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11.
A simple, accurate, and sensitive spectrophotometric method for the determination of promethazine hydrochloride (PMH), prochlorperazine
maleate (PCPM), trifluoperazine hydrochloride (TFPH), trimeperazine tartrate (TMT), fluphenazine dihydrochloride (FH), and
trifluopromazine hydrochloride (TPH) is described. The method is based on the oxidation of the studied drugs by a known excess
of chloramine-T in a hydrochloric acid medium and subsequent determination of the unreacted oxidant by interacting it with
iodide in the same acid medium. Liberated iodine subsequently reacts with starch to form a stable starch-iodine complex. The
reacted oxidant corresponds to the drug content. The colored complex exhibits a maximum absorption at 590 nm. The apparent
molar absorptivity and Sandell sensitivity values are in the range 4.07 × 104 − 1.18 × 105 L/mol cm and 45.00−95.00 ng/cm2, respectively. The proposed method has been applied to the assay of phenothiazine drugs in pure and dosage forms. The reliability
of the analysis was established using parallel determination by the reference method.
The text was submitted by the authors in English. 相似文献
12.
Okram Zenita Devi Kanakapura Basavaiah H. D. Revanasiddappa Kanakapura Basavaiah Vinay 《Journal of Analytical Chemistry》2011,66(5):490-495
Titrimetric and spectrophotometric assay of pantoprazole sodium sesquihydrate (PSS) using cerium(IV) sulphate as the oxidimetric reagent is described. The methods are based on the oxidation of PSS with a
measured excess of Ce(IV) sulphate followed by the determination of unreacted oxidant using different reaction schemes. In
titrimetry, the unreacted oxidant was determined by back titration with ferrous ammonium sulphate (FAS) in sulphuric acid medium. Spectrophotometry involves the reduction of unreacted Ce(IV) sulphate with a fixed quantity of
Fe(II). The resulting Fe(III) is complexed with thiocyanate and the absorbance is measured at 470 nm. In both the methods,
the amount of Ce(lV) sulphate reacted corresponds to PSS concentration. Titrimetry is applicable over 1–10 mg range whereas
in spectrophotometry, the calibration graph is linear in the range of 0.5–7.0 μg/mL and the calculated molar absorptivity
value is 1.58 × 105 L/mol cm. The validity of the proposed methods was tested by analyzing pure and dosage forms containing PSS. Statistical
treatment of the results reflects that the proposed procedures are precise, accurate and easily applicable to the determination
of PSS in pure form and in pharmaceutical formulations. 相似文献
13.
A simple, rapid, and sensitive spectrophotometric method has been developed for the determination of selenium in real samples of water, soil, plant materials, human hair, and synthetic cosmetic and in pharmaceutical preparations. The method is based on the reaction of selenium with potassium iodide in an acidic medium to liberate iodine. The liberated iodine bleaches the violet color of thionin, and which is measured at 600 nm. This decrease in absorbance is directly proportional to selenium concentration and obeys Beer's law in the range 1-5 micro g selenium in a final volume of 10 mL (0.1-0.5 microg mL(-1)). The molar absorptivity and Sandell's sensitivity of the method were found to be 7.33 x 10(4) L mol(-1) cm(-1) and 0.0011 microg cm(-2), respectively. The optimum reaction conditions and other analytical conditions were evaluated. The effect of interfering ions on the determination is described. 相似文献
14.
K.M. Prabhu Kumar B.C. Vasantha Kumar P. Raghavendra Kumar Ray J. Butcher H.K. Vivek P.A. Suchetan H.D. Revanasiddappa Sabine Foro 《应用有机金属化学》2020,34(6):e5634
A novel selenated Schiff base (S) -L 1 H has been synthesized from (2S)-1-(benzylselanyl)-3-phenylpropan-2-amine which upon reduction formed a reduced Schiff base (S) -L 2 H . Palladium (II) complexes (S) -1 and (S) -2 of ligands (S) -L 1 H and (S) -L 2 H respectively were successfully synthesized. The structures of all four compounds were thoroughly identified by analytical and various spectroscopic techniques. The absolute molecular structures of the above two complexes were further confirmed by single crystal X-ray diffraction. Both (S) -L 1 H and (S) -L 2 H coordinated as monobasic ((S) -L 1–2 ), chelating, tridentate (Se,N,O−) ligands resulting in the complexes of composition (S) - [PdCl( L 1/2 )] [(S) -1/2 ]. In the crystals of complexes (S) -1 and (S) -2 , there were moderate to strong Se⋯O, CH⋯Cl and CH⋯O types of intermolecular secondary interactions. CT-DNA binding activity of these selenium-containing ligands and their palladium complexes bearing a Pd–Se bond have been evaluated for the first time by performing electronic absorption titration and fluorescence emission quenching using CT-DNA-EB and viscometric experiments. These ligands and complexes exhibited remarkable DNA binding activity as shown by their intrinsic DNA binding constants (Kb) and Stern–Volmer constants (Ksv) in the ranges 5.2–9.9 × 104 and 3.6–4.7 × 104, respectively. The viscosity of CT-DNA decreases with increasing concentration of these compounds. The results of the DNA-binding studies revealed that all of the compounds interact with DNA at a minor groove which was further confirmed by molecular docking studies. 相似文献
15.
A new, simple, highly sensitive and rapid spectrophotometric method has been described for the determination of platinum(IV). The method is based on the oxidation of leuco xylene cyanol FF (LXCFF) to its blue form of xylene cyanol FF by platinum(IV) in sulfuric acid medium (pH 1.0-2.5), the formed dye shows an absorption maximum at 620 nm in acetate buffer medium (pH 3.0-4.5). The method obeys Beer's law over a concentration range of 0.3 to 2.6 micro g mL(-1) platinum, having molar absorptivity and Sandell's sensitivity of 5.1x10(4) L mol(-)(1) cm(-1) and 0.0038 micro g cm(-2), respectively. The optimum reaction conditions and other analytical parameters have been evaluated. The developed method has been successfully applied to the determination of platinum in pharmaceutical preparations, soil, natural water, plant material, platinum-containing catalyst, and synthetic alloy samples. 相似文献
16.
A simple, rapid, and accurate HPLC method is described for the determination of ritodrine hydrochloride (RTH) in both pure form and pharmaceutical formulations. A Hypersil Shendon ODS column with a mobile phase of dibasic phosphate buffer and acetonitrile (75 : 25) and isoxsuprine hydrochloride were used as an internal standard. The flow rate was 1 mL min–1 and the effluent was monitored at 270 nm pH 4.0. The calibration graph is linear in the range 2–30 g mL–1. The proposed HPLC method has been successfully employed for the determination of RTH in Yutopar tablets and injection solutions. 相似文献
17.
Bhat Mahima Gurubasavaraja Swamy P. M. Poojary Boja Revanasiddappa B. C. Vijay Kumar M. Kumar Vasantha 《Research on Chemical Intermediates》2018,44(4):2779-2805
Research on Chemical Intermediates - A new series of hybridized thiazol-2-yl-hydrazone derivatives having diverse substituents were designed, synthesized, and screened for their anti-inflammatory... 相似文献
18.
A Facile Spectrophotometric Determination of Nitrite Using Diazotization with p-Nitroaniline and Coupling with Acetyl Acetone 总被引:4,自引:0,他引:4
A simple and sensitive spectrophotometric method is described for the determination of nitrite in water and soil samples.
The method is based on the reaction of nitrite with p-nitroaniline to form a diazonium ion, which is coupled with a new coupling
agent, acetyl acetone in an alkaline medium. The dye shows an absorption maximum at 490 nm and obeys Beer’s law over a range
of 0.5 to 14 μg nitrite per 10 mL analyte. The molar absorptivity of the colour system is 3.2×104 L mol−1 cm−1. The relative standard deviation is 2.7% (n = 10). The dye formed is stable for 3 h. The effect of interfering ions on the
determination is described. The method has been suggested for the determination of nitrite in water and soil samples. The
results obtained were compared with the standard N-(1-naphthyl) ethylenediamine dihydrochloride method.
Received April 12, 2001. 相似文献
19.
Hosakere D. Revanasiddappa Banadahalli P. Dayananda 《Central European Journal of Chemistry》2006,4(4):592-603
Highly sensitive and simple spectrophotometric determination of selenium is described for the determination of selenium(IV)
using a new reagent leuco malachite green. The method is based on the reaction of selenium(IV) with potassium iodide in an
acidic condition to liberate iodine, the liberated iodine oxidizes leuco malachite green to malachite green dye. The green
coloration was developed in an acetate buffer (pH 4.2–4.9) on heating in a water bath (∼ 40 °C). The formed dye exhibits an
absorption maximum at 615 nm. The method obeys Beer’s law over a concentration range of 0.04–0.4 μg mL−1 selenium. The molar absorptivity and Sandell’s sensitivity of the color system were found to be 1.67 × 105 L mol−1 cm-1 and 0.5 ng cm−2, respectively. The optimum reaction conditions and other analytical parameters have been evaluated. The proposed procedure
has been successfully applied to the determination of selenium in real samples of water, soil, plant material, human hair,
and cosmetic samples. The results were compared to those obtained with the reference method. Statistical analysis of the results
confirms the precision and accuracy of the proposed method. In addition, the developed method is cost-effective and involves
easily accessible instrumentation technique which can be used by ordinary research laboratories. 相似文献
20.
Journal of Applied Spectroscopy - Elimination and distribution of drugs are affected by human serum albumin (HSA) interaction. In children and adults, specific types of seizures are controlled by... 相似文献