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排序方式: 共有810条查询结果,搜索用时 31 毫秒
801.
Rademacher C Guiard J Kitov PI Fiege B Dalton KP Parra F Bundle DR Peters T 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(27):7442-7453
Noroviruses attach to their host cells through histo blood group antigens (HBGAs), and compounds that interfere with this interaction are likely to be of therapeutic or diagnostic interest. It is shown that NMR binding studies can simultaneously identify and differentiate the site for binding HBGA ligands and complementary ligands from a large compound library, thereby facilitating the design of potent heterobifunctional ligands. Saturation transfer difference (STD) NMR experiments, spin-lock filtered NMR experiments, and interligand NOE (ILOE) experiments in the presence of virus-like particles (VLPs), identified compounds that bind to the HBGA binding site of human norovirus. Based on these data two multivalent prototype entry-inhibitors against norovirus infection were synthesized. A surface plasmon resonance based inhibition assay showed avidity gains of 1000 and one million fold over a millimolar univalent ligand. This suggests that further rational design of multivalent inhibitors based on our strategy will identify potent entry-inhibitors against norovirus infections. 相似文献
802.
803.
Nohra B El Moll H Rodriguez Albelo LM Mialane P Marrot J Mellot-Draznieks C O'Keeffe M Ngo Biboum R Lemaire J Keita B Nadjo L Dolbecq A 《Journal of the American Chemical Society》2011,133(34):13363-13374
The grafting of the triangular 1,3,5-benzene tricarboxylate linkers (denoted trim) on tetrahedral ε-Keggin polyoxometalates (POMs) capped by Zn(II) ions, formed in situ under hydrothermal conditions, has generated three novel POM-based metal organic frameworks (POMOFs). (TBA)(3)[PMo(V)(8)Mo(VI)(4)O(36)(OH)(4)Zn(4)][C(6)H(3)(COO)(3)](4/3)·6H(2)O (ε(trim)(4/3)) is a 3D open-framework built of molecular Keggin units connected by trim linkers, with channels occupied by tetrabutylammonium (TBA) counterions. ε(trim)(4/3) is a novel (3,4)-connected net, named ofp for open-framework polyoxometalate, and computer simulations have been used to evaluate its relative stability in comparison with ctn- and bor-like polymorphs, showing the stability of this novel phase directly related to its greatest density. A computational study was also undertaken with the aim of locating TBA molecules, the positions of which could not be deduced from single crystal X-ray diffraction, and further rationalizes their structure directing role. In (TBA)(3)[PMo(V)(8)Mo(VI)(4)O(37)(OH)(3)Zn(4)][C(6)H(3)(COO)(3)] (ε(2)(trim)(2)), the building unit is not the molecular Keggin but a dimerized form of this POM. Their connection via trim linkers generates a 3D framework with channels filled by TBA cations. In (TBA)(3)[PMo(V)(8)Mo(VI)(4)O(37)(OH)(3)Zn(4)][C(6)H(3)(COO)(3)]·8H(2)O ([ε(trim)](∞)), zigzag chains are connected via the organic linkers, forming 2D grids. Modified electrodes were fabricated by direct adsorption of the POMOFs on glassy carbon or entrapment in carbon paste (CPE). A remarkable electrocatalytic hydrogen evolution reaction (HER) was detected with a yield greater than 95%, and a turnover number as high as 1.2 × 10(5) was obtained after 5 h. The reported POMOF-based electrodes are more active than platinum, with a roughly 260 mV anodic shift. Finally, the electrocatalytic activities of ε(trim)(4/3)/CPE electrodes in various XCl (X = Li, Na, K, Cs) media have been studied. This allowed us to detect a cation effect and propose an electrocatalytic mechanistic pathway for the HER. 相似文献
804.
Several new co‐poly(arylene ether sulfone)s have been prepared by the reaction of 4,4′‐fluorodiphenyl sulfone (FDS) with different bisphenols namely 4,4′‐isopropylidenediphenol (BPA), 4,4′‐hexafluoroisopropylidenediphenol (6F‐BPA), and N‐phenyl‐3,3‐bis(4‐hydroxyphenyl)phthalimidine(PA). The homo‐poly(arylene ether sulfone)s are named as 1a, 2a, and 3a. The copolymers namely 2b, 2c, 2d and 3b, 3c, 3d have been prepared, respectively, on reaction of FDS with BPA or 6F‐BPA using different molar ratios of PA such as 25, 50, and 75. The poly(aryl ether sulfone)s 1a containing PA unit in the main chain showed a very high glass transition temperature of 280°C and an outstanding thermal stability up to 510°C for 5% weight loss under synthetic air. Depending on the mole% of PA, the glass transition temperatures of the copolymers can be varied. The polymers were soluble in a wide range of organic solvents. Transparent thin films of these polymers exhibited tensile strengths upto 84 MPa and Young's modulus up to 3.16 GPa. The films of these polymers showed low water absorption of 0.24%. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
805.
806.
Axel R. Brenner Brigitte I. Voit Dennis J. Massa S. Richard Turner 《Macromolecular Symposia》1996,102(1):47-54
Several hyperbranched polyesters have been prepared in a one-pot polycondensation reaction. Molecular weights, viscosities and rheological behavior of these polymers have been characterized. The influence of their terminal groups on the properties and their behavior in blends will be discussed. 相似文献
807.
Markus Antonietti Rimantas Kublickas Oskar Nuyken Brigitte Voit 《Macromolecular rapid communications》1997,18(4):287-294
Low-molar-mass surfactants (S) and polyelectrolytes (PE) containing diazosulfonate chromophores which are photo-labile and electrically charged were used for the formation of polyelectrolyte/surfactant complexes (PESC) in combination with commonly used polyelectrolytes and surfactants. The stable complexes are no longer water-soluble and were characterized by means of nuclear magnetic resonance spectroscopy and in some cases by means of gel-permeation chromatography measurements. Complexes with a 1 : 1 stoichiomctry with respect to charge are formed. Ultraviolet irradiation of the photo-labile PESC resulted in the loss of the ionic interactions. 相似文献
808.
809.
Veera Bhadraiah Sadhu Jürgen Pionteck Dieter Voigt Hartmut Komber Brigitte Voit 《Macromolecular Symposia》2004,210(1):147-155
In order to obtain amino-terminated polymethyl methacrylate (PMMA-NH2) free of halogen we used the atom transfer radical polymerization (ATRP) to polymerize methyl methacrylate (MMA) in presence of an initiator containing an alkyl bromide unit and a protected amine functional group. The use of CuBr / N,N,N′,N′′,N′′-pentamethyldiethylenetriamine (PMDETA) as co-catalyst system results in a polymer free of halogen due to hydrogen transfer from PMDETA to the growing polymer chain. However, side reactions occur affecting the typically “living” character of the ATRP. The measured molecular weights are consistently higher than the theoretical ones and the molecular weight distributions are relatively broad. 相似文献
810.