A quantitative study of sodium tungstate protective effect on pancreatic beta cells in streptozotocin-induced diabetic rats

Diabetes is a major public health problem. Development of new therapies that are able to improve glycemia management, cure diabetes, and can even protect from it, are of great interest. This study investigated the protective effect of sodium tungstate against STZ-induced beta-cell damages by means of stereological methods. Sixty rats were divided into six groups: control (C), tungstate-treated control (TC), STZ-induced diabetic (D), STZ-induced diabetic rats were treated by sodium tungstate from 1 week before STZ injection (TDB), food-restricted diabetic (FRD), and diabetic rats treated with sodium tungstate 1 week after STZ administration (TDA). Stereological estimation of pancreas volume, islets volume density, volume-weighted mean islets volume and mass of beta cells, islets, and pancreas and total number of islets were done. Islets volume density, volume-weighted mean islets volume, and mass of beta cells, islets, and pancreas of TDB group was significantly higher than D, FRD and TDA groups (P < 0.001) and was comparable to controls (C and TC groups). Total number of islets, pancreas wet weight and volume did not show any significant changes between these groups (P > 0.05).Results suggested that sodium tungstate preserves pancreatic beta cells from STZ-induced damages and diabetes induction in rats.     

A Novel Fluorescence Nanobiosensor based on Modified Graphene Quantum dots-HTAB for Early Detection of Fetal Sexuality with Cell Free Fetal DNA

Journal of Fluorescence - Recently, prenatal diagnosis with non-invasive insight is a progressive approach in clinical medicine to prevent the birth of infants with genetic abnormalities. Cell free...     

Synthesis of arylidenepyruvic amide derivatives via Ugi-four component condensation

Arylidenepyruvic acids (APAs) have been successfully employed in an Ugi-four component condensation reaction which yielded polyfunctional amides. Condensation of various APAs, aldehydes, amines, and isocyanides at room temperature in 96% ethanol as a green solvent proceeded in good yields. The extension of the reaction to diamines, formaldehyde, and isocyanides to form more complex molecules is also reported. These novel products may have potential in various pharmaceutical applications.     

A novel three-component reaction for the synthesis of N-cyclohexyl-3-aryl-quinoxaline-2-amines

Ferric perchlorate catalyzes the three-component condensation reaction of o-phenylenediamine, aromatic aldehydes, and cyclohexyl isocyanide to afford the corresponding N-cyclohexyl-3-aryl-quinoxaline-2-amines in good yields.     

Three-Component Synthesis of Dialkyl 2-(Alkylimino-Methylene)3- (2,2,5-Trimethyl-4,6-Dioxo-1,3-Dioxan-5-Yl)-Succinates

The adduct produced in the reaction between alkyl isocyanides and dialkyl acetylenedicarboxylates was trapped by 2,2,5-trimethyl-1,3-dioxane-4,6-dione (methyl Meldrum's acid), to afford highly functionalized ketenimines in good yields.