Temperaturabhängigkeit der Gleichgewichtsspreitungsdrucke homologer Lezithine an der Grenzfläche n-Heptan/0,1 M NaCl

Ohne ZusammenfassungMit 1 Abbildung und 1 Tabelle     

Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR

Opportunistic pathogens exploit diverse strategies to sabotage host defenses. Pseudomonas aeruginosa secretes the CFTR inhibitory factor Cif and thus triggers loss of CFTR, an ion channel required for airway mucociliary defense. However, the mechanism of action of Cif has remained unclear. It catalyzes epoxide hydrolysis, but there is no known role for natural epoxides in CFTR regulation. It was demonstrated that the hydrolase activity of Cif is strictly required for its effects on CFTR. A small‐molecule inhibitor that protects this key component of the mucociliary defense system was also uncovered. These results provide a basis for targeting the distinctive virulence chemistry of Cif and suggest an unanticipated role of physiological epoxides in intracellular protein trafficking.     

Wetting of InP by indium- and indium-tin melts

Orientation dependent wetting of InP substrates by In- and In_xSn_1−x melts saturated with InP was studied using the sessile drop method. The contact angle was found to depend on the substrate orientation as follows: It is shown that a tin admixture to the indium melt improves the wetting behaviour. Additional to the dependence on substrate orientation it was found an anisotropic wetting on all investigated faces.