全文获取类型
收费全文 | 88篇 |
免费 | 3篇 |
专业分类
化学 | 68篇 |
数学 | 3篇 |
物理学 | 20篇 |
出版年
2021年 | 1篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 3篇 |
2012年 | 9篇 |
2011年 | 10篇 |
2010年 | 8篇 |
2009年 | 1篇 |
2008年 | 3篇 |
2007年 | 7篇 |
2006年 | 4篇 |
2005年 | 3篇 |
2004年 | 6篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1992年 | 2篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1982年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1968年 | 1篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1938年 | 2篇 |
1937年 | 2篇 |
1935年 | 1篇 |
排序方式: 共有91条查询结果,搜索用时 0 毫秒
91.
Birgitta Knopp Bernd Jung Franz-Josef Wortmann 《Macromolecular theory and simulations》1997,6(1):1-12
Simulations of the stability of the secondary and tertiary structure of the α-keratin intermediate filament (IF) monomeric unit of wool are reported. Based on the assumed secondary structure three segments of the primary structure were selected: 1A, L12, and a part of 2B. Starting with an ideal α-helical conformation for each IF-segment, molecular dynamics simulations were carried out on the atomistic level at various temperatures in vaccum using the CFF91 force field. In either simulation the expected destabilization of the helical structure with increasing simulation temperature was observed. By use of different procedures of analysis, transition temperatures for the α-helical denaturation were determined that are significantly higher for the supposedly α-helical segments 1A and 2B than for the linker segment L12. The different stabilities of segments 1A and L12 were further verified through simulations in water environment that show the linker segment to be non-helical at room temperature. The lower transition temperature of segment L12 confirms the expectation that its amino acid sequence leads to increased conformational flexibility. The mobility of the water molecules surrounding the IF-segment is found to be significantly decreased by protein/water interactions. 相似文献