Saccharin as a salt former. Enhanced solubilities of saccharinates of active pharmaceutical ingredients

Saccharin, acting as a weak acid, forms salts with basic APIs and these salts have the desirable property of enhanced water solubility.     

Dichlorocarbene Addition to

In contrast to the terminal phosphinidene complex PhPW(CO)(5) (2), which adds to [5]metacyclophane (1) in a 1,4-fashion, dichlorocarbene preferentially adds in a 1,2-fashion to the formal "anti-Bredt" type double bond of the aromatic ring of 1 to afford the norcaradiene 11b, which immediately rearranges to the bridged cycloheptatriene 12b and further by a [1,5] sigmatropic chlorine migration to the isomeric 13b as the first observable product. More slowly, the latter isomerizes via a dissociative mechanism to give 15b. A computational study supports the notion that the [1,5] chlorine migration in the rearrangement 12b --> 13b, for which an activation barrier of 70.2 kJ mol(-)(1) was calculated, is essentially concerted with minor charge separation. In contrast, the analogous [1,5] chlorine migration in the flat model compound 7,7-dichlorocycloheptatriene (12a) displays features of a dissociative pathway.     

Facile conversion of electron rich benzylic hydrocarbons to carbonyl compounds by peroxydisulphate and copper ions

A convenient method for the conversion of electron rich benzylic hydrocarbons to carbonyl compounds is reported.     

The deformation producing tendency of (d 3/2−f 7/2) empirical effective interaction

The effective matrix elements in (d _3/2−f _7/2)² configuration have been recently defined by Erskineet al. and Sherret al. assuming shell clcsures for S³² and Ca⁴⁰. We have attempted to verify whether this empirically deduced (d _3/2−f _7/2)² interaction permits thed _3/2 shell to remain closed when nucleons are added to Ca⁴⁰. It is found that the Erskine interaction gives rise to ground states of thef _7/2 shell nuclei in which thed _3/2 orbit is completely filled. However that interaction over-binds Ca⁴⁰. If the centroid of the (d _3/2)² interaction is modified to fit the Ca⁴⁰ binding energy, the ground states of Cr⁴⁸ and Fe⁵² become deformed and thed _3/2 orbit is not completely filled.     

Enhanced isospin dependence of the empirical particle-hole effective interaction

The separation betweenT=0 andT=1 centroids of the empirical effective interaction is fairly large for the (d ₃ ^2/−1 f _7/2)JT particle-hole interaction as compared to nearby (f _7/2)² JT and (d _5/2)² JT particle-particle interactions. This interesting feature of the empirical effective interaction is shown to arise as a consequence of renormalization of the effective interaction as one truncates the configuration space from (s−d)⁻¹(f−p)¹ to (d ₃ ^2/−1 f _7/2) and from (f−p)² and (s−d)² configurations to (f _7/2)² and (d _5/2)² respectively.     

On the summability factors of infinite series

The author has established that if [λ_n] is a convex sequence such that the series Σn ^-1λ_n is convergent and the sequence {K _n} satisfies the condition |K _n|=O[log(n+1)]^k(C, 1),k?0, whereK _n denotes the (R, logn, 1) mean of the sequence {n log (n+1)a _n}, then the series Σlog(n+1)^1-kλ_n a _n is summable |R, logn, 1|. The result obtained for the particular casek=0 generalises a previous result of the author [1].     

Shell model spectra of92Tc and93Ru

Shell model calculations for the nuclei⁹¹Mo,⁹²Tc and⁹³Ru in the Talmi approach have been done. The ground state binding energies and the excitation spectra agree with experiment.