全文获取类型
收费全文 | 105篇 |
免费 | 6篇 |
专业分类
化学 | 65篇 |
力学 | 10篇 |
物理学 | 36篇 |
出版年
2022年 | 1篇 |
2021年 | 10篇 |
2020年 | 3篇 |
2019年 | 15篇 |
2018年 | 4篇 |
2017年 | 6篇 |
2016年 | 14篇 |
2015年 | 3篇 |
2014年 | 2篇 |
2013年 | 6篇 |
2012年 | 8篇 |
2011年 | 7篇 |
2010年 | 5篇 |
2008年 | 1篇 |
2007年 | 2篇 |
2006年 | 5篇 |
2005年 | 4篇 |
2004年 | 2篇 |
2003年 | 2篇 |
2002年 | 1篇 |
1998年 | 2篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有111条查询结果,搜索用时 15 毫秒
41.
42.
Dr. André A. Neves Dr. Yéléna A. Wainman Dr. Alan Wright Dr. Mikko I. Kettunen Dr. Tiago B. Rodrigues Sarah McGuire Dr. De‐En Hu Flaviu Bulat Dr. Simonetta Geninatti Crich Dr. Henning Stöckmann Dr. Finian J. Leeper Prof. Kevin M. Brindle 《Angewandte Chemie (International ed. in English)》2016,55(4):1286-1290
Glycosylation is a ubiquitous post‐translational modification, present in over 50 % of the proteins in the human genome, 1 with important roles in cell–cell communication and migration. Interest in glycome profiling has increased with the realization that glycans can be used as biomarkers of many diseases, 2 including cancer. 3 We report here the first tomographic imaging of glycosylated tissues in live mice by using metabolic labeling and a gadolinium‐based bioorthogonal MRI probe. Significant N‐azidoacetylgalactosamine dependent T1 contrast was observed in vivo two hours after probe administration. Tumor, kidney, and liver showed significant contrast, and several other tissues, including the pancreas, spleen, heart, and intestines, showed a very high contrast (>10‐fold). This approach has the potential to enable the rapid and non‐invasive magnetic resonance imaging of glycosylated tissues in vivo in preclinical models of disease. 相似文献
43.
44.
45.
Andrey Filippov Bulat Munavirov Bulat Gizatullin Oleg N. Antzutkin 《Magnetic resonance in chemistry : MRC》2013,51(1):1-3
We present a 31P NMR spectroscopy study of planar glass‐plate‐oriented multi‐bilayers of dimyristoylphosphatidylcholine (DMPC) with addition of polyethylene oxide (PEO). This work revealed the presence of a new component in the spectra that appeared only with addition of a small fraction of PEO (up to one PEO segment per dimyristoylphosphatidylcholine molecule) and disappeared when larger amounts of PEO were added. We explained this phenomenon as an effect of an inhomogeneous force field induced by the PEO molecules located at a certain depth in the lipid membrane interface region. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
46.
47.
A. V. Sakharova A. V. Filippov B. V. Munavirov V. D. Skirda 《Russian Journal of Physical Chemistry A, Focus on Chemistry》2011,85(4):573-583
Transverse relaxation and self-diffusion of molecules in a glyceryl monooleate (monoolein)-D2O system was studied using pulsed 1H NMR in a range of water concentrations from 10 to 30 wt % and a range of temperatures from 20 to 90°C. It was noted that
self-diffusion is described by one or two self-diffusion coefficients, depending on the temperature and concentration of water,
while NMR-relaxation has a complex form. It was determined that with a reduction in the transverse magnetization, a component
that has a form similar to Gaussian and relaxation times of 70 to 250 μs is observed at certain temperatures and concentrations
of water, confirming the formation of structures in which glyceryl monooleate molecules (GM) are characterized by anisotropic
rotational mobility. It was demonstrated that the ranges of the concentrations of water and temperature in which this component
is observed correspond to liquid-crystalline phase for lamellar and inverse hexagonal structural organizations of lipids,
according to the state diagram obtained by X-ray diffraction. In the state diagram areas corresponding to micellar and cubic
structures (characterized by the isotropic rotation of GM molecules in the time scale of NMR), multiexponential decays of
magnetization with average relaxation times were noted in the range of 10 to 200 ms. A number of features were discovered
with the use of NMR: specimens always contain structures with isotropic rotational mobility in the presence of structures
characterized by anisotropic rotational mobility; a change in the fraction of the structures with anisotropic rotational mobility
takes place slowly over 5–15 K, not abruptly. Our conclusions regarding the polymorphism of a GM-D2O system in the presence of anisotropic structures was confirmed by an analysis of the transverse NMR relaxation in an egg
phosphatidylcholine-D2O system, for which the presence of only lamellar liquid-crystalline structure is confirmed by 31P NMR. 相似文献
48.
Sharipov Bulat T. Davidova Anna N. Ryabova Alena S. Galimzyanova Nailya F. Valeev Farid A. 《Chemistry of Heterocyclic Compounds》2019,55(1):31-37
Chemistry of Heterocyclic Compounds - A series of derivatives were synthesized on the basis of levoglucosenone that contained hydroxy groups at the С-4 atom or С-2 and С-4 atoms... 相似文献
49.
International Applied Mechanics - An energy failure criterion for thermoviscoelastic structural members subject to abrasive wear and dissipative heating is proposed. The criterion is used to... 相似文献
50.
Vincent M. Morin Dr. Patrick M. J. Szell Estelle Caron-Poulin Dr. Bulat Gabidullin Prof. Dr. David L. Bryce 《ChemistryOpen》2019,8(11):1328-1336
The halogen bond has previously been explored as a versatile tool in crystal engineering and anion coordination chemistry, with mechanochemical synthetic techniques having been shown to provide convenient routes towards cocrystals. In an effort to expand our knowledge on the role of halogen bonding in anion coordination, here we explore a series of cocrystals formed between 3-iodoethynylpyridine and 3-iodoethynylbenzoic acid with halide salts. In total, we report the single-crystal X-ray structures of six new cocrystals prepared by mechanochemical ball milling, with all structures exhibiting C≡C−I⋅⋅⋅X− (X=Cl, Br) halogen bonds. Whereas cocrystals featuring a pyridine group favoured the formation of discrete entities, cocrystals featuring a benzoic acid group yielded an alternation of halogen and hydrogen bonds. The compounds studied herein were further characterized by 13C and 31P solid-state nuclear magnetic resonance, with the chemical shifts offering a clear and convenient method of identifying the occurrence of halogen bonding, using the crude product obtained directly from the mechanochemical ball milling. Whereas the 31P chemical shifts were quickly able to identify the occurrence of cocrystallization, 13C solid-state NMR was diagnostic of both the occurrence of halogen bonding and of hydrogen bonding. 相似文献