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21.
Abstract Due to the wide use of polymers in medicine, researchers are required to solve a very important problem–to understand the interaction between materials of nonphysiological origin and the surrounding biological liquids, and tissues, particularly blood. 相似文献
22.
Maria Elaine Araruna Pablo Silva Maria Almeida Renaly Rêgo Raiff Dantas Hilton Albuquerque Ingrid Cabral Nadjaele Apolinrio Francinalva Medeiros Ana Medeiros Vanda Santos 《Molecules (Basel, Switzerland)》2021,26(6)
Spondias mombin L. (Anacardiaceae) has a worldwide distribution and is present in all regions of Brazil. Its leaves, flowers and bark are used as teas in folk medicine to treat diseases of the digestive system. This study aimed to evaluate the acute non-clinical toxicity, gastroprotective activity, and the related mechanisms of action of nebulized extract and tablets based on dried Spondias mombin (SmNE). SmNE screening showed the presence of flavonoids (0.65%), polyphenols (25.50%), where the major compound is gallic acid. In the acute oral toxicity assay, a dose of 2000 mg/kg of SmNE administered orally in Swiss mice did not induce any behavioral changes. SmNE (250 or 500 mg/kg p.o) significantly reduced the ulcerative lesion area when compared to the control group in ethanol and non-steroidal anti-inflammatory drug (NSAIDs) models. Results showed that treatment with SmNE (250 mg/kg) reduced acid secretion and gastric content, accompanied with an increase in pH. Previous administration of indomethacin and glibenclamide reversed the protection provided by SmNE, confirming the participation of prostaglandins (PGs) and ATP-sensitive potassium channels (KATP) in its gastroprotective effect. The SmNE tablets met the pharmacopeial quality requirements with gastroprotective activity and similar protection in comparison to the isolated extract administrated. In conclusion, SmNe has a gastroprotective activity related to cytoprotective mechanisms, such as the participation of endogenous prostaglandins and KATP channels, having an anti-secretory effect with systemic action. The formulation obtained presented gastroprotective effects similar to the administration of the extract, the tablets showed favorable compression characteristics by the direct route and met the pharmacopeial quality requirements. 相似文献
23.
Giovanna Oliveira de Brito Bruna Cabral Reis Eduardo A. Ferreira Nilton T. Vilela Junqueira Lívia C. L. S-Barreto Fulvio Mattivi Urska Vrhovsek Eliana Fortes Gris 《Molecules (Basel, Switzerland)》2022,27(8)
Taperebá (Spondias mombin L.) is a native species of the Brazilian Cerrado that has shown important characteristics such as a significant phenolic compound content and biological activities. The present study aimed to characterize the phenolic compound profile and antioxidant activity in taperebá peel extract, as well as microencapsulating the extract with chitosan and evaluating the stability of the microparticles. The evaluation of the profile of phenolic compounds was carried out by UPLC-MS/MS. The in vitro antioxidant activity was evaluated by DPPH and ABTS methods. The microparticles were obtained by spray drying and were submitted to a stability study under different temperatures. In general, the results showed a significant content of polyphenols and antioxidant activity. The results of UPLC-MS/MS demonstrated a significant content of polyphenols in taperebá peel, highlighting the high content of ellagic acid and quercetin compounds. There was significant retention of phenolic compounds when microencapsulated, demonstrating high retention at all evaluated temperatures. This study is the first to microencapsulate the extract of taperebá peel, in addition to identifying and quantifying some compounds in this fruit. 相似文献
24.
25.
Paola D. D. S. Maia Diego dos Santos Baio Hayandra F. Nanini Victor Paulo F. da Silva Lissa Bantim Frambach Iuri Matheus Cabral Beatriz Pêgo Beatriz E. Ribeiro Mauro Srgio Gonalves Pavo Vania M. F. Paschoalin Heitor S. P. de Souza Anna Paola T. R. Pierucci 《Molecules (Basel, Switzerland)》2022,27(4)
Phenolic compounds (PCs) present in foods are associated with a decreased risk of developing inflammatory diseases. The aim of this study was to extract and characterize PCs from craft beer powder and evaluate their potential benefits in an experimental model of inflammatory bowel disease (IBD). PCs were extracted and quantified from pure beer samples. BALB/c mice received either the beer phenolic extract (BPE) or beer powder fortified with phenolic extract (BPFPE) of PCs daily for 20 days by gavage. Colon samples were collected for histopathological and immunohistochemical analyses. Dextran sodium sulfate (DSS)-induced mice lost more weight, had reduced colon length, and developed more inflammatory changes compared with DSS-induced mice treated with either BPE or BPFPE. In addition, in DSS-induced mice, the densities of CD4- and CD11b-positive cells, apoptotic rates, and activation of NF-κB and p-ERK1/2 MAPK intracellular signaling pathways were higher in those treated with BPE and BPFPE than in those not treated. Pretreatment with the phenolic extract and BPFPE remarkably attenuated DSS-induced colitis. The protective effect of PCs supports further investigation and development of therapies for human IBD. 相似文献
26.
J. M. Rivas Mercury A. A. Cabral A. E. M. Paiva R. S. Angélica R. F. Neves T. Scheller 《Journal of Thermal Analysis and Calorimetry》2011,104(2):635-643
This article studied the thermal behavior and the evolution of the crystalline phases with temperature of the red mud (bauxite tailing) from an aluminum industry at Maranhão, North-Northwestern Brazil. The experiments were carried out by Field Emission Scanning Electron Microscopy (FE-SEM), Simultaneous Thermal Analysis (TG–DSC), Optical Dilatometry up to 1623 K, and X-ray diffraction (XRD) of previously heated samples between 523 and 1523 K. The crystalline phases and the amorphous contents were quantified on raw and heated samples (at 1523 K) according to the Rietveld Quantitative Analysis (RQA) method. The data obtained showed that the raw red mud is composed by a mixture of seven different phases (hematite, goethite, sodalite, anatase, gibbsite, calcite, and amorphous). Finally in the interval of 1023–1523 K the following crystalline phases: hematite, nepheline, sodalite, anatase, perovskite, and pseudobrookite have been observed. 相似文献
27.
M. A. Gouveia M. I. Prudêncio J. M. P. Cabral 《Journal of Radioanalytical and Nuclear Chemistry》1988,124(1):227-233
Three Canadian reference rocks, syenites SY-2 and SY-3, and gabbro MRG-1 have been analysed for Na, K, Sc, Cr, Fe, Co, Zn, As, Rb, Cs, Ba, La, Ce, Nd, Sm, Eu, Tb, Yb, Lu, Hf, Ta and Th, by instrumental neutron activation analysis. The results are reported and compared with usable values. In general the agreement is good. 相似文献
28.
Parallel synthesis and high throughput dissolution testing of biodegradable polyanhydride copolymers
Vogel BM Cabral JT Eidelman N Narasimhan B Mallapragada SK 《Journal of combinatorial chemistry》2005,7(6):921-928
We have demonstrated that polycondensation reactions can be carried out in a combinatorial fashion and that the polymer library can be screened at high throughput using a rapid prototyping technique to fabricate multiwell substrates. A linearly varying compositional library of 100 different biodegradable polyanhydride random copolymers that are promising carriers for controlled drug delivery was designed, fabricated, and characterized by IR microscopy within a few hours. The polyanhydride copolymer library was based on 1,6-bis(p-carboxyphenoxy)hexane (CPH) and sebacic anhydride (SA) and was characterized with infrared microspectroscopy to determine the composition within each well. Since degradation and release rates depend on copolymer composition, we also developed new high-throughput methods to investigate drug release from this library of copolymers by designing specific wells for each task. A subset of this library was chosen, and a substrate was designed and fabricated to enable the synthesis and monitoring of dye dissolution from a range of polyanhydride copolymers in a parallel fashion using a CCD camera. Multisample substrates were fabricated with a novel rapid prototyping method that consists of an organic solvent-resistant array of 10 x 10 microwells of 2-muL volume each. The libraries were deposited with a custom-built liquid dispensing system consisting of a series of computer-controlled volume-dispensing pumps and XYZ motion stages. The parallel dye dissolution study displayed a decreasing rate of release with increasing CPH content. This result agrees with previously published data for dye release from poly(CPH-co-SA) copolymers. The methodology described in this work is amenable to numerous applications in the arenas of high-throughput polymer synthesis and characterization. 相似文献
29.
Abstract Evidence of rearrangement of 3-acyl derivatives of ascorbic acid to 2-acyl derivatives has been found for carbon and phosphorus acyl groups. The observations are consistent with intramolecular rearrangement through a cyclic intermediate in which the acyl group is bonded to both the 2- and 3-oxygen atoms of ascorbic acid. A rate of rearrangement has been measured for the 3-diphenylphosphinate ester. Calculated results indicate an increase in negative atomic charge at O-2 in the 3-acyl esters but a decrease in the charge of O-3 in the 2-acyl esters. 相似文献
30.
Raquel da Silva Cabral Andre L. L. Aquino Alejandro C. Frery Osvaldo A. Rosso Jaime A. Ramírez 《Central European Journal of Physics》2013,11(12):1645-1652
Wireless sensor networks are an important technology for making distributed autonomous measures in hostile or inaccessible environments. Among the challenges they pose, the way data travel among them is a relevant issue since their structure is quite dynamic. The operational topology of such devices can often be described by complex networks. In this work, we assess the variation of measures commonly employed in the complex networks literature applied to wireless sensor networks. Four data communication strategies were considered: geometric, random, small-world, and scale-free models, along with the shortest path length measure. The sensitivity of this measure was analyzed with respect to the following perturbations: insertion and removal of nodes in the geometric strategy; and insertion, removal and rewiring of links in the other models. The assessment was performed using the normalized Kullback-Leibler divergence and Hellinger distance quantifiers, both deriving from the Information Theory framework. The results reveal that the shortest path length is sensitive to perturbations. 相似文献