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41.
42.
Response of saturated porous media subjected to local thermal loading on the surface of semi-infinite space 总被引:2,自引:0,他引:2
Bing Bai 《Acta Mechanica Sinica》2006,22(1):54-61
Heat source function method is adopted in the present paper to derive elementary solutions of coupled thermo-hydro-mechanical
consolidation for saturated porous media under conjunct actions of instantaneous point heat source, instantaneous point fluid
source and constant volume force. By using the so-called fictitious heat source method and images method, the solutions of
a semi-infinite saturated porous medium subjected to a local heat source with time-varied intensity on its free surface are
developed from elementary solutions. The numerical integral methods for calculating the unsteady temperature, pore pressure
and displacement fields are given. The thermomechanical response are analyzed for the case of a circular planar heat source.
Besides, the thermal consolidation characteristics of a saturated porous medium subjected to a harmonic thermal loading are
also given, and the fluctuation processes of the field variables located below the center of heat source are analyzed.
The project supported by the National Natural Science Foundation of China (50578008) The English text was polished byYunming
Chen. 相似文献
43.
Kai Sun Anzai Shi Yan Liu Xiaolan Chen Panjie Xiang Xiaotong Wang Lingbo Qu Bing Yu 《Chemical science》2022,13(19):5659
General photoactivation of electron donor–acceptor (EDA) complexes between arylsulfonium salts and 1,4-diazabicyclo[2.2.2]octane with visible light or natural sunlight was discovered. This practical and efficient mode enables the production of aryl radicals under mild conditions, providing an unrealized opportunity for two-step para-selective C–H functionalization of complex arenes. The novel mode for generating aryl radicals via an EDA complex was well supported by UV-vis absorbance measurements, nuclear magnetic resonance titration experiments, and density functional theory (DFT) calculations. The method was applied to the regio- and stereo-selective arylation of various N-heterocycles under mild conditions, yielding an assembly of challengingly linked heteroaryl–(hetero)aryl products. Remarkably, the meaningful couplings of bioactive molecules with structurally complex drugs or agricultural pharmaceuticals were achieved to display favorable in vitro antitumor activities, which will be of great value in academia or industry.General photoactivation of EDA complexes between arylsulfonium salts and 1,4-diazabicyclo[2.2.2]octane was discovered. This practical mode enables the generation of aryl radicals for C–H functionalization of arenes. 相似文献
44.
Huyeon Choi Gaeun Park Eunhye Shin Seon Woo Shin Batakrishna Jana Seongeon Jin Sangpil Kim Huaimin Wang Sang Kyu Kwak Bing Xu Ja-Hyoung Ryu 《Chemical science》2022,13(21):6197
Mitochondria are essential intracellular organelles involved in many cellular processes, especially adenosine triphosphate (ATP) production. Since cancer cells require high ATP levels for proliferation, ATP elimination can be a unique target for cancer growth inhibition. We describe a newly developed mitochondria-targeting nucleopeptide (MNP) that sequesters ATP by self-assembling with ATP inside mitochondria. MNP interacts strongly with ATP through electrostatic and hydrogen bonding interactions. MNP exhibits higher binding affinity for ATP (−637.5 kJ mol−1) than for adenosine diphosphate (ADP) (−578.2 kJ mol−1). To improve anticancer efficacy, the small-sized MNP/ADP complex formed large assemblies with ATP inside cancer cell mitochondria. ATP sequestration and formation of large assemblies of the MNP/ADP–ATP complex inside mitochondria caused physical stress by large structures and metabolic disorders in cancer cells, leading to apoptosis. This work illustrates a facile approach to developing cancer therapeutics that relies on molecular assemblies.Mitochondria-targeting nucleopeptide (MNP) can sequester ATP by self-assembling with ATP. A small nanosized MNP/ADP complex forms a large assembly with ATP. Thus, intramitochondrial co-assembly causes stress by large structures and apoptosis. 相似文献
45.
Two copper(Ⅱ)coordination polymers{[Cu(bib)(nip)]·1.5H2O}n(1)and[Cu2(bib)(glu)2]n(2)(bib= 1,4-bis(2-methyl-imidazol-1-yl)butane,H2nip = 5-nitroisophthalic acid,... 相似文献
46.
47.
In this paper, the authors give some sufficient conditions for an amalgamated
3-manifold along a compact connected surface F with boundary to be ?-irreducible in
terms of distances between some kinds of vertex subsets of the curve complex and the arc
complex of F. 相似文献
48.
The understanding of amphiphilic block copolymers(ABC)in encapsulation and transport of inorganic nanomedicines is highly desired.Still,it remains limited due to the challenges in the fabrication of nanoassemblies(NAs)with highly-controlled shape and loading of nanoparticles.Herein,through growth regulation of luminescent gold nanoparticles(Au NPs)by different reductants with ABC pluronic F127 as a template,a straightforward strategy is reported for in-situ fabrication of three wellcontrolled gold NAs(Au NAs)that display tunable shapes from spherical to elongated nanostructures and controllable surface chemistry and loading of Au NPs with distinct emissions but identical individual Au NP size.The three Au NAs exhibit tailored invivo transport behaviours:those with spherical shape and more hydrophilic surface show longer blood retention with higher tumor-targeting efficiency(~25.3%injection dose/g)and excellent long-term near-infrared tumor imaging even after 96 h postinjection.These findings provide a useful guidance in designing specific nanostructures for future nanomedicine transport. 相似文献
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