Reporting of variations in the natural isotopic composition of mercury

High-precision measurements of natural variations in the stable isotopic composition of mercury show great promise as a new tracer of mercury sources and chemical transformations in the environment. We strongly suggest that all laboratories adopt a common means of data correction, standardization, and nomenclature in order to ensure that data from various laboratories can be easily evaluated and compared. We make suggestions for mass bias correction, reporting of mass-dependent and mass-independent isotope variations, and a standard protocol for reporting analytical uncertainties. We also present our measured values for isotope ratios in several mercury standard solutions.     

Optimization of a novel headspace–solid‐phase microextraction–gas chromatographic method by means of a Doehlert uniform shell design for the analysis of trace level ethylene oxide residuals in sterilized medical devices

Medical devices sterilized by ethylene oxide (EtO) retain trace quantities of EtO residuals, which may irritate patients' tissue. Reliably quantifying trace level EtO residuals in small medical devices requires an extremely sensitive analytical method. In this research, a Doehlert uniform shell design was utilized in obtaining a response surface to optimize a novel headspace–solid‐phase microextraction–gas chromatographic (HS‐SPME‐GC) method developed for analyzing trace levels of EtO residuals in sterilized medical devices, by evaluating sterilized, polymer‐coated, drug‐eluting cardiovascular stents. The effects of four independent experimental variables (HS‐SPME desorption time, extraction temperature, GC inlet temperature and extraction time) on GC peak area response of EtO were investigated simultaneously and the most influential experimental variables determined were extraction temperature and GC inlet temperature, with the fitted model showing no evidence of lack‐of‐fit. The optimized HS‐SPME‐GC method demonstrated overall good linearity/linear range, accuracy, repeatability, reproducibility, absolute recovery and high sensitivity. This novel method was successfully applied to analysis of trace levels of EtO residuals in sterilized/aerated cardiovascular stents of various lengths and internal diameter, where, upon heating, trace EtO residuals fully volatilized into HS for extraction, thereby nullifying matrix effects. As an alternative, this novel HS‐SPME‐GC method can offer higher sensitivity compared with conventional headspace analyzer‐based sampling. Copyright © 2009 John Wiley & Sons, Ltd.     

Monogamous latin squares

We show for all n∉{1,2,4} that there exists a latin square of order n that contains two entries γ₁ and γ₂ such that there are some transversals through γ₁ but they all include γ₂ as well. We use this result to show that if n>6 and n is not of the form 2p for a prime p?11 then there exists a latin square of order n that possesses an orthogonal mate but is not in any triple of MOLS. Such examples provide pairs of 2-maxMOLS.     

Children's perceptions of their acoustic environment at school and at home

This paper describes the results of a large-scale questionnaire survey that ascertained children's perceptions of their noise environment and the relationships of the children's perceptions to objective measures of noise. Precision, specificity, and consistency of responding was established through the use of convergent measures. Two thousand and thirty-six children completed a questionnaire designed to tap (a) their ability to discriminate different classroom listening conditions; (b) the noise sources heard at home and at school; and (c) their annoyance by these noise sources. Teachers completed a questionnaire about the classroom noise sources. Children were able to discriminate between situations with varying amounts and types of noise. A hierarchy of annoying sound sources for the children was established. External L(Amax) levels were a significant factor in reported annoyance, whereas external L(A90) and L(A99) levels were a significant factor in determining whether or not children hear sound sources. Objective noise measures (L(A90) and L(A99)) accounted for 45% of the variance in children's reporting of sounds in their school environment. The current study demonstrates that children can be sensitive judges of their noise environments and that the impact of different aspects of noise needs to be considered. Future work will need to specify the factors underlying the developmental changes and the physical and location dimensions that determine the school effects.     

A homologous series of eunicellin-based diterpenes from Acalycigorgia sp. characterised by tandem mass spectrometry

The discovery and structure determination of a homologous series of eunicellin-based diterpenes from the gorgonian Acalycigorgia sp. is described. Extensive use was made of 1D and 2D NMR data to determine the structure of the diterpene skeleton. The relative stereochemistry was confirmed via the use of NOE data in conjunction with molecular modelling. A series of homologues were identified using a combination of product and precursor ion scanning modes in tandem mass spectrometry. This powerful technique afforded excellent clarification to aid the analysis of the complex mass spectral data.     

Enantioselectivity and cis/trans-Selectivity in Dirhodium(II)-Catalyzed addition of diazoacetates to olefins

The Rh¹¹-catalyzed carbenoid addition of diazoacetates to olefins was investigated with [Rh₂{(4S)-phox}₄] ( 1 ;phox = tetrakis[(4S)-tetrahydro-4-phenyloxazol-2-one]), [Rh₂{(2S)-mepy}₄] ( 2 ; mepy = tetrakis[methyl (2S)-tetrahydro-5-oxopyrrole-2-carboxylate]), and [Rh₂(OAc)₄] ( 3 ). While catalysis with 2 and 3 afford preferentially trans-cyclopropanecarboxylates, the cis-isomers are the major products with 1 . In general, the enantioselectivities achieved with 1 and 2 are comparable. Additions catalyzed by 1 are strongly sensitive to steric effects. Highly substituted olefins afford cyclopropanes in only poor yield. The preferential cis-selectivity observed in reactions catalyzed by 1 is attributed to dominant interactions between the ligand of the catalyst and the substituents of both olefin and diazoacetate, which overrule the steric interactions between olefin and diazoacetate in the transition state for carbene transfer.