首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   228篇
  免费   15篇
  国内免费   2篇
化学   204篇
晶体学   9篇
力学   2篇
数学   8篇
物理学   22篇
  2023年   2篇
  2022年   14篇
  2021年   14篇
  2020年   11篇
  2019年   18篇
  2018年   12篇
  2017年   8篇
  2016年   17篇
  2015年   10篇
  2014年   10篇
  2013年   10篇
  2012年   15篇
  2011年   19篇
  2010年   10篇
  2009年   13篇
  2008年   10篇
  2007年   8篇
  2006年   7篇
  2005年   7篇
  2004年   9篇
  2003年   1篇
  2002年   1篇
  2001年   2篇
  2000年   1篇
  1993年   1篇
  1992年   1篇
  1991年   2篇
  1989年   2篇
  1988年   1篇
  1984年   2篇
  1983年   1篇
  1979年   1篇
  1977年   2篇
  1971年   2篇
  1969年   1篇
排序方式: 共有245条查询结果,搜索用时 15 毫秒
91.
ABSTRACT: BACKGROUND: Aerva javanica (Burm. f.) Juss. ex Schult. (Amaranthacea) is traditionally used for the treatment of wound healings, cough, diarrhoea, ulcer and hyperglycaemia. The current study was aimed to fractionate and isolate bioactive compounds and ultimately to evaluate their anti-ulcereogenic potential. RESULTS: In order to achieve these aims, the fractionation, purifications and then biological potential determination of the isolated compounds was carried out. For purification purpose, initially extraction of the plant material was done with aqueous MeOH in the order of increasing polarity by using solvent-solvent extraction method. Phytochemical analysis revealed the presence of three compounds, 3-hydroxy-4 methoxybenzaldehyde (1), ursolic acid (2) and (E)-N-(4-hydroxy-3-methoxyphenethyl)-3-(4-hydroxy-3-ethoxyphenyl) acryl amide (3). Inhibition of urease activity of various fractions revealed that ethyl acetate fraction showed significant activity (P <0.05) as compared to other fractions. (E)-N-(4-hydroxy-3- methoxyphenethyl)-3-(4-hydroxy-3-ethoxyphenyl) acryl amide (3) showed marked anti ulcer activity (P <0.05). CONCLUSION: These results suggested the mild potential of A. javanica against ulcer.  相似文献   
92.
A systematic study of the product((E(2_2~+)/E(2_1~+))*B(E2)↑) is carried out in the major shell space Z=50-82,N=82-126 within the framework of the asymmetric rotor model where the asymmetry parameter γ0reflects change in the nuclear structure.A systematic study of the product((E(2+)/E(2+))*B(E2)↑) with neutron number N is also discussed.The product((E(2_2~+)/E(2_1~+))*B(E2)↑) provides a direct correlation with the asymmetry parameter γ0.The effect of subshells is visible in Ba-Gd nuclei with N 82,but not in Hf-Pt nuclei with N 104.We study,for the first time,the dependency of the product((E(2_2~+)/E(2_1~+))*B(E2)↑) on the asymmetry parameterγ0.  相似文献   
93.
We examine the effect of dissipation on travelling waves in nonlinear dispersive systems modelled by Benjamin–Bona–Mahony (BBM)-like equations. In the absence of dissipation, the BBM-like equations are found to support soliton and compacton /anticompacton solutions depending on whether the dispersive term is linear or nonlinear. We study the influence of increasing nonlinearity of the medium on the soliton and compacton dynamics. The dissipative effect is found to convert the solitons either to undular bores or to shock-like waves depending on the degree of nonlinearity of the equations. The anticompacton solutions are also transformed to undular bores by the effect of dissipation. But the compactons tend to vanish due to viscous effects. The local oscillatory structures behind the bores and /or shock-like waves in the case of solitons and anticompactons are found to depend sensitively both on the coefficient of viscosity and solution of the unperturbed problem.  相似文献   
94.
Lysozyme is often used as a model protein to study interaction with drug molecules and to understand biological processes which help in illuminating the therapeutic effectiveness of the drug. In the present work, in vitro interaction studies of 1-{(2-hydroxyethyl)amino}-2-amino-1,2-dideoxy-d-glucose triphenyl tin (IV) (GATPT) complex with lysozyme were carried out by employing various biophysical methods such as absorption, fluorescence, and circular dichroism (CD) spectroscopies. The experimental results revealed efficient binding affinity of GATPT with lysozyme with intrinsic binding (Kb) and binding constant (K) values in the order of 105 M−1. The number of binding sites and thermodynamic parameters ΔG, ΔH, and ΔS at four different temperatures were also calculated and the interaction of GATPT with lysozyme was found to be enthalpy and entropy driven. The CD spectra revealed alterations in the population of α–helical content within the secondary structure of lysozyme in presence of GATPT complex. The morphological analysis of the complex with lysozyme and lysozyme-DNA condensates was carried out by employing confocal and SEM studies. Furthermore, the molecular docking studies confirmed the interaction of GATPT within the larger hydrophobic pocket of the lysozyme via several non-covalent interactions.  相似文献   
95.
96.
Natural products derived from marine sponges have exhibited bioactivity and, in some cases, serve as potent quorum sensing inhibitory agents that prevent biofilm formation and attenuate virulence factor expression by pathogenic microorganisms. In this study, the inhibitory activity of the psammaplin-type compounds, psammaplin A (1) and bisaprasin (2), isolated from the marine sponge, Aplysinella rhax, are evaluated in quorum sensing inhibitory assays based on the Pseudomonas aeruginosa PAO1 lasB-gfp(ASV) and rhlA-gfp(ASV) biosensor strains. The results indicate that psammaplin A (1) showed moderate inhibition on lasB-gfp expression, but significantly inhibited the QS-gene promoter, rhlA-gfp, with IC50 values at 14.02 μM and 4.99 μM, respectively. In contrast, bisaprasin (2) displayed significant florescence inhibition in both biosensors, PAO1 lasB-gfp and rhlA-gfp, with IC50 values at 3.53 μM and 2.41 μM, respectively. Preliminary analysis suggested the importance of the bromotyrosine and oxime functionalities for QSI activity in these molecules. In addition, psammaplin A and bisaprasin downregulated elastase expression as determined by the standard enzymatic elastase assay, although greater reduction in elastase production was observed with 1 at 50 μM and 100 μM. Furthermore, the study revealed that bisaprasin (2) reduced biofilm formation in P. aeruginosa.  相似文献   
97.
Plants are an important source of drug development and numerous plant derived molecules have been used in clinical practice for the ailment of various diseases. The Toll-like receptor-4 (TLR-4) signaling pathway plays a crucial role in inflammation including rheumatoid arthritis. The TLR-4 binds with pro-inflammatory ligands such as lipopolysaccharide (LPS) to induce the downstream signaling mechanism such as nuclear factor κappa B (NF-κB) and mitogen activated protein kinases (MAPKs). This signaling activation leads to the onset of various diseases including inflammation. In the present study, 22 natural compounds were studied against TLR-4/AP-1 signaling, which is implicated in the inflammatory process using a computational approach. These compounds belong to various classes such as methylxanthine, sesquiterpene lactone, alkaloid, flavone glycosides, lignan, phenolic acid, etc. The compounds exhibited different binding affinities with the TLR-4, JNK, NF-κB, and AP-1 protein due to the formation of multiple hydrophilic and hydrophobic interactions. With TLR-4, rutin had the highest binding energy (−10.4 kcal/mol), poncirin had the highest binding energy (−9.4 kcal/mol) with NF-κB and JNK (−9.5 kcal/mol), respectively, and icariin had the highest binding affinity (−9.1 kcal/mol) with the AP-1 protein. The root means square deviation (RMSD), root mean square fraction (RMSF), and radius of gyration (RoG) for 150 ns were calculated using molecular dynamic simulation (MD simulation) based on rutin’s greatest binding energy with TLR-4. The RMSD, RMSF, and RoG were all within acceptable limits in the MD simulation, and the complex remained stable for 150 ns. Furthermore, these compounds were assessed for the potential toxic effect on various organs such as the liver, heart, genotoxicity, and oral maximum toxic dose. Moreover, the blood–brain barrier permeability and intestinal absorption were also predicted using SwissADME software (Lausanne, Switzerland). These compounds exhibited promising physico-chemical as well as drug-likeness properties. Consequently, these selected compounds portray promising anti-inflammatory and drug-likeness properties.  相似文献   
98.
99.
The interaction of various flavonoids (compounds having C6-C3-C6 configuration) with sodium dodecyl sulfate (SDS) an anionic surfactant was studied through absorption spectroscopy as a function of the concentration of surfactant above and below the critical micelle concentration (CMC) of the surfactant. A mechanism was proposed for the interaction between these flavonoids and anionic surfactants. The approximate number of additive molecules (flavonoids) incorporated per micelle was estimated at a particular concentration of SDS. Incorporation of additive in micelles shifts the UV absorption bands towards higher wavelengths of different magnitude. The spectral shift also depends upon the nature of the surfactant head group. The absorption spectra of the flavonoids in aqueous solution and in methanol are also reported.  相似文献   
100.
The present work focuses on the clouding phenomenon in an amphiphilic drug [amitriptyline (AMT), which is a tricyclic antidepressant] solution. A 50-mM AMT solution prepared in 10 mM of sodium phosphate (SP) buffer was taken where the cloud point (CP) was found to decrease with increasing pH. The same CP decreasing trend (with pH increase) followed in the presence of a fixed concentration (50 mM) of added salts [NaBr, and tetra-n-butylammonium bromide (TBuAB)]. The addition of increasing amounts of quaternary bromides (tetramethylammonium bromide, tetraethylammonium bromide, tetra-n-propylammonium bromide, TBuAB, and tetra-n-pentylammonium bromide) to 50 mM of AMT solution (prepared in 10 mM of SP buffer) caused continuous increase in CP, which was found to be dependent upon the alkyl chain length of that particular salt. The similar type of CP increase was also observed in the presence of conventional (cetyltrimethylammonium bromide and tetradecyltrimethylammonium bromide) and gemini surfactants [bis(hexadecyldimethylammonium)hexane, bis(hexadecyldimethylammonium)pentane, and bis(hexadecyldimethylammonium)butane]. The overall behavior was discussed in terms of electrostatic interactions, micellar growth, and mixed micelle formation.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号