Enhancement of muramyldipeptide (MDP) immunostimulatory activity by controlled multimerization on dendrimers

Peptidoglycan is a widespread bacterial PAMP molecule and a powerful initiator of innate immune responses. It consists of repeating units of MDP, which as a monomer is only weakly immunostimulatory. Here, MDP-coupled dendrimers were prepared and investigated for stimulation of pig blood mononuclear cells. Compared to monomeric MDP, MDP-dendrimers induced a markedly enhanced production of IL-12 p40, IL-1β and IL-6 and completely down-regulated surface expression of B7 and MHC class II. These results suggest a possible novel strategy based on controlled multimerization of minimal PAMP motifs on dendrimers for preparing molecularly defined immunostimulators with predictable bioactivities.     

Model reduction of state space systems via an implicitly restarted Lanczos method

The nonsymmetric Lanczos method has recently received significant attention as a model reduction technique for large-scale systems. Unfortunately, the Lanczos method may produce an unstable partial realization for a given, stable system. To remedy this situation, unexpensive implicit restarts are developed which can be employed to stabilize the Lanczos generated model.This work was supported in part by ARPA (US Army ORA4466.01), by ARPA (Grant 60NANB2D1272), by the Department of Energy (Contract DE-FG0f-91ER25103) and by the National Science Foundation (Grants CCR-9209349 and CCR-9120008).     

Target fragmentation in proton-nucleus and16O-nucleus reactions at 60 and 200 GeV/nucleon

Target remnants withZ<3 from proton-nucleus and¹⁶O-nucleus reactions at 60 and 200 GeV/nucleon were measured in the angular range from 30° to 160° (?1.7<η<1.3) employing the Plastic Ball detector. The excitation energy of the target spectator matter in central oxygen-induced collisions is found to be high enough to allow for complete disintegration of the target nucleus into fragments withZ<3. The average longitudinal momentum transfer per proton to the target in central collisions is considerably higher in the case of¹⁶O-induced reactions (≈300 MeV/c) than in proton-induced reactions (≈130 MeV/c). The baryon rapidity distributions are roughly in agreement with one-fluid hydrodynamical calculations at 60 GeV/nucleon¹⁶O+Au but are in disagreement at 200 GeV/nucleon, indicating the higher degree of transparency at the higher bombarding energy. Both, the transverse momenta of target spectators and the entropy produced in the target fragmentation region are compared to those attained in head-on collisions of two heavy nuclei at Bevalac energies. They are found to be comparable or do even exceed the values for the participant matter at beam energies of about 1–2 GeV/nucleon.     

Constrainedn-person games

The usual properties of a characteristic function game were derived byvon Neumann andMorgenstern from the properties of a game in normal form. In this paper we give a linear programming principle for the calculation of the characteristic function. The principle is a direct application ofCharnes' linear programming method for the calculation of the optimal strategies and the value of a two-person zero-sum game. The linear programming principle gives another method for proving the standard properties of a characteristic function when it is derived from a game in normal form. Using an idea originated byCharnes for two person games, we develop the concept of a constrainedn-person game as a simple, practical extension of ann-person game. However the characteristic function for a constrainedn-person game may not satisfy properties, such as superadditivity, usually associated with a characteristic function.     

Effect of Pr-Ca substitution on the transport and magnetic behavior of LaMnO3 perovskite

The effect of simultaneous substitution of a fluctuating cation and a divalent cation in LaMnO₃ perovskite modifies the properties of the material to exhibit large valence colossal magnetoresistance (CMR) effect. A good example of these properties is (La_1−2x Pr _x Ca _x )MnO₃ (LPCMO) type CMR material. In this communication it is reported that, with the increase in x (for x=0.1, 0.15, 0.2), the T _c varies between 100 and 120 K with improvisation in metal-insulator transition. Interestingly, resistance increases with x from few hundred ohms to few kilo ohms with corresponding decrease in the unit cell volume. The results of the studies using X-ray diffraction (XRD), electrical resistivity, magnetoresistance and ac susceptibility measurements on LPCMO samples for understanding the structural, transport and magnetic properties are discussed in detail.     

Charged particle spectra in16O induced nuclear collisions at the CERN SPS

Charged particle multiplicity distributions and pseudo-rapidity density distributions from¹⁶O induced nuclear collisions at 200 and 60A GeV are presented. The data were taken, using a minimumbias trigger, with the WA80 set-up at the CERN SPS. In this presentation we focus on how the yield of charged particles depends on the projectile energy, the mass number of the target nucleus and the energy measured in a uranium-plastic sampling calorimeter covering angles close to zero degrees. The data are compared to simulations from the event generator FRITIOF.     

Simulation of critical fluid Rayleigh linewidth behavior by a normal fluid system

The dynamic droplet model of a critical fluid provides a simple physical model of a critical fluid. We use this to model an emulsion which mimics the Rayleigh linewidth behavior of a critical fluid in the nonhydrodynamic regime.     

Reversible transformations of gold nanoparticle morphology

Herein is reported a metamorphosis taking place in a gold nanosized system. The observed phenomenon of shape and size transformations was found to be completely reversible. Unlike most procedures in the literature where shape and size control occur in the synthetic step by adding growth- and shape-controlling agents such as surfactants or polymers, in this system postsynthetic changes in shape and size can be carried out simply by changing the ratio of reactive, competing reagents, more specifically, alkylthiols versus tetralkylammonium salts. Interestingly, the transfer of gold metal occurs (large prismatic particles to small particles and vice versa) under the influence of reagents that do not cause such interactions with bulk gold. All intermediate steps of the morphology change were observed using HRTEM and electron diffraction. The processes of breaking down and "welding back" solid metal nanoparticles occur under mild conditions and are remarkable examples of the unique chemical properties of nanomaterials. The described process is expected to be relevant to other nanoscale systems where similar structural circumstances could occur.