(2RS,5SR,6SR)‐Methyl 4‐{cis‐2‐[3‐fluoro‐5‐(4‐methoxy‐3,4,5,6‐tetrahydro‐2H‐pyran‐4‐yl)phenoxy­methyl]‐6‐hydroxy‐3‐phenylmorpholino}­benzene­sulfinate

The title compound, C₃₀H₃₄FNO₇S, is a key inter­mediate in the design of dual 5‐LOX (5‐lipoxygenase)/COX‐2 (cyclo­oxygenase‐2) inhibitors. The compound crystallizes as a racemate. Linear hydrogen‐bonded chains are aligned along the [201] direction, and stacked π–π inter­actions and C—H⋯O contacts stabilize the crystal structure.     

Fuzzy implication operators for difference operations for fuzzy sets and cardinality-based measures of comparison

In this paper, we determine by means of fuzzy implication operators, two classes of difference operations for fuzzy sets and two classes of symmetric difference operations for fuzzy sets which preserve properties of the classical difference operation for crisp sets and the classical symmetric difference operation for crisp sets respectively. The obtained operations allow us to construct as in [B. De Baets, H. De Meyer, Transitivity-preserving fuzzification schemes for cardinality-based similarity measures, European Journal of Operational Research 160 (2005) 726–740], cardinality-based similarity measures which are reflexive, symmetric and transitive fuzzy relations and, to propose two classes of distances (metrics) which are fuzzy versions of the well-known distance of cardinality of the symmetric difference of crisp sets.     

Multistep and semibatch nitroxide‐mediated controlled free‐radical emulsion polymerization: A significant step toward conceivable industrial processes

Nitroxide‐mediated emulsion polymerizations of n‐butyl acrylate and styrene were performed with a monofunctional, water‐soluble alkoxyamine initiator and a difunctional one. Two different processes were applied, either in two steps or under semibatch conditions. In particular, the polymerization times were strongly reduced, while high conversions and good control over the polymer characteristics were maintained. In all cases, stable latexes were recovered; with the difunctional initiator in particular, they exhibited small particles and narrow particle size distributions. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 4142–4153, 2006     

Une approche formelle unifiée des théories de plaques et poutres linéairement élastiques

In this Note we present a formal scaling method that allows for the deduction from three-dimensional linearized elasticity of the equations of shearable structures such as Reissner–Mindlin's equations for plates and Timoshenko's equations for rods, as well as other models of thin structures. This method is based on the requirement that a scaled energy functional possibly including second-gradient terms stay bounded in the limit of vanishing ‘thinness’. To cite this article: B. Miara, P. Podio-Guidugli, C. R. Acad. Sci. Paris, Ser. I 343 (2006).     

7‐Nitro­indazole

The title compound, C₇H₅N₃O₂, is an inhibitor of nitric oxide synthase and mono­amine oxidase. The N1H tautomer crystallized as a dimer and adopts a planar conformation assisted by intramolecular hydrogen bonding.     

RAFT/MADIX copolymerization of vinyl acetate and 5,6‐benzo‐2‐methylene‐1,3‐dioxepane

The synthesis of well‐defined degradable poly(vinyl acetate) analogues is achieved by RAFT copolymerization of 5,6‐benzo‐2‐methylene‐1,3‐dioxepane (BMDO) and vinyl acetate (VAc) using methyl (ethoxycarbonothioyl)sulfanyl acetate (MEA) as controlling agent. Several monomer mixtures with low BMDO contents (<30 mol %) are employed to prepare different copolymers. In all the cases, the evolution of molar masses and the dispersity values (<1.26) confirm the controlled feature of the polymerization. The livingness of the obtained chains is demonstrated by successful chain extension experiments with VAc, although the presence of dead chains is also shown. The introduction of ester groups into the main chain of these P(VAc‐co‐BMDO) copolymers allows their degradation when treated with a mixture of KOH/MeOH in reflux during 2.5 h. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014 , 52, 104–111     

Studies on pyrrolidinones: Some attempts to improve the synthesis of methyl n‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (hei 81) by using n‐acyl iminium salts methodologies

Some ways to use the N‐acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl N‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3‐(3,4,5‐trimethoxyphenyl)dihydropy‐rrolo[1,2‐c]oxazole‐1,5‐dione).     

Points de Heegner et dérivées de fonctionsL p-adiques

Sans résumé     

Piezomaterials for bone regeneration design—homogenization approach

Relying on the piezoelectric properties of natural bone we propose a new biomaterial made of an inert perforated piezoelectric matrix filled with living osteoblast cells. We expect that this device will help the process of bone regeneration. In this paper we give some conceptual and numerical tools based on homogenization theory as a starting point in the design of such a “smart system”.     

Rational design of novel neurotensin mimetics: Discovery of a pharmacologically unprecedented agent exhibiting concentration-dependent dual effects as antagonist and full agonist

Summary We report the rational design of novel neurotensin mimetics through use of the Multiple Template Approach. This approach is based on our notion that a flexible peptide can be replaced by a partially flexible molecule, identified through testing a comparatively small number of molecules possessing a different intrinsic availability of conformations of the native peptide. The Multiple Template Approach has culminated in the discovery of a pharmacologically unprecedented agent, which behaves as a neurotensin antagonist at low concentration and as a full neurotensin agonist at high concentration.