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11.
Saxon E Luchansky SJ Hang HC Yu C Lee SC Bertozzi CR 《Journal of the American Chemical Society》2002,124(50):14893-14902
The structure of sialic acid on living cells can be modulated by metabolism of unnatural biosynthetic precursors. Here we investigate the conversion of a panel of azide-functionalized mannosamine and glucosamine derivatives into cell-surface sialosides. A key tool in this study is the Staudinger ligation, a highly selective reaction between modified triarylphosphines and azides that produces an amide-linked product. A preliminary study of the mechanism of this reaction, and refined conditions for its in vivo execution, are reported. The reaction provided a means to label the glycoconjugate-bound azidosugars with biochemical probes. Finally, we demonstrate that the cell-surface Staudinger ligation is compatible with hydrazone formation from metabolically introduced ketones. These two strategies provide a means to selectively modify cell-surface glycans with exogenous probes. 相似文献
12.
[reaction: see text] The synthesis of alpha-substituted alpha,beta-enones by a new metal iodide-promoted one-pot three-component reaction involving commercially available cyclopropyl ketones, aldehydes, and secondary amines followed by base treatment is described. 相似文献
13.
Joo K Smith LC Burkert VD Minehart R Aznauryan IG Elouadrhiri L Stepanyan S Adams GS Amaryan MJ Anciant E Anghinolfi M Armstrong DS Asavapibhop B Audit G Auger T Avakian H Barrow S Bagdasaryan H Battaglieri M Beard K Bektasoglu M Bertozzi W Bianchi N Biselli AS Boiarinov S Bonner BE Brooks WK Calarco JR Capitani GP Carman DS Carnahan B Cole PL Coleman A Cords D Corvisiero P Crabb D Crannell H Cummings J De Sanctis E De Vita R Degtyarenko PV Demirchyan RA Denizli H Dennis LC Deppman A 《Physical review letters》2002,88(12):122001
Models of baryon structure predict a small quadrupole deformation of the nucleon due to residual tensor forces between quarks or distortions from the pion cloud. Sensitivity to quark versus pion degrees of freedom occurs through the Q2 dependence of the magnetic (M1+), electric (E1+), and scalar (S1+) multipoles in the gamma*p-->Delta(+)-->p pi(0) transition. We report new experimental values for the ratios E(1+)/M(1+) and S(1+)/M(1+) over the range Q2 = 0.4-1.8 GeV2, extracted from precision p(e,e(')p)pi(0) data using a truncated multipole expansion. Results are best described by recent unitary models in which the pion cloud plays a dominant role. 相似文献
14.
Tyrosine sulfation is a post-translational modification of many secreted and membrane-bound proteins. Its biological roles have been unclear. Recent work has implicated tyrosine sulfate as a determinant of protein-protein interactions involved in leukocyte adhesion, hemostasis and chemokine signaling. 相似文献
15.
Rossi P Mirazita M Ronchetti F De Sanctis E Adams G Ambrozewicz P Anciant E Anghinolfi M Asavapibhop B Audit G Avakian H Bagdasaryan H Ball JP Barrow S Battaglieri M Beard K Bektasoglu M Bellis M Benmouna N Berman BL Bertozzi W Bianchi N Biselli AS Boiarinov S Bonner BE Bouchigny S Bradford R Branford D Briscoe WJ Brooks WK Burkert VD Butuceanu C Calarco JR Carman DS Carnahan B Chen S Cole PL Cords D Corvisiero P Crabb D Crannell H Cummings JP De Vita R Degtyarenko PV Denizli H Dennis L 《Physical review letters》2005,94(1):012301
16.
Laveissière G Todor L Degrande N Jaminion S Jutier C Di Salvo R Van Hoorebeke L Alexa LC Anderson BD Aniol KA Arundell K Audit G Auerbach L Baker FT Baylac M Berthot J Bertin PY Bertozzi W Bimbot L Boeglin WU Brash EJ Breton V Breuer H Burtin E Calarco JR Cardman LS Cavata C Chang CC Chen JP Chudakov E Cisbani E Dale DS de Jager CW De Leo R Deur A d'Hose N Dodge GE Domingo JJ Elouadrhiri L Epstein MB Ewell LA Finn JM Fissum KG Fonvieille H Fournier G Frois B Frullani S Furget C Gao H Gao J 《Physical review letters》2004,93(12):122001
We report a virtual Compton scattering study of the proton at low c.m. energies. We have determined the structure functions P(LL)-P(TT)/epsilon and P(LT), and the electric and magnetic generalized polarizabilities (GPs) alpha(E)(Q2) and beta(M)(Q2) at momentum transfer Q(2)=0.92 and 1.76 GeV2. The electric GP shows a strong falloff with Q2, and its global behavior does not follow a simple dipole form. The magnetic GP shows a rise and then a falloff; this can be interpreted as the dominance of a long-distance diamagnetic pion cloud at low Q2, compensated at higher Q2 by a paramagnetic contribution from piN intermediate states. 相似文献
17.
18.
K. A. Aniol M. B. Epstein E. Gama D. J. Margaziotis W. Bertozzi J. P. Chen D. Dale R. E. J. Florizone S. Gilad A. J. Sarty J. A. Templon S. P. Van Verst J. Zhao Z. -L. Zhou P. Bartsch W. U. Boeglin R. Boehm M. O. Distler I. Ewald J. M. Friedrich J. M. Friedrich R. Geiges P. Jennewein M. Kahrau K. W. Krygier A. Liesenfeld H. Merkel K. Merle U. Muller R. Neuhausen E. A. J. M. Offermann Th. Pospischil G. Rosner H. Schmieden A. Wagner Th. Walcher M. Kuss A. Richter G. Schrieder K. Bohinc M. Potokar S. Širca J. M. Udias Javier R. Vignote R. Schiavilla 《The European Physical Journal A - Hadrons and Nuclei》2004,22(3):449-454
We have measured the 4He(e, ep)3H reaction at missing momenta of 130-300 MeV/c using the three-spectrometer facility at the Mainz microtron MAMI. Data were taken in perpendicular kinematics to allow us to determine the response function RLT and the asymmetry term ATL. The data are compared to both relativistic and non-relativistic calculations. 相似文献
19.
Background
Growth hormone (GH) plays an incompletely understood role in the development of the central nervous system (CNS). In this study, we use transgenic mice expressing a growth hormone antagonist (GHA) to explore the role of GH in regulating postnatal brain, spinal cord and body growth into adulthood. The GHA transgene encodes a protein that inhibits the binding of GH to its receptor, specifically antagonizing the trophic effects of endogenous GH. 相似文献20.
Fatemi R Skabelin AV Burkert VD Crabb D De Vita R Kuhn SE Minehart R Adams G Anciant E Anghinolfi M Asavapibhop B Audit G Auger T Avakian H Bagdasaryan H Ball JP Barrow S Battaglieri M Beard K Bektasoglu M Bellis M Bertozzi W Bianchi N Biselli AS Boiarinov S Bonner BE Bosted PE Bouchigny S Bradford R Branford D Brooks WK Butuceanu C Calarco JR Carman DS Carnahan B Cetina C Ciciani L Clark R Cole PL Coleman A Connelly J Cords D Corvisiero P Crannell H Cummings JP De Sanctis E Degtyarenko PV 《Physical review letters》2003,91(22):222002
Double-polarization asymmetries for inclusive ep scattering were measured at Jefferson Lab using 2.6 and 4.3 GeV longitudinally polarized electrons incident on a longitudinally polarized NH3 target in the CLAS detector. The polarized structure function g(1)(x,Q2) was extracted throughout the nucleon resonance region and into the deep inelastic regime, for Q(2)=0.15-1.64 GeV2. The contributions to the first moment Gamma(1)(Q2)= integral g(1)(x,Q2) dx were determined up to Q(2)=1.2 GeV2. Using a parametrization for g(1) in the unmeasured low x regions, the complete first moment was estimated over this Q2 region. A rapid change in Gamma(1) is observed for Q2<1 GeV2, with a sign change near Q(2)=0.3 GeV2, indicating dominant contributions from the resonance region. At Q(2)=1.2 GeV2 our data are below the perturbative QCD evolved scaling value. 相似文献