排序方式: 共有26条查询结果,搜索用时 250 毫秒
21.
Emma E. Blackham Prof. Dr. Kevin I. Booker-Milburn 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(23):6713-6716
A short, 5-step total synthesis of (±)-3-demethoxyerythratidinone from a simple pyrrole derivative is described. Features include the formation of gram quantities of a key tricylic aziridine from a challenging photochemical cascade reaction through the use of flow photochemistry. The final step involved a highly unusual Heck cyclization whereby ligand control enabled efficient formation of the natural product in 69 % yield from the minor isomer present in an equilibrating mixture of labile enamines. 相似文献
22.
Houlden CE Bailey CD Ford JG Gagné MR Lloyd-Jones GC Booker-Milburn KI 《Journal of the American Chemical Society》2008,130(31):10066-10067
A Pd-catalyzed intermolecular 1,2-carboamination route to indolines from N-aryl ureas and 1,3-dienes that proceeds under mild conditions in relatively nonacidic media, is presented. The in situ generation, or preformation, of a palladium tosylate emerges as a key parameter in gaining the requisite reactivity for the C-H insertion/carbopalladation/nucleophilic displacement process. 相似文献
23.
Complex aza-fuzed tricyclic lactones are obtained in a two-step photochemical cycloaddition/acid-catalyzed rearrangement of simple alkoxy maleimide derivatives. The sequence involves a complex acid-catalyzed skeletal rearrangement of the intermediate alkylideneoxetanols. 相似文献
24.
Hook BD Dohle W Hirst PR Pickworth M Berry MB Booker-Milburn KI 《The Journal of organic chemistry》2005,70(19):7558-7564
[reaction: see text] Compact flow reactors have been constructed and optimized to perform continuous organic photochemistry on a large scale. The reactors were constructed from commercially available or customized immersion well equipment combined with UV-transparent, solvent-resistant fluoropolymer (FEP) tubing. The reactors were assessed using the [2 + 2] photocycloaddition of malemide 1 and 1-hexyne forming the cyclobutene product 2 and the intramolecular [5 + 2] photocycloaddition of 3,4-dimethyl-1-pent-4-enylpyrrole-2,5-dione 3 to form the bicyclic azepine 4. The reactors were shown to be capable of producing >500 g of 2 and 175 g of 4 in a continuous 24 h processing period. Due to the facile control of irradiation time, the continuous flow reactor was also shown to be superior to a batch reactor for performing a problematic photochemical reaction on a larger scale. 相似文献
25.
Anson CE Bibb MJ Booker-Milburn KI Clissold C Haley PJ Hopwood DA Ichinose K Revill WP Stephenson GR Surti CM 《Angewandte Chemie (International ed. in English)》2000,39(1):224-227
Potential "reagents" for the enantioselective reduction, and other biotransformations, of beta-keto-esters result from the genetic engineering of Streptomyces coelicolor A3(2). For example, incubation of the N-acetylcysteamine thioester 1 with the recombinant strain CH999/pIJ5675 followed by treatment with MeOH/HCl gave the lactone 2 as essentially a single enantiomer. 相似文献
26.
Elliott LD Wrigglesworth JW Cox B Lloyd-Jones GC Booker-Milburn KI 《Organic letters》2011,13(4):728-731
N-Ts and N-Boc derivatives of 1,2-diamines and 1,2-amino alcohols are shown to undergo efficient Pd(II)-catalyzed aza-Wacker reactions with a large range of electron-deficient alkenes. The resulting enamine intermediate generally undergoes cyclization with the second heteroatom to form 1,3-heterocycles. The sequence facilitates the rapid synthesis of saturated oxazolidines, imidazolidines, and their derivatives. Use of N-L-valinol derivatives results in highly diastereoselective reactions, where the net stereochemical outcome diverges between N-Ts and N-Boc. 相似文献