排序方式: 共有39条查询结果,搜索用时 15 毫秒
31.
32.
Z G Li R L Harlow C M Foris H Li P Ma R D Vickery M B Maurin B H Toby 《Microscopy and microanalysis》2002,8(2):134-138
Electron diffraction has been recently used in the pharmaceutical industry to study the polymorphism in crystalline drug substances. While conventional X-ray diffraction patterns could not be used to determine the cell parameters of two forms of the microcrystalline GP IIb/IIIa receptor antagonist roxifiban, a combination of electron single-crystal and synchrotron powder diffraction techniques were able to clearly distinguish the two polymorphs. The unit-cell parameters of the two polymorphs were ultimately determined using new software routines designed to take advantage of each technique's unique capabilities. The combined use of transmission electron microscopy (TEM) and synchrotron patterns appears to be a good general approach for characterizing complex (low-symmetry, large-unit-cell, micron-sized) polymorphic pharmaceutical compounds. 相似文献
33.
LL Handley R Azcón Ruiz Lozano JM CM Scrimgeour 《Rapid communications in mass spectrometry : RCM》1999,13(13):1320-1324
It has long been evident that plant (15)N chiefly reflects the processes which fractionate (15)N/(14)N rather than the (15)N of plant N source(s). It has emerged recently that one of the most important fractionating processes contributing to the whole plant (15)N is the presence/absence, type or species of mycorrhiza, especially when interacting with nutrient deficiency. Ecto- and ericoid mycorrhizas are frequently associated with (15)N-depleted foliar (15)N, commonly as low as -12 per thousand. As shown by the present study, plants having no mycorrhiza, or those infected with various species of arbuscular mycorrhiza (AM)-forming fungi, interact with varying concentrations of soil nitrogen [N] and moisture to enrich plant (15)N by as much as 3.5 per thousand. Hence the lack of a mycorrhiza, or variation in the species of AM-forming fungal associations, can account for about 25% of the usually reported variations of foliar (15)N found in field situations and do so by (15)N enrichment rather than depletion. Copyright 1999 John Wiley & Sons, Ltd. 相似文献
34.
35.
36.
Single crystals of Pb2P2O7 have been grown by the Czochralski technique. They have the triclinic space group with cell dimensions a = 6.9627 Å, b = 6.9754Å, c = 12.764 Å, α = 96.78°, β = 91.16°, γ = 89.68°. There are four molecules per unit cell. Dielectric properties for this compound have been measured and are discussed. 相似文献
37.
B Anuradha CM Santosh V Hari Sai Priya G Suman Latha KJR Murthy Valluri Vijaya Lakshmi 《Journal of immune based therapies and vaccines》2007,5(1):8-7
Background
Mycobacterium bovis BCG vaccine has displayed inconsistent efficacy in different trials conducted in various geographical regions. Nevertheless, it significantly reduces the risk of severe childhood tuberculosis and continues to be used to prevent tuberculosis in many countries. Many studies revealed that efficacy of vaccine wanes with age. Most of the studies were based on in vivo and in vitro responses to tuberculin. With the advent of newer tests such as in vitro interferon-γ assays and identification of potent immunogenic mycobacterial proteins there is a need to corroborate the observations. This study aims at ascertaining the need for a booster at a later age as indicated by in vitro release of IFN-γ while evaluating Ag85A as an antigen. 相似文献38.
Marijke WA de Backer Maike AD Brans Mieneke CM Luijendijk Keith M Garner Dianne MA van den Heuvel R Jeroen Pasterkamp Roger AH Adan 《BMC neuroscience》2010,11(1):94
Background
Multiple neuropeptides, sometimes with opposing functions, can be produced from one precursor gene. To study the roles of the different neuropeptides encoded by one large precursor we developed a method to overexpress minigenes and establish local secretion. 相似文献39.