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排序方式: 共有192条查询结果,搜索用时 309 毫秒
101.
Wilson H. C. Freire V. B. Bezerra J. A. S. Lima 《General Relativity and Gravitation》2001,33(8):1407-1414
We investigate the perihelion shift of the planetary motion and the bending of starlight in the Schwarzschild field modified by the presence of a -term plus a conical defect. This analysis generalizes an earlier result obtained by Islam (Phys. Lett. A 97, 239, 1983) to the case of a pure cosmological constant. By using the experimental data we obtain that the parameter characterizing the conical defect is less than 10–9 and 10–7, respectively, on the length scales associated with such phenomena. In particular, if the defect is generated by a cosmic string, these values correspond to limits on the linear mass densities of 1019 g/cm and 1021 g/cm, respectively. 相似文献
102.
Exploitation of the Z-scan technique as a method to optically probe pK(a) in organic materials: application to porphyrin derivatives 总被引:1,自引:0,他引:1
We demonstrate the use of the Z-scan technique as a method to measure a chemical parameter, the pK(a) value, that characterizes the equilibrium constant in acid-base reactions. The measurements were performed with picosecond pulses at 532 nm in Fe(III)-meso-tetrakis(4-N-methyl-pyridyl) porphyrin. The results were compared with linear absorption measurements and electron paramagnetic resonance, the usual techniques employed to determine pK(a) values in aqueous solutions, and showed excellent agreement. 相似文献
103.
Pedro Correia S. Bezerra Pedro Henrique M. Albuquerque 《Computational Management Science》2017,14(2):179-196
The support vector regression (SVR) is a supervised machine learning technique that has been successfully employed to forecast financial volatility. As the SVR is a kernel-based technique, the choice of the kernel has a great impact on its forecasting accuracy. Empirical results show that SVRs with hybrid kernels tend to beat single-kernel models in terms of forecasting accuracy. Nevertheless, no application of hybrid kernel SVR to financial volatility forecasting has been performed in previous researches. Given that the empirical evidence shows that the stock market oscillates between several possible regimes, in which the overall distribution of returns it is a mixture of normals, we attempt to find the optimal number of mixture of Gaussian kernels that improve the one-period-ahead volatility forecasting of SVR based on GARCH(1,1). The forecast performance of a mixture of one, two, three and four Gaussian kernels are evaluated on the daily returns of Nikkei and Ibovespa indexes and compared with SVR–GARCH with Morlet wavelet kernel, standard GARCH, Glosten–Jagannathan–Runkle (GJR) and nonlinear EGARCH models with normal, student-t, skew-student-t and generalized error distribution (GED) innovations by using mean absolute error (MAE), root mean squared error (RMSE) and robust Diebold–Mariano test. The results of the out-of-sample forecasts suggest that the SVR–GARCH with a mixture of Gaussian kernels can improve the volatility forecasts and capture the regime-switching behavior. 相似文献
104.
Mariana de Oliveira Silva John Nonvignon Bossis Honfoga Lorena Lucena de Medeiros Marta Suely Madruga Taliana Kênia Alencar Bezerra 《Molecules (Basel, Switzerland)》2021,26(1)
Coffee husks (Coffea arabica L.) are characterized by exhibiting secondary metabolites such as phenolic compounds, which can be used as raw material for obtaining bioactive compounds of interest in food. The objective of this study is to evaluate different methods for obtaining the raw material and extracting solutions of bioactive compounds from coffee husks. Water bath and ultrasound-assisted extraction methods were used, using water (100%) or ethanol (100%) or a mixture of both (1:1) as extracting solutions and the form of the raw material was in natura and dehydrated. The extracts were evaluated by their antioxidant potential using DPPH radicals, ABTS, and iron reduction (ferric reducing antioxidant power (FRAP)), and later total phenolic compounds, total flavonoids, and condensed tannins were quantified the phenolic majority compounds were identified. It was verified that the mixture of water and ethanol (1:1) showed better extraction capacity of the compounds with antioxidant activity and that both conventional (water bath) or unconventional (ultrasound) methods showed satisfactory results. Finally, a satisfactory amount of bioactive compounds was observed in evaluating the chemical composition (total phenolic compounds, total flavonoids, condensed tannins, as well as the analysis of the phenolic profile) of these extracts. Corroborating with the results of the antioxidant activities, the best extracting solution was generally the water and ethanol mixture (1:1) using a dehydrated husk and water bath as the best method, presenting higher levels of the bioactive compounds in question, with an emphasis on chlorogenic acid. Thus, it can be concluded that the use of coffee husk as raw material to obtain extracts of bioactive compounds is promising. Last, the conventional method (water bath) and the water and ethanol mixture (1:1) stood out among the methods and extracting solutions used for the dehydrated coffee husk. 相似文献
105.
Chonny Herrera-Acevedo Areli Flores-Gaspar Luciana Scotti Francisco Jaime Bezerra Mendona-Junior Marcus Tullius Scotti Ericsson Coy-Barrera 《Molecules (Basel, Switzerland)》2021,26(11)
The current treatments against Leishmania parasites present high toxicity and multiple side effects, which makes the control and elimination of leishmaniasis challenging. Natural products constitute an interesting and diverse chemical space for the identification of new antileishmanial drugs. To identify new drug options, an in-house database of 360 kauranes (tetracyclic diterpenes) was generated, and a combined ligand- and structure-based virtual screening (VS) approach was performed to select potential inhibitors of Leishmania major (Lm) pteridine reductase I (PTR1). The best-ranked kauranes were employed to verify the validity of the VS approach through LmPTR1 enzyme inhibition assay. The half-maximal inhibitory concentration (IC50) values of selected bioactive compounds were examined using the random forest (RF) model (i.e., 2β-hydroxy-menth-6-en-5β-yl ent-kaurenoate (135) and 3α-cinnamoyloxy-ent-kaur-16-en-19-oic acid (302)) were below 10 μM. A compound similar to 302, 3α-p-coumaroyloxy-ent-kaur-16-en-19-oic acid (302a), was also synthesized and showed the highest activity against LmPTR1. Finally, molecular docking calculations and molecular dynamics simulations were performed for the VS-selected, most-active kauranes within the active sites of PTR1 hybrid models, generated from three Leishmania species that are known to cause cutaneous leishmaniasis in the new world (i.e., L. braziliensis, L. panamensis, and L. amazonensis) to explore the targeting potential of these kauranes to other species-dependent variants of this enzyme. 相似文献
106.
We have performed a theoretical study of the specific heat C(T), as a function of temperature, of magnetic and semiconductor quasiperiodic structures. The quasiperiodic structures considered here are constructed according to the Fibonacci, double-period and Thue–Morse quasiperiodic sequences. On one hand, we assume the magnetic structures composed of ferromagnetic films, each one described by the Heisenberg model. On the other hand, we consider semiconductor structures composed of slabs of AlN and GaN, which are characterized by the dielectric functions εA(ω) and εB(ω), and have thicknesses da and db, respectively. Our results illustrate the effects of disorder on the oscillatory behavior of the specific heat in the low temperature regime. 相似文献
107.
Rocha MV Souza MC Benedicto SC Bezerra MS Macedo GR Pinto GA Gonçalves LR 《Applied biochemistry and biotechnology》2007,137(1-12):185-194
In this work, the ability of biosurfactant production by Pseudomonas aeruginosa in batch cultivation using cashew apple juice (CAJ) and mineral media was evaluated. P. aeruginosa was cultivated in CAJ, which was supplemented with peptone (5.0 g/L) and nutritive broth. All fermentation assays were performed in Erlenmeyer flasks containing 300 mL, incubated at 30 degrees C and 150 rpm. Cell growth (biomass and cell density), pH, and superficial tension were monitored vs time. Surface tension was reduced by 10.58 and 41% when P. aeruginosa was cultivated in nutrient broth and CAJ supplemented with peptone, respectively. These results indicated that CAJ is an adequate medium for growth and biosurfactant production. Best results of biosurfactant production were obtained when CAJ was supplemented with peptone. 相似文献
108.
Kallyne Sousa Soares Marthyna Pessoa Souza Edson C. Silva-Filho Hernane Silva Barud Clvis Augusto Ribeiro Digenes Dias Santos Karla Nayalle Souza Rocha Jos Fabio Paulino de Moura Ronaldo Lopes Oliveira Leilson Rocha Bezerra 《Molecules (Basel, Switzerland)》2021,26(23)
The production of edible film from onion (Allium cepa L.) to be applied as packaging is attractive, due to its chemical properties and biodegradable characteristics. Thus, we tested the hypothesis that edible onion film can positively influence the sensory properties, quality and increasing shelf life of beef burgers patties. The experiment was designed in a 4 × 2 factorial scheme, with two treatments (beef burgers patties with or without edible onion film) at an interval of four storage times (0, 3, 6 and 9 days) at 4 °C. The uncoated burger patties (control) suffered the most intense color modifications during the storage (p < 0.05). The luminosity index was higher (p < 0.05) in the control at all storage times, except at day 6, and redness, yellowness and chrome were higher (p < 0.05) in the edible onion film patties at all storage times. The pH of the beef burger patties was lower (p < 0.05) at all storage times when the edible onion film was applied. For the texture profile, only the chewiness was affected, as the inclusion of the edible onion film improved the chewing of the beef burgers patties over the storage time (p < 0.05). Additionally, there was an inhibition of the microbial growth of mesophiles and psychrophiles with the application of the edible onion film in beef burgers patties. The use of edible onion film improved the perception of panelists for the variables texture, color, flavor, odor and overall appearance, and increased the preference of panelists. The edible onion film is recommended for preserving beef burgers patties, as it delays the proliferation of unwanted microorganisms, stabilizes and improves the color parameters and sensory attributes, and increases the overall acceptance of the consumer. 相似文献
109.
Luiz Jardelino de Lacerda Neto Andreza Guedes Barbosa Ramos Thiago Sampaio de Freitas Cristina Rodrigues dos Santos Barbosa Drcio Luiz de Sousa Júnior Abolghasem Siyadatpanah Morteza Nejat Polrat Wilairatana Henrique Douglas Melo Coutinho Francisco Assis Bezerra da Cunha 《Molecules (Basel, Switzerland)》2021,26(18)
Products of natural origin remain important in the discovery of new bioactive molecules and are less damaging to the environment. Benzaldehyde is a product of the metabolism of plants, and similarly to oxygenated terpenes, it can have antibacterial activity against Staphylococcus aureus and toxic action against Drosophila melanogaster; we aimed to verify these activities. The broth microdilution tests determined the minimum inhibitory concentration (MIC) of benzaldehyde alone and in association with antibiotics and ethidium bromide (EtBr). Toxicity against Drosophila melanogaster was determined by fumigation tests that measured lethality and damage to the locomotor system. The results indicated that there was an association of norfloxacin and ciprofloxacin with benzaldehyde, from 64 μg/mL to 32 μg/mL of ciprofloxacin in the strain K6028 and from 256 μg/mL to 128 μg/mL of norfloxacin in the strain 1199B; however, the associations were not able to interfere with the functioning of the tested efflux pumps. In addition, benzaldehyde had a toxic effect on flies. Thus, the results proved the ability of benzaldehyde to modulate quinolone antibiotics and its toxic effects on fruit flies, thus enabling further studies in this area. 相似文献
110.
Response surface methodology (RSM) as a tool for optimization in analytical chemistry 总被引:19,自引:0,他引:19
A review about the application of response surface methodology (RSM) in the optimization of analytical methods is presented. The theoretical principles of RSM and steps for its application are described to introduce readers to this multivariate statistical technique. Symmetrical experimental designs (three-level factorial, Box-Behnken, central composite, and Doehlert designs) are compared in terms of characteristics and efficiency. Furthermore, recent references of their uses in analytical chemistry are presented. Multiple response optimization applying desirability functions in RSM and the use of artificial neural networks for modeling are also discussed. 相似文献