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21.
Paulina X. Medina Rangel Elena Moroni Franck Merlier Prof. Levi A. Gheber Prof. Razi Vago Dr. Bernadette Tse Sum Bui Prof. Karsten Haupt 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(7):2838-2844
One of the most promising strategies to treat cancer is the use of therapeutic antibodies that disrupt cell–cell adhesion mediated by dysregulated cadherins. The principal site where cell–cell adhesion occurs encompasses Trp2 found at the N-terminal region of the protein. Herein, we employed the naturally exposed highly conserved peptide Asp1-Trp2-Val3-Ile4-Pro5-Pro6-Ile7, as epitope to prepare molecularly imprinted polymer nanoparticles (MIP-NPs) to recognize cadherins. Since MIP-NPs target the site responsible for adhesion, they were more potent than commercially available therapeutic antibodies for inhibiting cell–cell adhesion in cell aggregation assays, and for completely disrupting three-dimensional tumor spheroids as well as inhibiting invasion of HeLa cells. These biocompatible supramolecular anti-adhesives may potentially be used as immunotherapeutic or sensitizing agents to enhance antitumor effects of chemotherapy. 相似文献
22.
Stephen Lane Bernadette C. Proemse Alexander Tennant Michael E. Wieser 《Analytical and bioanalytical chemistry》2013,405(9):2957-2963
Here, we report the first measurements of the molybdenum (Mo) isotopic composition of aerosols collected on Teflon air filters. Mo concentrations and isotopic compositions were measured at selected locations in the city of Calgary, Canada, including a residence, the isotope laboratory at the University of Calgary, the University of Calgary weather station, and the City of Calgary Transit bus garage. Concentrations ranged from 0.07 ng/m3 in the laboratory to 19.0 ng/m3 in the bus garage. The concentrations of Mo in the air samples collected in the bus garage were the highest measured in this study. To date, there are no reported data for the Mo isotopic composition of airborne Mo. In this study, the δ98/95Mo values measured for the different urban sampling sites and reported relative to SRM 3134, ranged from ?0.18 to +0.94 ‰. The results of this investigation suggest that measurements of Mo concentrations and isotopic compositions have the potential to trace anthropogenic emissions in an urban environment. 相似文献
23.
Julien Nicolas Ségolène Brusseau Bernadette Charleux 《Journal of polymer science. Part A, Polymer chemistry》2010,48(1):34-47
Nitroxide‐mediated controlled/living free‐radical polymerization of methyl methacrylate initiated by the SG1‐based alkoxyamine BlocBuilder was successfully performed in bulk at 80–99 °C with the help of a very small amount of acrylonitrile (AN, 2.2–8.8 mol %) as a comonomer. Well‐defined PMMA‐rich P(MMA‐co‐AN) copolymers were prepared with the number‐average molar mass, Mn, in the 6.1–32 kg mol?1 range and polydispersity indexes as low as 1.24. Incorporation of AN in the copolymers was demonstrated by 1H and 13C NMR spectroscopy, and its effect on the chain thermal properties was evaluated by DSC and TGA analyses. Investigation of chain‐end functionalization by an alkoxyamine group was performed by means of 31P NMR spectroscopy and chain extensions from a P(MMA‐co‐AN)‐SG1 macroinitiator. It demonstrated the very high proportion of SG1‐terminated polymer chains, which opened the door to block copolymer synthesis with a high quality of control. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 34–47, 2010 相似文献
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Rotational analysis of bands with v′ = 0 through 3, in the 1Π-X1Σ+ system as the AsN molecule, has been carried out. Rotational constants for the X1Σ+ state are: Be = 0.54551 cm?1, αe = 0.003366 cm?1 and De = 5.3 × 10?7cm?1. Strong perturbations are observed in the upper levels and the resulting Bv curves are plotted against J. 相似文献
26.
Bernadette Perrin-Riou 《Journal of the American Mathematical Society》2000,13(3):533-551
Let be a crystalline -adic representation of the absolute Galois group of an finite unramified extension of , and let be a lattice of stable by . We prove the following result: Let be the maximal sub-representation of with Hodge-Tate weights strictly positive and . Then, the projective limit of is equal up to torsion to the projective limit of . So its rank over the Iwasawa algebra is .
27.
Stéphanie Boissé Jutta Rieger Gaëlle Pembouong Patricia Beaunier Bernadette Charleux 《Journal of polymer science. Part A, Polymer chemistry》2011,49(15):3346-3354
Aqueous emulsion polymerizations of styrene were performed in the presence of a macromolecular reversible addition‐fragmentation chain transfer (RAFT) agent (macroRAFT) composed of acrylic acid (AA) and poly(ethylene oxide) methyl ether acrylate (PEOA), end‐capped by a reactive dodecyl trithiocarbonate group (P(AA‐co‐PEOA)‐TTC). The influence of the stirring speed or the presence of different amounts of a divalent salt, CaCl2, were investigated in this polymerization‐induced self‐assembly process, in which spherical and nonspherical nano‐objects were formed upon the synthesis of amphiphilic diblock copolymers in situ. It appeared that the addition of CaCl2 led to the controlled formation of different nano‐objects such as spheres, fibers or vesicles, whereas an appropriate stirring speed was required for the formation of nanofibers. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011 相似文献
28.
Colleran JJ Creaven BS Donlon DF McGinley J 《Dalton transactions (Cambridge, England : 2003)》2010,39(45):10928-10936
Mercury ion complexation reactions were carried out between 3 and various mercury(II) salts. (1)H NMR studies showed that the role of solvent, the anion chosen and the initial reaction conditions were critical and that the formation of a "simple" mercury(II) complex was non-trivial. The mercury(II) ion can cause either (i) the formation of an ion-pair system, which have a characteristic doubling of all signals in the (1)H NMR spectrum, (ii) a cleavage reaction to occur resulting in the reformation of the calix[4]arene diester compound 2, but only when the reaction is heated and (iii) "simple" mercury binding to the pyridine rings when the binding studies are carried out using NMR titration techniques. The electrochemistry results, on the same systems, show that the initial reaction involves the removal of the phenoxide protons followed by the resulting catalysis of the mercury species. This proton removal is not observed in the NMR spectra of any of the mercury reactions. It was also found that 3 could bind silver and zinc salts and was not selective for mercury(II) as was previously described. 相似文献
29.
Benjamin Debrus Pierre Lebrun Attilio Ceccato Gabriel Caliaro Bernadette Govaerts Bernard A. Olsen Eric Rozet Bruno Boulanger Philippe Hubert 《Talanta》2009,79(1):77-85
One of the major issues within the context of the fully automated development of chromatographic methods consists of the automated detection and identification of peaks coming from complex samples such as multi-component pharmaceutical formulations or stability studies of these formulations. The same problem can also occur with plant materials or biological matrices. This step is thus critical and time-consuming, especially when a Design of Experiments (DOE) approach is used to generate chromatograms. The use of DOE will often maximize the changes of the analytical conditions in order to explore an experimental domain. Unfortunately, this generally provides very different and “unpredictable” chromatograms which can be difficult to interpret, thus complicating peak detection and peak tracking (i.e. matching peaks among all the chromatograms). In this context, Independent Components Analysis (ICA), a new statistically based signal processing methods was investigated to solve this problem. The ICA principle assumes that the observed signal is the resultant of several phenomena (known as sources) and that all these sources are statistically independent. Under those assumptions, ICA is able to recover the sources which will have a high probability of representing the constitutive components of a chromatogram. In the present study, ICA was successfully applied for the first time to HPLC–UV-DAD chromatograms and it was shown that ICA allows differentiation of noise and artifact components from those of interest by applying clustering methods based on high-order statistics computed on these components. Furthermore, on the basis of the described numerical strategy, it was also possible to reconstruct a cleaned chromatogram with minimum influence of noise and baseline artifacts. This can present a significant advance towards the objective of providing helpful tools for the automated development of liquid chromatography (LC) methods. It seems that analytical investigations could be shortened when using this type of methodologies. 相似文献
30.
Cover Picture: Velocity of a Molecule Evaporated from a Water Nanodroplet: Maxwell–Boltzmann Statistics versus Non‐Ergodic Events (Angew. Chem. Int. Ed. 49/2015) 下载免费PDF全文
Assist. Prof. Dr. Hassan Abdoul‐Carime Francis Berthias Dr. Linda Feketeová Dr. Mathieu Marciante Dr. Florent Calvo Dr. Valérian Forquet Prof. Dr. Henry Chermette Dr. Bernadette Farizon Prof. Dr. Michel Farizon Prof. Dr. Tilmann D. Märk 《Angewandte Chemie (International ed. in English)》2015,54(49):14587-14587