Synthesis,crystallographic and spectroscopic studies,evaluation as antimicrobial and cytotoxic agents of a novel mixed-ligand nickel(II) complex

A new mononuclear mixed-ligand complex of Ni(II) has been synthesized and structurally characterized by single-crystal X-ray diffraction as [Ni(4-Cl-pydc)(apym)(H₂O)₂], where 4-Cl-pydc and apym are 4-chloropyridine-26-dicarboxylate and 2-aminopyrimidine, respectively. Spectroscopic studies such as FT-IR, UV-vis, ¹H-NMR, and thermal analysis (TGA/DTA) were carried out. The fluorescence properties were studied in solvents with different dipole moments. Antimicrobial activities of 4-chloropyridine-26-dicarboxylic acid (1), 2-aminopyrimidine (2), complex (3), and nickel(II) nitrate hexahydrate (4) were investigated by disk diffusion and broth microdilution methods against three Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis, Staphylococcus epidermidis and three Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa, S. marcescens; also antifungal effect was evaluated on Aspergillus niger and Saccharomyces cerevisiae in vitro. The highest antibacterial activity of complex was observed nearly equal to gentamicin as a standard drug toward S. epidermids with IZD of 18 mm. The in vitro antiproliferative activity of 1–4 on H1299 (a human non-small cell lung carcinoma), HepG2 (a human liver hepatocellular carcinoma), and β-TC3 (a mouse beta pancreatic) cell lines was evaluated by MTT (3-(45-dimethylthiazol-2-yl)-25-diphenyl-2H-tetrazolium bromide) assay and, effect of complex on depolarization of mitochondrial membrane (MMP) of all three cell lines was measured by rhodamine 123. The highest cytotoxic effect of complex was exhibited toward H1299 cell line with IC₅₀ value equal to 10 μM.     

Weak module amenability of triangular Banach algebras

Let A and B be unital Banach algebras and let M be a unital Banach A,B-module. Forrest and Marcoux [6] have studied the weak amenability of triangular Banach algebra \(\mathcal{T} = \left[ {_B^{AM} } \right]\) and showed that T is weakly amenable if and only if the corner algebras A and B are weakly amenable. When \(\mathfrak{A}\) is a Banach algebra and A and B are Banach \(\mathfrak{A}\)-module with compatible actions, and M is a commutative left Banach \(\mathfrak{A}\)-A-module and right Banach \(\mathfrak{A}\)-B-module, we show that A and B are weakly \(\mathfrak{A}\)-module amenable if and only if triangular Banach algebra T is weakly \(\mathfrak{T}\)-module amenable, where \(\mathfrak{T}: = \{ [^\alpha _\alpha ]:\alpha \in \mathfrak{A}\} \).     

Pseudo-amenability of certain semigroup algebras

In this paper, we investigate the pseudo-amenability of semigroup algebra ? ¹(S), where S is an inverse semigroup with uniformly locally finite idempotent set. In particular, we show that for a Brandt semigroup \(S={\mathcal{M}}^{0}(G,I)\), the pseudo-amenability of ? ¹(S) is equivalent to the amenability of G.     

Transshipment games with identical newsvendors and cooperation costs

In a transshipment game, supply chain agents cooperate to transship surplus products. Although the game has been well studied in the OR literature, the fundamental question whether the agents can afford cooperation costs to set up and maintain the game in the first place has not been addressed thus far. This paper addresses this question for the cooperative transshipment games with identical agents having normally distributed independent demands. We provide characterization of equal allocations which are in the core of symmetric games, and prove that not all transshipment games are convex. In particular, we prove that though individual allocations grow with the coalition size, the growth diminishes according to two rules of diminishing individual allocations. These results are the basis for studying the games with cooperation costs. We model the cooperation costs by the cooperation network topology and the cooperation cost per network link. We consider two network topologies, the clique and the hub, and prove bounds for the cost per link that render coalitions stable. These bounds always limit coalition size for cliques. However, the opposite is shown for hubs, namely newsvendors can afford cooperation costs only if their coalition is sufficiently large.     

Aromatization of Hantzsch Ester 1,4‐Dihydropyridines with Iodine under Normal Conditions and Ultrasound Irradiation

A variety of Hantzsch ester 1,4‐dihydropyridines are efficiently oxidized to their corresponding pyridine compounds with iodine under normal conditions and ultrasound irradiation. The reactions were carried out in refluxing CH₃CN.     

A Novel Electrochemiluminesence Sensor Based on Silver Prussian Blue Analogue/Carboxylated Sulfur-doped Graphitic Carbon Nitride Nanocomposite for Determination of Lamotrigine

In this study, for the first time an electrochemiluminescence sensor for ultra-trace monitoring of lamotrigine is reported. The sensing probe was fabricated using silver prussian blue analogue as a new effective co-reaction accelerator and carboxylated sulfur-doped graphitic carbon nitride nanocomposite as a new green luminophore. Also potassium peroxydisulfate was utilized as a strong co-reactant. The proposed ECL sensor exhibited excellent wide linear range (3.45×10⁻¹⁵ to 2.98×10⁻⁸ M), low detection limit (4.89×10⁻¹⁶ M), the relative standard deviation of 1.07 %, outstanding reproducibility and superior long-term stability. The prominent advantages of the sensor showed that it can be used to determine LMT in clinical samples.     

Response surface analysis for understanding the effects of synthesis parameters on the microstructure of hyperbranched polyesters

Synthesis parameters including the time of condensation reaction, the monomer-to-core ratio (2, 2-bis (hydroxymethyl) propionic acid) (pseudo-generation) and the type of catalyst were changed methodically to investigate their effects on the microstructure of resulting hyperbranched polyesters (HBPEs). Response surface methodology (RSM) was utilized to uncover the relationship between changing variables and the number of terminal hydroxyl groups of HBPSs by which the individual and interactive effects of the aforementioned synthesis parameters were explored. The degree of branching and molecular weight of the HBPEs were evaluated by titration of hydroxyl number and gel permeation chromatography, respectively. Fourier transform infrared spectroscopy and nuclear magnetic resonance analyses confirmed attachment of functional groups to the molecules. Interpretations based on RSM showed that increase of the number of the core molecules, which is equivalent To reduction of the pseudo-generation, narrows the molecular weight distribution of the prepared hyperbranched polyester; so that the lowest molecular weight distribution is obtained for the first pseudo-generation HBPEs with the monomer-to-core ratio of 3:1 and the average number of the terminal hydroxyl groups in between 6 and 8. The samples prepared by the sulfuric acid catalyst had the highest average number of terminal hydroxyl groups, at the same time narrowest molecular weight distribution.     

A simple and rapid flow-injection chemiluminescence method for the determination of noscapine with Ru(phen)3(2+)-Ce(IV) system

A new flow injection chemiluminescence (CL) system was used for the determination of noscapine. This technique is based on the reduction effect of noscapine on the Ru(phen)3(3+), which is produced by reaction between Ru(phen)3(2+) and acidic Ce(IV) solutions, and this rapid reduction produces strong CL. Calibration plots were linear over the range of 3.0 x 10(-7) - 2.0 x 10(-6) mol L(-1) and 2.0 x 10(-6) - 2.0 x 10(-4) mol L(-1). The CL intensity was so high, that it is able to produce a detection limit of 6.6 x 10(-8) M noscapine (3sigma). The relative standard deviation of 2.0 x 10(-6) M noscapine was 1.0% (n=10). The proposed method was successfully applied for the flow injection determination of noscapine in cough and Tonin syrup samples. The results of real sample analyses show good recovery percentages (97.3-102.4%). The minimum sampling rate was 100 samples per hour.