8-Amino-6-Methoxyquinoline—Tetrazole Hybrids: Impact of Linkers on Antiplasmodial Activity

A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and the tert-butyltetrazole moieties differ in chain length, basicity and substitution. Compounds were tested for their antiplasmodial activity against Plasmodium falciparum NF54 as well as their cytotoxicity against L-6-cells. The activity and the cytotoxicity were strongly influenced by the linker and its substitution. The most active compounds showed good activity and promising selectivity.     

The Sedimentation of Colloidal Nanoparticles in Solution and Its Study Using Quantitative Digital Photography

Sedimentation and diffusion are important aspects of the behavior of colloidal nanoparticles in solution, and merit attention during the synthesis, characterization, and application of nanoparticles. Here, the sedimentation of nanoparticles is studied quantitatively using digital photography and a simple model based on the Mason–Weaver equation. Good agreement between experimental time‐lapse photography and numerical solutions of the model is found for a series of gold nanoparticles. The new method is extended to study for the first time the gravitational sedimentation of DNA‐linked gold nanoparticle dimers as a model system of a higher complexity structure. Additionally, simple formulas are derived for estimating suitable parameters for the preparative centrifugation of nanoparticle solutions.     

Der Nachweis von Flavanonen und Flavanonolen

Ohne Zusammenfassung     

Zur Trennung von Molkenproteinen

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Zum qualitativen Nachweis von Stickstoff im Rahmen der C-H-Bestimmung

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Den papierchromatographischen Nachweis grenzfl?chenaktiver Stoffe

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Collective excitations in148Gd populated in thep p′-reaction on a radioactive target

Collective excitations in the two-particle nucleus¹⁴⁸Gd up to 2.9 MeV have been investigated by thepp′-reaction at 25 MeV beam energy, and angular distributions have been analyzed with standard DWBA calculations. It is found that¹⁴⁸Gd has larger octupole- than quadrupole collectivity in the energy range investigated. The 3^? strength distribution is in quantitative agreement with predicted results for the levels formed by the coupling of two valence particles to the¹⁴⁶Gd core octupole phonon.