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121.
Crecelius AC Cornett DS Caprioli RM Williams B Dawant BM Bodenheimer B 《Journal of the American Society for Mass Spectrometry》2005,16(7):1093-1099
We have developed a method to visualize matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI IMS) data aligned with optically determinable tissue structures in three dimensions. Details of the methodology are exemplified using the 3-D reconstruction of myelin basic protein (MBP) in the corpus callosum of a mouse brain. In this procedure, optical images obtained from serial coronal sections are first aligned to each other to reconstruct a surface of the corpus callosum from segmented contours of the aligned images. The MALDI IMS data are then coregistered to the optical images and superimposed into the surface to create the final 3-D visualization. Correlating proteomic data with anatomical structures provides a more comprehensive understanding of healthy and pathological brain functions, and holds promise to be utilized in more complex anatomical arrangements. 相似文献
122.
The first biomimetic synthesis of the yohimbine skeleton (7) from a Corynanthé-type precursor (2) is reported as well as the transformation of the latter into both the 19R and 19S heteroyohimbine series. Reactions were performed on an alumina surface. 相似文献
123.
A. Dondos und H. Benoit 《Colloid and polymer science》1978,256(7):725
Ohne Zusammenfassung 相似文献
124.
Below T2 = 202 K, in the incommensurate phase, a Debye relaxation appears for c33; it can be attributed to a linear coupling between an acoustical mode and a phason. The relaxation time is τ = τ0/(T0?T) with τ0 = 6.2 x 10?12 sec deg and T0 = 200.9 K. The same phenomenon appears more weakly for c11. The c66 elastic constant has a double discontinuity around T1 = 169 K; this shows that in the vicinity of T1 there are two transitions, separated by a temperature interval of 3°. 相似文献
125.
126.
Benoit Kloeckner 《Transformation Groups》2006,11(2):185-194
The group of direct isometries of the hyperbolic space
This isometric action admits many differentiable compactifications into an action on the closed n-dimensional ball. We prove
that all such compactifications are topologically conjugate but not necessarily differentiably conjugate. We give the classifications
of real analytic and smooth compactifications. 相似文献
127.
A. Benoit M. Chapellier G. Chardin L. Dumoulin K. Eitel J. Gascon G. Gerbier C. Goldbach J. Jochum A. de Lesquen G. Nollez F. Pröbst W. Seidel 《Physics letters. [Part B]》2006
The ZEPLIN Collaboration has recently published its first result presenting a maximum sensitivity of 1.1×10−6 picobarn for a WIMP mass of ≈60 GeV. The analysis is based on a discrimination method using the different time distribution of scintillation light generated in electron recoil and nuclear recoil interactions. We show that the methodology followed both for the calibration of the ZEPLIN-I detector response and for the estimation of the discrimination power is not reliable enough to claim any background discrimination at the present stage. The ZEPLIN-I sensitivity appears then to be in the order of 10−3 picobarn, three orders of magnitude above the claimed 1.1×10−6 picobarn. 相似文献
128.
Desjardins Benoit 《偏微分方程通讯》2013,38(11-12):1667-1703
129.
Habauzit D Armengaud J Roig B Chopineau J 《Analytical and bioanalytical chemistry》2008,390(3):873-883
Estrogenic compounds are a class of pharmaceutical products harmful to animals and a cause of environmental damage. The biological
activity of these compounds is high since they have been designed to act at low concentrations. Thus, even at the low concentrations
found in the environment, they may produce deleterious effects on aquatic organisms as well as on humans, who might be contaminated
in a number of ways (via drinking water or contaminated food, for example). We used the property of these compounds to bind
a specific protein (estrogen receptor, ER) to develop a quantification method of these chemical entities. Estrogenic compound
detection was performed using ER dimerization properties monitored by surface plasmon resonance (SPR). The ligand-activated
ER dimer was detected by its interaction with a specific DNA consensus sequence estrogen response element. The concentration
and the nature of the estrogenic compounds modified the SPR signal and were characteristic of the ligand-dependent homodimerization
of ER. For 17β-estradiol, dimerization of ER was experimentally determined at an ER to 17β-estradiol ratio near 1:1. Estrogenic
compounds (17β-estradiol, estriol, estrone, ethynyl estradiol) activated the dimerization process at different concentration
levels, while some others (tamoxiphen, resveratrol, genistein, bisphenol A) did not seem to have any effects on it. We demonstrated
that this method allows the direct detection of 17β-estradiol at concentrations above 1.4 μg/L (5 nM). 相似文献
130.
Adrian J Pinacho DG Granier B Diserens JM Sánchez-Baeza F Marco MP 《Analytical and bioanalytical chemistry》2008,391(5):1703-1712
A multianalyte ELISA has been developed for the simultaneous determination of the most frequently used antibiotic families in the veterinary field following the typical planar microarray configuration, where the identity of the target analyte is encoded by its location in the detection platform (Master et al. in Drug Discovery Today 11:1007-1011, 2006). To accomplish this aim, two individual enzyme-linked immunosorbent assays for sulfonamide and fluoroquinolone antibiotics and an enzyme-linked receptor assay for ss-lactam antibiotics have been combined. The strategy uses microplates coated with the corresponding haptenized proteins in specific sections of the microplate. The samples are mixed with a cocktail containing the bioreagents, and distributed in the wells of the microplate. Identification of the antibiotic present in a particular sample is consequently accomplished by detecting a positive response on the corresponding microplate section. Since the bioreceptors used show a wide recognition of the congeners of each antibiotic family, the multianalyte method is able to detect more than 25 different antibiotics from the three most important antibiotic families. The detectability reached in full-fat milk samples is below the European maximum residue limits. The accuracy and reliability of this multiplexed bioanalytical method have been demonstrated by analyzing blind spiked samples. 相似文献