A hybrid material with excellent mechanical and biological properties is produced by electrospinning a co‐solution of PET and collagen. The fibers are mapped using SEM, confocal Raman microscopy and collagenase digestion assays. Fibers of different compositions and morphologies are intermingled within the same membrane, resulting in a heterogeneous scaffold. The collagen distribution and exposure are found to depend on the PET/collagen ratio. The materials are chemically and mechanically characterized and biologically tested with fibroblasts (3T3‐L1) and a HUVEC culture in vitro. All of the hybrid scaffolds show better cell attachment and proliferation than PET. These materials are potential candidates to be used as vascular grafts.
An upper rim-functionalised calix[4]arene dicarboxylic acid (H(2)caldc) has been used to prepare four metal-organic frameworks, three of which have been structurally characterised and shown to form two- or three-dimensional network structures. Simulations suggest that such networks are likely to display interesting selectivity to guest molecules. 相似文献
Optical multichannel detectors like photodiode arrays or CCD cameras combined with grating spectrometers are commonly used as detection systems in quantitative absorption spectroscopy. As a trade-off to broad spectral coverage, banded spectral features are sometimes recorded with insufficient spectral resolution and/or insufficiently fine detector binning. This renders the true physical spectrum of recorded intensities changed by instrumental and spectrum specific artefacts thus impeding comparability between results from different set-ups. In this work, it is demonstrated that in the case of a "well-behaved"--i.e. free of ro-vibronic structure--absorption band like the iodine monoxide IO(4<--0) transition, these effects can easily change the apparent peak absorption by up to 50%. Also deviations from the strict linearity (Beer-Lambert's law) between absorber concentration and apparent, i.e. pixelwise optical density occur. This can be critical in studies of chemical kinetics. It is shown that the observed non-linearity can cause errors of up to 50% in the determination of a second order rate coefficient for the IO self reaction. To overcome the problem, a consistent and rigorous integral approach for the treatment of intensity recordings is developed. Linearity between optical density and absorber concentration thereby is re-established. The method is validated using artificial test data as well as experimental data of the IO(4<--0) absorption transition, obtained in the context of I2/O3 photochemistry studies. The agreement is accurate to within +/-2% (test data) and +/-3% (experimental data) supporting the validity of the approach. Possible consequences for other spectroscopic work are indicated. 相似文献
A full spectrum fitting code, developed and used by the Bath positron group to compute the fractions of positrons annihilated from surface, defect and bulk states as a function of incident positron energy, is described. To date, the most useful application of the code has been in studies of ion-implanted silicon, being particularly useful in the observation of the formation of oxygen-divacancy complexes. The advantages and limitations of the code are discussed. 相似文献
A variety of terminal chain modifications (Y) were made on the diacetylenes in which X=CnH2n+1, C12H25O and F, and Y=CH2CH(Me)C2H5, COCH3, C≡CC5H11, CnF2n+1CnH2n+1 and CH=CHCO2C3H7. Mesomorphic properties were determined by hot stage polarizing microscopy and DSC. These were compared with those for the dialkyl analogues (X=CmH2m+1, Y=CnH2n+1) and a series of 1- and 2-olefins (Y=CH=CHCnH2n+1 and CH2CH=CHCnH2n+1). The 1-olefin series showed wider range nematics than the dialkyl compounds, whereas the above modifications showed either narrow range nematic phases, no mesophase or higher melting temperatures. New transition temperature and enthalpy data are provided for some of the dialkyl and F-alkyl compounds previously reported, for comparisons. Preliminary birefringence data are also included along with the results of some heat and UV stability studies. 相似文献
The square-planar, macrocyclic complex NiCR (CR=(2,12-dimethyl-3,7,11,17-tetraazabicyclo[11.3.1]heptadeca-1(17),2,11,13,15-pentaenato)) as well as CoCl 2 have been investigated as catalysts for the site-specific oxidation of bulged T, C, and A nucleotides in duplex DNA oligomers. Previous studies of NiCR using KHSO 5 as oxidant indicated that this combination of reagents successfully probes the accessibility of N7 of guanine residues in non-canonical DNA and folded RNA structures. In the present study, the order of reactivity of bulged bases in synthetic oligodeoxynucleotides with NiCR/KHSO 5 is shown to be G>C>T~A. Although the nickel complex generates a less-reactive oxidant than does cobalt, its selectivity for bulged bases is much greater, rendering it a useful probe of exposed Cs and Ts in addition to Gs in DNA and RNA structure. 相似文献