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排序方式: 共有215条查询结果,搜索用时 62 毫秒
71.
Arianna Actis Prof. Dr. Michele Melchionna Dr. Giacomo Filippini Prof. Dr. Paolo Fornasiero Prof. Dr. Maurizio Prato Prof. Dr. Mario Chiesa Prof. Dr. Enrico Salvadori 《Angewandte Chemie (International ed. in English)》2023,62(48):e202313540
Time-resolved EPR (TR-EPR) demonstrates the formation of well-defined spin triplet excitons in carbon nitride. This permits to experimentally probe the extent of the triplet wavefunction which delocalizes over several tri-s-triazine units. Analysis of the temperature dependence of the TR-EPR signal reveals the mobility of the triplet excitons. By employing monochromatic light excitation in the range 430–600 nm, the energy of the spin triplet is estimated to be ≈0.2 eV above the conduction band edge, proving that the triplet exciton lies above the corresponding singlet. Comparison between amorphous and graphitic forms establishes the singlet-triplet inversion as a general feature of carbon nitride materials. 相似文献
72.
Arianna Melillo Rocio García-Aboal Dr. Sergio Navalón Dr. Pedro Atienzar Dr. Belén Ferrer Prof. Dr. Mercedes Álvaro Prof. Dr. Hermenegildo García 《Chemphyschem》2021,22(9):842-848
Solid-state photovoltaic cells based on robust metal-organic frameworks (MOFs), MIL-125(Ti), MIL-125(Ti)-NH2, UiO-67, Ru(bpy)2-UiO-67, (bpy 2,2‘-bipyridine) as active components and spiro-MeOTAD (MeOTAD 2,2‘,7,7‘-tetrakis[N,N-di(p-methoxyphenyl)amino]-9,9′-spirobifluorene) as hole transporting layer have been prepared., The photovoltaic response of this material increases in the presence of bathochromic −NH2 groups on the linker or Ru (II) polypyridyl complexes light harvester. These results show that the strategies typically employed in photocatalysis to enhance the photocatalytic activity of MOFs can also be applied in the field of photovoltaic devices. 相似文献
73.
Joseph?G.?Conlon Arianna?GiuntiEmail author Felix?Otto 《Calculus of Variations and Partial Differential Equations》2017,56(6):163
This paper is divided into two parts: In the main deterministic part, we prove that for an open domain \(D \subset \mathbb {R}^d\) with \(d \ge 2\), for every (measurable) uniformly elliptic tensor field a and for almost every point \(y \in D\), there exists a unique Green’s function centred in y associated to the vectorial operator \(-\nabla \cdot a\nabla \) in D. This result implies the existence of the fundamental solution for elliptic systems when \(d>2\), i.e. the Green function for \(-\nabla \cdot a\nabla \) in \(\mathbb {R}^d\). In the second part, we introduce a shift-invariant ensemble \(\langle \cdot \rangle \) over the set of uniformly elliptic tensor fields, and infer for the fundamental solution G some pointwise bounds for \(\langle |G(\cdot ; x,y)|\rangle \), \(\langle |\nabla _x G(\cdot ; x,y)|\rangle \) and \(\langle |\nabla _x\nabla _y G(\cdot ; x,y)|\rangle \). These estimates scale optimally in space and provide a generalisation to systems of the bounds obtained by Delmotte and Deuschel for the scalar case. 相似文献
74.
Highly Stereoselective [4+2] and [3+2] Spiroannulations of 2‐(2‐Oxoindolin‐3‐ylidene)acetic Esters Catalyzed by Bifunctional Thioureas
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Prof. Magda Monari Dr. Elisa Montroni Andrea Nitti Prof. Marco Lombardo Prof. Claudio Trombini Dr. Arianna Quintavalla 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(31):11038-11049
A new Michael–Michael cascade reaction between 2‐(2‐oxoindolin‐3‐ylidene)acetic esters 1 and nitroenoates 2 , catalyzed by bifunctional thioureas, is investigated. The combination of the two Michael reactions results in a novel and facile [4+2] or [3+2] spiroannulation process, which is characterized by the following features: 1) two carbon–carbon bonds and four stereocenters, including a quaternary spiro carbon, are formed under mild conditions; 2) an unprecedented and stereochemically defined substitution pattern on the spirocarbocyclic unit is obtained; 3) the double‐bond configuration of the donor–acceptor nitroenoate 2 determines the absolute configuration of the spiro center, whereas the remaining stereocenters are formed under control of the catalyst. The effect on the final stereochemical outcome of structural variations of each starting material, catalyst, and experimental conditions is analyzed in detail. In particular, the use of specifically designed chiral nitroenoates enables diverse polyfunctional spirocyclohexane derivatives containing six consecutive stereogenic centers to be constructed. To our knowledge, this is the first asymmetric organocatalytic strategy enabling both five‐ and six‐membered β‐nitro spirocarbocyclic oxindoles. 相似文献
75.
Prof. Dr. Wolfgang Scherer Dr. Andrew C. Dunbar Dr. José E. Barquera‐Lozada Dominik Schmitz Dr. Georg Eickerling Dr. Daniel Kratzert Prof. Dr. Dietmar Stalke Arianna Lanza Dr. Piero Macchi Dr. Nicola P. M. Casati Dr. Jihaan Ebad‐Allah Prof. Dr. Christine Kuntscher 《Angewandte Chemie (International ed. in English)》2015,54(8):2505-2509
Square‐planar d8‐ML4 complexes might display subtle but noticeable local Lewis acidic sites in axial direction in the valence shell of the metal atom. These sites of local charge depletion provide the electronic prerequisites to establish weakly attractive 3c–2e M???H? C agostic interactions, in contrast to earlier assumptions. Furthermore, we show that the use of the sign of the 1H NMR shifts as major criterion to classify M???H? C interactions as attractive (agostic) or repulsive (anagostic) can be dubious. We therefore suggest a new characterization method to probe the response of these M???H? C interactions under pressure by combined high pressure IR and diffraction studies. 相似文献
76.
Rosi F Federici A Brunetti BG Sgamellotti A Clementi S Miliani C 《Analytical and bioanalytical chemistry》2011,399(9):3133-3145
Paintings are composed of superimposed layers of inorganic and organic materials (pigments and binders). Knowledge of the
stratigraphic sequence of these heterogeneous layers is fundamental for understanding the artist’s painting technique and
for conservation issues. In this study, micro-IR mapping experiments in reflection mode have been carried out on cross-sections
taken from simulations of ancient easel paintings. The objective was to locate both organic binders and inorganic pigments.
Chemical maps have been re-constructed using the common approach based on the integration of specific infrared bands. However,
owing to the complexity of painting materials, this approach is not always applicable when dealing with broad and superimposed
spectral features and with reststrahlen or derivative-like bands resulting from acquisition in reflection mode. To overcome these limitations, principal-component
analysis has been successfully used for the re-construction of the image, extracting the relevant information from the complex
full spectral data sets and obtaining reliable chemical distributions of the stratigraphy materials. Different pigment–binder
combinations have been evaluated in order to understand limitations and strengths of the approach. Finally, the method has
been applied for stratigraphic characterization of a cross-section from a 17th century wooden sculpture identifying both the
original paint layer and the several overpaintings constituting the complex stratigraphy. 相似文献
77.
Consiglio A Grillo G Licciulli F Ceci LR Liuni S Losito N Volpicella M Gallerani R De Leo F 《Current protein & peptide science》2011,12(5):448-454
PlantPIs is a web querying system for a database collection of plant protease inhibitors data. Protease inhibitors in plants are naturally occurring proteins that inhibit the function of endogenous and exogenous proteases. In this paper the design and development of a web framework providing a clear and very flexible way of querying plant protease inhibitors data is reported. The web resource is based on a relational database, containing data of plants protease inhibitors publicly accessible, and a graphical user interface providing all the necessary browsing tools, including a data exporting function. PlantPIs contains information extracted principally from MEROPS database, filtered, annotated and compared with data stored in other protein and gene public databases, using both automated techniques and domain expert evaluations. The data are organized to allow a flexible and easy way to access stored information. The database is accessible at http://www.plantpis.ba.itb.cnr.it/. 相似文献
78.
Back JH Zhu Y Calabro A Queenan C Kim AS Arbesman J Kim AL 《Photochemistry and photobiology》2012,88(5):1165-1172
Macroautophagy is a cellular response to various environmental stresses that ensures lysosomal degradation of long-lived and damaged proteins and cellular organelles. It occurs through the formation of an autophagosome, which then fuses with a lysosome to form an autolysosome. Depending on the cellular context, autophagy may promote cancer cell survival or it may serve as a mechanism of tumor suppression. Herein, we show that resveratrol, a natural phytoalexin, induces premature senescence in human A431 SCC cells, and that resveratrol-induced premature senescence is associated with a blockade of autolysosome formation, as assessed by the absence of colocalization of LC3 and Lamp-2, markers for autophagosomes and lysosomes, respectively. Further, we show that resveratrol downregulates the level of Rictor, a component of mTORC2, leading to decreased RhoA-GTPase and altered actin cytoskeleton organization. Exogenous overexpression of Rictor restores RhoA-GTPase activity and actin cytoskeleton network, and decreases resveratrol-induced senescence-associated β-gal activity, indicating a direct role of Rictor in senescence induction. Rictor is overexpressed in UV-induced murine SCCs, whereas its expression is diminished by oral administration of resveratrol. These data indicate that resveratrol attenuates autophagic process via Rictor, and suggest that downregulation of Rictor may be a mechanism of tumor suppression associated with premature senescence. 相似文献
79.
Iryna Andrusenko Victoria Hamilton Enrico Mugnaioli Arianna Lanza Charlie Hall Jason Potticary Simon R. Hall Mauro Gemmi 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(32):11035-11038
Orthocetamol is a regioisomer of the well‐known pain medication paracetamol and a promising analgesic and an anti‐arthritic medicament itself. However, orthocetamol cannot be grown as single crystals suitable for X‐ray diffraction, so its crystal structure has remained a mystery for more than a century. Here, we report the ab‐initio structure determination of orthocetamol obtained by 3D electron diffraction, combining a low‐dose acquisition method and a dedicated single‐electron detector for recording the diffracted intensities. The structure is monoclinic, with a pseudo‐tetragonal cell that favors multiple twinning on a scale of a few tens of nanometers. The successful application of 3D electron diffraction to orthocetamol introduces a new gold standard of total structure solution in all cases where X‐ray diffraction and electron‐microscope imaging methods fail. 相似文献
80.
Adina Borbély Dr. Eduard Figueras Ana Martins Dr. Lizeth Bodero Dr. André Raposo Moreira Dias Dr. Paula López Rivas Dr. Arianna Pina Dr. Daniela Arosio Dr. Paola Gallinari Dr. Marcel Frese Dr. Christian Steinkühler Prof. Dr. Cesare Gennari Prof. Dr. Umberto Piarulli Prof. Dr. Norbert Sewald 《ChemistryOpen》2019,8(6):737-742
RGD-cryptophycin and isoDGR-cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent tubulin-binding antimitotic agent across lysosomally cleavable Val-Ala or uncleavable linkers. The conjugates were able to effectively inhibit binding of biotinylated vitronectin to integrin αvβ3, showing a binding affinity in the same range as that of the free ligands. The antiproliferative activity of the novel conjugates was evaluated on human melanoma cells M21 and M21-L with different expression levels of integrin αvβ3, showing nanomolar potency of all four compounds against both cell lines. Conjugates containing uncleavable linker show reduced activity compared to the corresponding cleavable conjugates, indicating efficient intracellular drug release in the case of cryptophycin-based SMDCs. However, no significant correlation between the in vitro biological activity of the conjugates and the integrin αvβ3 expression level was observed, which is presumably due to a non-integrin-mediated uptake. This reveals the complexity of effective and selective αvβ3 integrin-mediated drug delivery. 相似文献