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91.
Josic D Breen L Clifton J Gajdosik MS Gaso-Sokac D Rucevic M Müller E 《Electrophoresis》2012,33(12):1842-1849
Sample displacement chromatography (SDC) in reversed-phase and ion-exchange modes was introduced approximately 20 years ago. This method was first used for the preparative purification of peptides and proteins. Recently, SDC in ion-exchange mode was also successfully used for enrichment of low-abundance proteins from human plasma. In this paper, the use of SDC for the separation of plasma proteins in hydrophobic interaction mode is demonstrated. By use of two or more columns coupled in series during sample application, and subsequent elution of detached columns in parallel, additional separation of bound proteins was achieved. Further low-abundance, physiologically active proteins could be highly enriched and detected by ESI-MS/MS. 相似文献
92.
Marilyn Breen 《Aequationes Mathematicae》2014,87(1-2):43-52
Let S be an orthogonal polytope in ${\mathbb{R}^d}$ . There exists a suitable family ${\mathcal{C}}$ of boxes with ${S = \cup \{C : C {\rm in} \mathcal{C}\}}$ such that the following properties hold: The staircase kernel Ker S is a union of boxes in ${\mathcal{C}}$ . Let ${\mathcal{V}}$ be the family of vertices of boxes in ${\mathcal{C}}$ , and let ${v_o\, \epsilon \mathcal{V}}$ . Point v o belongs to Ker S if and only if v o sees via staircase paths in S every point w in ${\mathcal{V}}$ . Moreover, these staircase paths may be selected to consist of edges of boxes in ${\mathcal{C}}$ . Let B be a box in ${\mathcal{C}}$ with vertices of B in Ker S. Box B lies in Ker S if and only if, for some b in rel int B and for every translate H of a coordinate hyperplane at ${b, b \epsilon}$ Ker (H ∩ S). For point p in S, p belongs to Ker S if and only if, for every x in S, there exist some p ? x geodesic λ (p, x) and some corresponding ${\mathcal{C}}$ - chain D containing λ (p, x) such that D is staircase starshaped at p. 相似文献
93.
Marilyn Breen 《Aequationes Mathematicae》2012,84(3):207-217
Let ${\mathcal{K}}$ be a family of simply connected sets in the plane. If every countable subfamily of ${\mathcal{K}}$ has an intersection that is starshaped via orthogonally convex paths, then ${\mathcal{K}}$ itself has such an intersection. For the d-dimensional case, let ${\mathcal{K}}$ be a family of compact sets in ${\mathbb{R}^d}$ . If every finite subfamily of ${\mathcal{K}}$ has an intersection that is starshaped via orthogonally convex paths, again ${\mathcal{K}}$ itself has such an intersection. 相似文献
94.
No Abstract.
February 8, 1999 相似文献
95.
96.
Substrate Activity Screening with Kinases: Discovery of Small‐Molecule Substrate‐Competitive c‐Src Inhibitors
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Meghan E. Breen Michael E. Steffey Eric J. Lachacz Frank E. Kwarcinski Christel C. Fox Prof. Matthew B. Soellner 《Angewandte Chemie (International ed. in English)》2014,53(27):7010-7013
Substrate‐competitive kinase inhibitors represent a promising class of kinase inhibitors, however, there is no methodology to selectively identify this type of inhibitor. Substrate activity screening was applied to tyrosine kinases. By using this methodology, the first small‐molecule substrates for any protein kinase were discovered, as well as the first substrate‐competitive inhibitors of c‐Src with activity in both biochemical and cellular assays. Characterization of the lead inhibitor demonstrates that substrate‐competitive kinase inhibitors possess unique properties, including cellular efficacy that matches biochemical potency and synergy with ATP‐competitive inhibitors. 相似文献
97.
Marilyn Breen 《Monatshefte für Mathematik》2003,139(2):105-109
Let S be a nonempty closed, simply connected set in the plane. For α > 0, let ℳ denote the family of all maximal subsets of S which are starshaped via paths of length at most α. Then ⋂{M : M in ℳ} is either starshaped via α-paths or empty. The result fails without the simple connectedness condition. However, even
with a simple connectedness requirement, there is no Helly theorem for intersections of sets which are starshaped via α-paths.
Received November 19, 2001; in revised form April 25, 2002
Published online November 18, 2002 相似文献
98.
Aidan Breen Vladimir Milosavljević Denis P. Dowling 《Plasma Chemistry and Plasma Processing》2011,31(5):771-785
Microwave plasmas have enormous potential as a rapid and energy efficient sintering technology. This paper evaluates the influence
of both plasma atmosphere and metal powder type on the sintering temperatures achieved and the properties of the sintered
powder metal compacts. The sintering is carried out using a 2.45 GHz microwave-plasma process called rapid discharge sintering
(RDS). The sintering of three types of metal powder are evaluated in this study: nickel (Ni), copper (Cu) and 316L stainless
steel (SS). An in-depth study of the effects of the plasma processing parameters on the sintered powder compacts are investigated.
These parameters are correlated with the mechanical performance of the sintered compacts to help understand the effect of
the plasma heating process. The substrate materials are sintered in four different gas discharges, namely hydrogen, nitrogen
oxygen and argon. Thermocouple, pyrometer and emission spectroscopy measurements were taken to determine the substrate and
the discharge temperatures. The morphology and structure were examined using scanning electron microscopy and X-ray diffraction.
The density and hardness of the sintered compacts were correlated with the plasma processing conditions. As expected higher
densities were obtained with powders with lower sintering temperatures i.e. nickel and copper when compared with stainless
steel. Under the power input and pressure conditions used, the highest substrate temperature attained was 1,100°C for Cu powder
sintered in a nitrogen atmosphere. In contrast under the same processing conditions but in an argon plasma, the temperature
achieved with SS was only 500°C. The effect of the plasma gas type on the sintered powder compact chemistry was also monitored,
both hydrogen and nitrogen yielded a reducing effect for the metal in contrast with the oxidising effect observed in an oxygen
plasma. 相似文献
99.
İlknur Tatlıdil Münevver Sökmen Chris Breen Francis Clegg Celal Kurtuluş Buruk Emin Bacaksız 《Journal of Sol-Gel Science and Technology》2011,60(1):23-32
In this study, both suspensions and thin films of TiO2 and silver loaded TiO2 (Ag-TiO2) were used in the photocatalytic degradation/disinfection of C. albicans. In the case of thin films coated materials, both microscope slides and steel pieces of similar dimensions were dip coated
using sol–gel solutions prepared from titanium isopropoxide. Surface analysis of the materials confirmed that thin film formation
had been succesful. After set periods of irradiation in the presence of suspension or thin film coated material, 10 μL aliquots
of the solution were withdrawn and directly cultivated on sabouraud dextrose agar for 24 h at 37 °C. The number of living
colonies was counted. The results show that both the suspensions and the thin films displayed superior antimicrobial properties
towards C. albicans. In particular the Ag-TiO2 catalyst was extremely active even in the dark, for disinfection of C. albicans. The degradation percentage over TiO2 and Ag-TiO2 thin films coated on the steel substrate was higher than those coated on glass achieving 80 and 97.9%, respectively, using
the 365 nm, near visible region light source. 相似文献
100.
Colum Breen Robert Pal Mark R. J. Elsegood Simon J. Teat Felipe Iza Kristian Wende Benjamin R. Buckley Stephen J. Butler 《Chemical science》2020,11(12):3164
Peroxynitrite (ONOO−) is a powerful and short-lived oxidant formed in vivo, which can react with most biomolecules directly. To fully understand the roles of ONOO− in cell biology, improved methods for the selective detection and real-time analysis of ONOO− are needed. We present a water-soluble, luminescent europium(iii) probe for the rapid and sensitive detection of peroxynitrite in human serum, living cells and biological matrices. We have utilised the long luminescence lifetime of the probe to measure ONOO− in a time-resolved manner, effectively avoiding the influence of autofluorescence in biological samples. To demonstrate the utility of the Eu(iii) probe, we monitored the production of ONOO− in different cell lines, following treatment with a cold atmospheric plasma device commonly used in the clinic for skin wound treatment.Reactivity-based europium(iii) probe displays excellent selectivity for peroxynitrite (ONOO−), enabling its time-resolved luminescence detection in living cells. 相似文献