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排序方式: 共有344条查询结果,搜索用时 15 毫秒
121.
Paul D. Chastain II Bruna P. Brylawski Yingchun C. Zhou Shangbang Rao Haitao Chu Joseph G. Ibrahim William K. Kaufmann Marila Cordeiro‐Stone 《Photochemistry and photobiology》2015,91(1):109-116
We investigated the hypothesis that the strength of the activation of the intra‐S DNA damage checkpoint varies within the S phase. Synchronized diploid human fibroblasts were exposed to either 0 or 2.5 J m?2 UVC in early, mid‐ and late‐S phase. The endpoints measured were the following: (1) radio‐resistant DNA synthesis (RDS), (2) induction of Chk1 phosphorylation, (3) initiation of new replicons and (4) length of replication tracks synthesized after irradiation. RDS analysis showed that global DNA synthesis was inhibited by approximately the same extent (30 ± 12%), regardless of when during S phase the fibroblasts were exposed to UVC. Western blot analysis revealed that the UVC‐induced phosphorylation of checkpoint kinase 1 (Chk1) on serine 345 was high in early and mid S but 10‐fold lower in late S. DNA fiber immunostaining studies indicated that the replication fork displacement rate decreased in irradiated cells at the three time points examined; however, replicon initiation was inhibited strongly in early and mid S, but this response was attenuated in late S. These results suggest that the intra‐S checkpoint activated by UVC‐induced DNA damage is not as robust toward the end of S phase in its inhibition of the latest firing origins in human fibroblasts. 相似文献
122.
Elzalina R. Soares Richardson A. de Almeida Bruna R. de Lima Hector H.F. Koolen Caroline C. Lourenço 《Natural product research》2015,29(13):1285-1288
Essential oils from the leaves, twigs and barks of Bocageopsis pleiosperma Maas were obtained by using hydrodistillation and analysed by using gas chromatography coupled to mass spectrometry. Several compounds (51) were detected and identified, being β-bisabolene the main component in all aerial parts of the plant, with higher concentration in the leaves (55.77%), followed by barks (38.53%) and twigs (34.37%). In order to increase the biological knowledge about the essential oil of Bocageopsis species, antimicrobial activities were evaluated against the microorganisms Escherichia coli, Staphylococcus epidermidis, Enterobacter aerogenes, Candida tropicalis, Candida dubliniensis, Candida glabrata and Candida albicans. The essential oil obtained from the barks exhibited a moderate effect against S. epidermidis ATCC 1228 (MIC = 250 μg/mL), while the other oils did not exhibit antimicrobial activity. These results represent the first report about the chemical composition of B. pleiosperma and the first antimicrobial evaluation with a Bocageopsis species. 相似文献
123.
de Andrade BB Moreira MR Ambrosio SR Furtado NA Cunha WR Heleno VC Silva AN Simão MR da Rocha EM Martins CH Veneziani RC 《Natural product communications》2011,6(6):777-780
Ent-kaur-16(17)-en-19-oic acid (kaurenoic acid, KA) is a tetracyclic diterpene prototype for natural anticaries agents. Six KA derivatives were prepared and their antimicrobial activity against the main microorganisms involved in the caries process evaluated. The sodium salt of KA (KA-Na) was the most active, displaying very promising MIC values for most pathogens. Time-kill assays against the primary causative agent of caries (Streptococcus mutans) indicated that KA and KA-Na only inhibited growth in the first 12 h, suggesting a bacteriostatic effect. After this period (12-24 h), their bactericidal effect was clearly noted. KA and KA-Na showed no synergy when combined with the gold standard anticariogenic (chlorhexidine dihydrochloride, CHD) in the checkerboard assays against S. mutans. 相似文献
124.
We present a theoretical model to determine the effective zeta potential ζ(eff) in microfluidic channels where an embedded, insulated gate electrode allows for external tuning of a portion of the channel surface charge. In addition, we derive a method to determine ζ(eff) in such channels, for any value of salt concentration, using the solution displacement technique. To do so, we simulate typical current-monitoring measurements using our model, and highlight the experimental parameters that lead to inaccurate results using this procedure with an heterogenous channel. Our method corrects for such inaccuracies by using our model with experimental data to find the correct value of ζ(eff) . Finally, we perform experiments to demonstrate our method and the use of our model with a silica-PMDS microchannel system with an embedded Ti-Au-Ti gate electrode that covers 50% of the bottom surface of the channel. We show that our theory captures the salient features of our experiments, thereby offering a useful tool to predict effective zeta potential in channels with a nonuniform zeta potential. 相似文献
125.
Bruna S. Santos Sandra C.C. Nunes Alberto A.C.C. Pais Teresa M.V.D. Pinho e Melo 《Tetrahedron》2012,68(19):3729-3737
Chiral spiro-β-lactam derivatives have been prepared via stereoselective 1,3-dipolar cycloaddition of 6-diazopenicillanates. Using dipolarophiles such as acrylonitrile, acrylates or methyl vinyl ketone spiro-2-pyrazoline-β-lactams were obtained, whereas the cycloaddition with N-substituted-maleimides afforded spiro-1-pyrazoline-β-lactams. 6-Diazopenicillanates also reacted with electron-deficient alkynes to give the corresponding spiro-3H-pyrazole-β-lactam as single product. The observed stereoselectivity can be explained considering that the major product results from the addition to the less sterically hindered α-side of the β-lactam. Microwave-induced denitrogenation of spiro-1-pyrazoline-β-lactams allowed the stereoselective synthesis of novel spirocyclopropyl-β-lactams. The rationalization of the observed selectivity was supported by electronic structure calculations. 相似文献
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128.
We show that the complete first order theory of an MV algebra has $2^{\aleph _0}$ countable models unless the MV algebra is finitely valued. So, Vaught's Conjecture holds for all MV algebras except, possibly, for finitely valued ones. Additionally, we show that the complete theories of finitely valued MV algebras are $2^{\aleph _0}$ and that all ω‐categorical complete theories of MV algebras are finitely axiomatizable and decidable. As a final result we prove that the free algebra on countably many generators of any locally finite variety of MV algebras is ω‐categorical. 相似文献
129.
Gadea A Lenzi SM Lunardi S Mărginean N Zuker AP de Angelis G Axiotis M Martínez T Napoli DR Farnea E Menegazzo R Pavan P Ur CA Bazzacco D Venturelli R Kleinheinz P Bednarczyk P Curien D Dorvaux O Nyberg J Grawe H Górska M Palacz M Lagergren K Milechina L Ekman J Rudolph D Andreoiu C Bentley MA Gelletly W Rubio B Algora A Nacher E Caballero L Trotta M Moszyński M 《Physical review letters》2006,97(15):152501
Gamma decays from excited states up to Jpi=6+ in the N=Z-2 nucleus 54Ni have been identified for the first time. Level energies are compared with those of the isobars 54Co and 54Fe and of the cross-conjugate nuclei of mass A=42. The good but puzzling f7/ cross-conjugate symmetry in mirror and triplet energy differences is analyzed. Shell model calculations reproduce the new data but the necessary nuclear charge-dependent phenomenology is not fully explained by modern nucleon-nucleon potentials. 相似文献
130.
Assessment of chemical elements in cosmetics' eyeshadows by X‐ray fluorescence and International Nomenclature of Cosmetic Ingredients characterization
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Bruna Vilela Santos José Martins de Oliveira Júnior Waldemar Bonventi Júnior Valquíria Miwa Hanai‐Yoshida 《X射线光谱测定》2018,47(3):242-251
Energy dispersive X‐ray fluorescence (EDXRF) technique, as a qualitative and quantitative analysis, was used for inorganic chemical elements determination (K, S, Cl, Al, Si, Ca, Ti, Mn, Fe, Pb, Zn, Rb, and Bi) in eyeshadows for safe human use. International Nomenclature of Cosmetic Ingredients standardized nomenclature was used for labels investigation to obtain data on legal regularity. Data of 23 samples were clustered by similarity, measuring relative concentrations of detected chemical elements. Calculating the correlation among such values, a similarity matrix was used to generate a dendrogram. Pb was found in samples silver color S12E and copper color S22I above permissible limits (20 μg/g). Same composition was reported for the pink (S01A), black (S02A), and brown (S03A) samples, but the same chemical elements were not detected by EDXRF in them. The best correlation was found between samples S08D and S23 J (0.961). The least correlation was 0.0012 between S01A and S12E. The clustering analysis showed 7 groups of similar samples according to EDXRF data. Relations among 6 eyeshadows' colors and chemical compositions were discovered by using decision trees, where the most determinant elements were Mn, S, Cl, Ca, and Fe, in this order. Commercial regularization and International Nomenclature of Cosmetic Ingredients standardization of eyeshadows in Brazil are not fully complied by the manufacturers of the investigated brands. 相似文献