A nonperturbative description ofN \bar N annihilation

A nonperturbative picture ofN \(\bar N\) annihilation is proposed. In particular, different parts of the nucleon and the antinucleon do not behave independently, but are tied together by their topological charge. We describe theN \(\bar N\) state as a coherent soliton-antisoliton configuration, and argue that vector mesons play an important role in the decay process. SomeS-wave selection rules are derived. Their relevance to the present LEAR experiments is discussed.     

A convenient synthesis of a selective gelatinase inhibitor as an antimetastatic agent

Compound 1, 2-(4-phenoxyphenylsulfonylmethyl)thiirane, is a potent and selective inhibitor for human gelatinases (J. Am. Chem. Soc. 2000, 122, 6799-6800), enzymes implicated in a number of diseases, including cancer. This compound is showing excellent promise in animal trials in a number of disease models. Large quantities of this compound were necessary for these studies. A convenient four-step synthetic route for compound 1 is described herein. The synthesis is amenable to scale-up to tens of grams and gives an overall yield of 57% for this important compound.