Structure of the products of the metabolism of deoxypeganine and of deoxyvasicinone

The structures of the main components of the total metabolites of the anticholinesterase drug deoxypeganine (DOP) and its analog deoxyvasicinone (DOV) in the rat organism have been studied. The structures of two metabolites of DOP and DOV — 11-hydroxydeoxyvasicinone and 2-(-ethoxycarbonyl)ethyl-4-quinazoline — have been determined by the PMR method. On the basis of their structures and the results of measurements of the elementary compositions of ions, the fragmentation of the compounds has been elucidated. A minor component of the total metabolites has been isolated by chromato-mass spectrometry and for it the structure of 6-methoxydide-hydrovasicinone is proposed. A scheme of the metabolism of DOP and DOV has been put forward.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 758–766, November–December, 1983.     

Berberis alkaloids. XVII. Investigation of the alkaloids of Berberis heteropoda

The alkaloid composition of young shoots and leaves ofBerberis heteropoda Schrenk has been studied. In addition to known alkaloids, two new ones have been isolated — N-methyldihydroberberine and 8-oxoberberrubine, the structures of which were established by chemical transformations and a study of spectral properties. Of known alkaloids, berbamunine, aromoline, glaucine, thalicmidine, isocorydine, and reticuline have been found in this plant for the first time. Pseudopalmitine and laudanosine have been found for the first time in plants of the genusBerberis.Andizhan State Medical Institute. Institute of the Chemistry of Plant Substances of Uzbek Republic Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 53–59, January–February, 1993.     

A study of the pectins of wild apples

Pectins have been isolated from five species of wild apples and have been characterized. They contain galacturonic acid, galactose, glucose, and arabinose residues. The titrimetric indices of the substances isolated have been determined. It has been shown by IR spectroscopy the pectins isolated are extracted partially in the form of pectic acids.     

Seed oil ofCousinia severzovii

The composition of the seed oil ofCousinia severzovii has been studied; about 20 types and classes of compounds were isolated from the oil, including 6% of triterpenes with a molecular weight of 426 in the free state, as the acetylated derivatives, and as derivatives acylated with higher fatty acids of the 34:0–13:0 group in a ratio of 1:1:2, respectively; and 3.8% of oxidized acylglycerols (seven types). The classes of lipids were represented by no individual compound but only by a series of homologs or isomers.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 38–44, January–February, 1981.     

Germacranolide fromTanacetopsis mucronata

A sesquiterpene lactone of the germacrane series, mucrochin, has been isolated from the epigeal part ofTanacetopsis mucronata, and its structure has been studied by IR and mass spectral methods and PMR spectroscopy. It structure has been determined unambiguously by x-ray structural analysis as 5,6-dihydroxy-5α,6β,7α,8β(H)-germacra-1(10),4(15) 1(13)-trien-8,12-olide. A boat-chair conformation with a configuration of the₁D¹⁴ ₁₅D₅ type has been established. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 492–498, July–August, 1998.     

Phlomoside D — an iridoid glycoside fromPhlomis regelii

A new iridoid – phlomoside D- has been isolated from the epigeal organs ofPhlomis regelii (M. Pop). Its structure has been established on the basis of chemical transformations and spectral characteristics.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 89 14 75. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 551–553, July–August, 1996. Original article submitted February 5, 1996.     

Essential Oil from the Aerial Part of Saponaria griffithiana and S. officinalis

Chemistry of Natural Compounds -