Synthesis and antiviral activity of new benzothiadiazine dioxide derivatives

A series of 2,1,3‐ and 1,2,4‐benzothiadiazine derivatives were synthesized by alkylation via Mitsunobu reaction and evaluated for their antiviral activity against ADV, HHV‐6, Cox‐B5 and H‐CMV. Most of them were active at micromolar level against one or more viral strains. All the molecules studied are poorly cytotoxic (maximum non toxic concentrations were >25μM), except one compound that presents a higher cytotoxicity (maximum non toxic concentration was 6 μM).     

Probenecid and benzamide: cocrystal prepared by a green method and its physico-chemical and pharmaceutical characterization

Journal of Thermal Analysis and Calorimetry - The eco-friendly method of kneading was here used to synthesize a cocrystal of probenecid, an uricosuric drug used in treating gout and hyperuricemia,...     

Remarks on Singularities, Dimension and Energy Dissipation for Ideal Hydrodynamics and MHD

For weak solutions of the incompressible Euler equations, there is energy conservation if the velocity is in the Besov space B ³ _s with s greater than 1/3. B ³ _s consists of functions that are Lip(s) (i.e., H?lder continuous with exponent s) measured in the L ^p norm. Here this result is applied to a velocity field that is Lip(α₀) except on a set of co-dimension on which it is Lip($agr;₁), with uniformity that will be made precise below. We show that the Frisch-Parisi multifractal formalism is valid (at least in one direction) for such a function, and that there is energy conservation if . Analogous conservation results are derived for the equations of incompressible ideal MHD (i.e., zero viscosity and resistivity) for both energy and helicity . In addition, a necessary condition is derived for singularity development in ideal MHD generalizing the Beale-Kato-Majda condition for ideal hydrodynamics. Received: 21 March 1995 / Accepted: 6 August 1996     

Physico-chemical study of norfloxacin and metronidazole binary mixtures

Journal of Thermal Analysis and Calorimetry - The physico-chemical characterization of norfloxacin commercial sample (NF), norfloxacin anhydrous form A (NFanhA), norfloxacin pentahydrate...     

Physico-chemical and pharmaceutical characterization of sulindac–proglumide binary system

Journal of Thermal Analysis and Calorimetry - Sulindac is a nonsteroidal anti-inflammatory drug with poor water solubility. This study presents a way to increase its dissolution rate while reducing...     

Non-Local Scattering Kernel and the Hydrodynamic Limit

In this paper we study the interaction of a fluid with a wall in the framework of the kinetic theory. We consider the possibility that the fluid molecules can penetrate the wall to be reflected by the inner layers of the wall. This results in a scattering kernel which is a non-local generalization of the classical Maxwell scattering kernel. The proposed scattering kernel satisfies a global mass conservation law and a generalized reciprocity relation. We study the hydrodynamic limit performing a Knudsen layer analysis, and derive a new class of (weakly) nonlocal boundary conditions to be imposed to the Navier–Stokes equations.     

Peculiar acceleration

It has been proposed recently to observe the change in cosmological redshift of distant galaxies or quasars with the next generation of large telescope and ultra-stable spectrographs (the so-called Sandage–Loeb test). Here we investigate the possibility of observing the change in peculiar velocity in nearby clusters and galaxies. This “peculiar acceleration” could help reconstructing the gravitational potential without assuming virialization. We show that the expected effect is of the same order of magnitude of the cosmological velocity shift. Finally, we discuss how to convert the theoretical predictions into quantities directly related to observations.     

Piecewise-linear programming: The compact (CPLP) algorithm

A compact algorithm is presented for solving the convex piecewise-linear-programming problem, formulated by means of a separable convex piecewise-linear objective function (to be minimized) and a set of linear constraints. This algorithm consists of a finite sequence of cycles, derived from the simplex method, characteritic of linear programming, and the line search, characteristic of nonlinear programming. Both the required storage and amount of calculation are reduced with respect to the usual approach, based on a linear-programming formulation with an expanded tableau. The tableau dimensions arem×(n+1), wherem is the number of constraints andn the number of the (original) structural variables, and they do not increase with the number of breakpoints of the piecewise-linear terms constituting the objective function.