全文获取类型
收费全文 | 8419篇 |
免费 | 1280篇 |
国内免费 | 1447篇 |
专业分类
化学 | 6763篇 |
晶体学 | 192篇 |
力学 | 413篇 |
综合类 | 117篇 |
数学 | 858篇 |
物理学 | 2803篇 |
出版年
2024年 | 21篇 |
2023年 | 117篇 |
2022年 | 318篇 |
2021年 | 327篇 |
2020年 | 365篇 |
2019年 | 406篇 |
2018年 | 327篇 |
2017年 | 318篇 |
2016年 | 447篇 |
2015年 | 466篇 |
2014年 | 557篇 |
2013年 | 680篇 |
2012年 | 766篇 |
2011年 | 797篇 |
2010年 | 584篇 |
2009年 | 622篇 |
2008年 | 621篇 |
2007年 | 572篇 |
2006年 | 457篇 |
2005年 | 425篇 |
2004年 | 356篇 |
2003年 | 236篇 |
2002年 | 264篇 |
2001年 | 198篇 |
2000年 | 147篇 |
1999年 | 166篇 |
1998年 | 114篇 |
1997年 | 93篇 |
1996年 | 91篇 |
1995年 | 58篇 |
1994年 | 54篇 |
1993年 | 39篇 |
1992年 | 29篇 |
1991年 | 16篇 |
1990年 | 23篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 11篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 7篇 |
1983年 | 7篇 |
1982年 | 3篇 |
1981年 | 5篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1973年 | 2篇 |
1959年 | 1篇 |
1935年 | 1篇 |
1909年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
91.
Two natural products databases, the marine natural products database (MNPD) and the traditional Chinese medicines database (TCMD), were used to find novel structures of potent SARS-CoV protease inhibitors through virtual screening. Before the procedure, the databases were filtered by Lipinski's ROF and Xu's extension rules. The results were analyzed by statistic methods to eliminate the bias in target-based database screening toward higher molecular weight compounds for enhancing the hit rate. Eighteen lead compounds were recommended by the screening procedure. They were useful for experimental scientists in prioritizing drug candidates and studying the interaction mechanism. The binding mechanism was also analyzed between the best screening compound and the SARS protein. 相似文献
92.
93.
离聚体水基微乳液化的研究——聚苯乙烯离聚体微乳化过程相反转的表征 总被引:7,自引:0,他引:7
以乙酰磺酸为磺化剂制备磺化度为3~15mol%的磺化聚苯乙烯(SPS)并中和成盐.在一定的温度和搅拌速率下,加水将SPS乳化成水包油的稳定水基微乳液.用乳化过程中体系电导率和粘度的变化表征了乳化相反转过程.研究了溶剂的极性和离子含量对聚苯乙烯离聚体溶液可乳化性和乳化过程及乳液稳定性的影响. 相似文献
94.
Vedejs E Naidu BN Klapars A Warner DL Li VS Na Y Kohn H 《Journal of the American Chemical Society》2003,125(51):15796-15806
An enantiocontrolled route to aziridinomitosenes had been developed from l-serine methyl ester hydrochloride. The tetracyclic target ring system was assembled by an internal azomethine ylide cycloaddition reaction based on silver ion-assisted intramolecular oxazole alkylation and cyanide-induced ylide generation via a labile oxazoline intermediate (62 to 66). Other key steps include reductive detritylation of 26, methylation of the N-H aziridine 56, oxidation of the sensitive cyclohexenedione 68 to quinone 70, and carbamoylation using Fmoc-NCO. Although the aziridinomitosene tetracycle is sensitive, a range of protecting group manipulations and redox chemistry can be performed if suitable precautions are taken. A study of DNA alkylation by the first C-6,C-7-unsubstituted aziridinomitosene 11a has been carried out, and evidence for DNA cross-link formation involving nucleophilic addition to the quinone subunit is described. 相似文献
95.
Lin Jia Hui Yang Jun Deng Junmei Chen Yuan Zhou Pan Ding Leigang Li Na Han Yanguang Li 《中国化学》2019,37(5):497-500
Electrocatalytic carbon dioxide reduction holds great promise for reducing the atmospheric CO2 level and alleviating the energy crisis. High‐performance electrocatalysts are often required in order to lower the high overpotential and expedite the sluggish reaction kinetics of CO2 electroreduction. Copper is a promising candidate metal. However, it usually suffers from the issues of poor stability and low product selectivity. In this work, bimetallic Cu‐Bi is obtained by reducing the microspherical copper bismuthate (CuBi2O4) for selectively catalyzing the CO2 reduction to formate (HCOO–). The bimetallic Cu‐Bi electrocatalyst exhibits high activity and selectivity with the Faradic efficiency over 90% in a wide potential window. A maximum Faradaic efficiency of ~95% is obtained at –0.93 V versus reversible hydrogen electrode. Furthermore, the catalyst shows high stability over 6 h with Faradaic efficiency of ~95%. This study provides an important clue in designing new functional materials for CO2 electroreduction with high activity and selectivity. 相似文献
96.
The fabrication and electrochemical characteristics of a penicillamine (PCA) self-assembled monolayer modified gold electrode were investigated. The self-assembled electrode shows obvious electrocatalytic activity for the oxidation of epinephrine (EP). In phosphate buffer (pH 7.73), a sensitive oxidation peak was observed at 0.190V with the PCA modified Au electrode. The peak current is proportional to the concentration of EP in the range of 2.0×10–56.0×10–4molL–1 and 5.0×10–6 2.0×10–4molL–1 for cyclic voltammetry (CV) and differential pulse voltammetry (DPV) with the detection limits of 1.8×10–7 and 1.3×10–7molL–1, respectively. The possible reaction mechanism is also discussed. The PCA self-assembled monolayer modified gold electrode is highly stable and can be applied to the determination of EP in practical injection samples. Application is simple, rapid and produces accurate results. 相似文献
97.
Chan Sik Cho Na Young Lee Tae‐Jeong Kim Sang Chul Shim 《Journal of heterocyclic chemistry》2004,41(3):423-429
Nitroarenes are reductively cyclized with an array of tetraalkylammonium halides and trialkylarnmonium chlorides in the presence of a catalytic amount of a ruthenium catalyst along with tin(II) chloride dihydrate at 180° to afford the corresponding quinolines in moderate to good yields. The addition of tin(II) chloride dihydrate is necessary for the effective formation of quinolines and toluene is the solvent of choice. A reaction pathway involving initial reduction of nitroarenes to anilines and conversion of alkylammonium halides to alkylamines, alkyl group transfer from alkylamines to anilines to form an imine, dimerization of imine, and heteroannulation is proposed for this catalytic process. 相似文献
98.
99.
FuShengWANG BingKuiSONG XiaoLiHAN BaoGuiZHANG 《中国化学快报》2004,15(12):1487-1490
Black lead, Ti-Ru and Ti-PbO2 were used as anode and stainless steel was used as cathode The electrolytic process of producing hypophosphorous acid with four-compartment electrodialytic cell was studied. The comparison of some factors, such as anodic voltage, product concentration and current efficiency, of black lead, Ti-Ru, and Ti-PbO2 electrodes was conducted. As a result, theTi-PbO2 electrode is the optimal anode material used, it can be in electrolytic process for producing hypophosphorous acid. 相似文献
100.
p-tert-Butylcalix[6]-1,4-2,5-biscrown-4 is a typical member of the family of calix[6]crowns. In the literature, the compound was synthesized from calix[6]arene by two steps and the overall yield based on calix[6]arene was 24%.Herein we wish to report a one-pot method to do this work. By this method the yield was up to 48% and the reaction time was greatly reduced. 相似文献