaffold prepared by the improved solid–liquid separation was useful for nutrition transportation and cell proliferation. Copyright © 2003 John Wiley & Sons, Ltd.     

硫化物/Ru(Ⅱ)结合物复合敏化TiO_2纳米多孔膜

用光电化学方法研究了Cds、Pbs和RuL2（NCS）2（L＝2.2′-bipydine-4.4′-dicarboxylicacid）复合敏化TiO2。纳米晶电极的光电化学行为．结果表明，采用复合敏化比用rul（Ⅱ）络合物单独敏化TiO2。纳米晶电极效果好，大大提高了光电转换效率．主要原因是采用复合敏化，可防止TiO2导带上由光注入产生的电子的反向转移，避免了电子的损失．     

神经系统铅中毒

阐述了铅对人类尤其是胎儿、婴幼儿神经系统毒害的病因、发病机制、临床表现及治疗，并提出解决铅中毒的关键是易感人群的预防。     

肾病综合症、过敏性紫癜患儿血清原中铅含量研究

采用原子吸收光谱法，测定了肾病综合症、过敏性紫癜患儿血清和尿中铅含量，均高于近期国内外报道允许正常值，给临床治疗和诊断提供了一个新的研究途径。     

微量元素制剂辅助治疗复发性口疮疗效观察

报道了１０３例ＲＡＵ患者使用微量元素制剂辅助治疗的临床疗效观察。将两个实验组分别与对照组比较。结果显示：应用锌、铁制剂辅助雷公藤、复方丹参等治疗的实验组Ｉ效果优于雷公藤、复方丹参对照组（Ｐ〈０．０１），而仅用锌、铁制剂治疗的实验组Ⅱ临床效果比对照组差（Ｐ〈０．０１），但锌、铁制剂有改善ＲＡＵ临床症状作用，而不能较好地控制其复发。     

含氰基侧基聚芳醚砜的合成与表征

汉２，６－二卤苯甲腈、４，４′－二氯二苯砜、４，４′－二羟基二苯砜、间苯二酚、对苯二酚、酚酞及双酚Ａ为主要原料，合成了含不同结构单元和不同氰基含量的含氰基侧基的聚芳醚砜，并采用ＩＲ、＾１３ＣＮＭＲ等分析手段对其结构进行了表征，同时研究了结构单元和氰基含量对聚芳醚砜性能的影响。     

病毒性心肌炎与微量元素关系的探讨

应用日本岛津ＩＣＰＱ－１０１２型高频等离子体发射光谱仪测定了病毒性心肌炎组４７例和正常儿童组６０例全血中１４种元素的水平，结果表明，心肌炎组血锌、铁、铜、钴、钛、铬、镍、铅、钛、镉的含量低于正常组，两者间有显著和非常显著性差异（Ｐ〈０．０５，Ｐ〈０．０１），血钼、锶则高于正常组，且有显著性差异（Ｐ〈０．０５），血锰、镁、钙与正常组无差异（Ｐ〉０．０５），提示病毒性心肌炎的患儿存在着血锌、铁、铜、钴     

动力学分析法研究生物反应活性中间体及其相关反应

评述了动力学分析法研究生物反应活性中间体的意义，存在的困难，研究方法及近年来 一多学科交叉与渗透领域的研究进展。     

Synthesis of comb‐shaped poly(methyl methacrylate)‐b‐poly(polytetrahydrofuran acrylate) under 60Co γ‐ray irradiation

Comb‐shaped graft copolymers with poly(methyl methacrylate) as a handle were synthesized by the macromonomer technique in two steps. First, polytetrahydrofuran acrylate (A‐PTHF), prepared by the living cationic ring‐opening polymerization of tetrahydrofuran, underwent homopolymerization with 1‐(ethoxycarbonyl)prop‐1‐yl dithiobenzoate as an initiator under ⁶⁰Co γ irradiation at room temperature; Second, the handle of the comb‐shaped copolymers was prepared by the block copolymerization of methyl methacrylate with P(A‐PTHF) as a macroinitiator under ⁶⁰Co γ irradiation. The two‐step polymerizations were proved to be controlled with the following evidence: the straight line of ln[M]₀/[M] versus the polymerization time, the linear increase in the number‐average molecular weight with the conversion, and the relatively narrow molecular weight distribution. The structures of the P(A‐PTHF) and final comb‐shaped copolymers were characterized by ¹H NMR spectroscopy and gel permeation chromatography. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 3367–3378, 2002     

Dinickel Complexes Bridged by Unusual (N,O,O′)-Coordinated α-Amino Acids: Syntheses,Structural Characterization and Magnetic Properties

Four novel dinickel complexes, coordinated by mixed ligands of tren and racemic amino acids, namely [Ni₂(tren)₂(dl-alaninato)(H₂O)]I₃·2H₂O (1), [Ni₂(tren)₂(dl-leucinato)(H₂O)]I₃·2.5H₂O (2), [Ni₂(tren)₂(dl-phenylalaninato)(H₂O)]I₃·H₂O (3), and {[Ni₂(tren)₂(dl-histinato)](ClO₄)₃·1.5H₂O} _n (4), have been synthesized and structurally characterized by X-ray crystallography, FTIR, u.v. and e.s. spectra. They represent the first series of dinickel(II) complexes bridged by the unusual (N,O,O)-coordinated -amino acids. In complexes (1–3), one of the nickel(II) centers is coordinated by four N-atoms of the tren ligand, one O-atom of the carboxylate group of the amino acidato ligand and one H₂O molecule. The other nickel(II) center is also coordinated by the four N-atoms of the tren ligand, one carboxylic O-atom and the amino N-atom of the amino acidato ligand, resulting in an asymmetric dinuclear core with chromophores of NiN₄O₂ and NiN₅O. In the polymeric {[Ni₂(tren)₂(dl-histinato)](ClO₄)₃·1.5H₂O} _n (4), the imidazole N-atom is also involved in ligation with nickel(II) and both nickel(II) centers have the same chromophore described as NiN₅O. The Ni...Ni distances are in the 5.5199(10)–5.5807(15)Å range. Analyses of the magnetic properties of complexes (1), (3) and (4) show that a weak ferromagnetic interaction exists between the two nickel(II) centers.