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91.
Synthesis,Antiproliferative, and c‐Src Kinase Inhibitory Activities of 4‐Oxo‐4H‐1‐benzopyran Derivatives 下载免费PDF全文
Karam Chand Rakesh K Tiwari Sumit Kumar Amir Nasrolahi Shirazi Sweta Sharma Erik V Van der Eycken Virinder S Parmar Keykavous Parang Sunil K Sharma 《Journal of heterocyclic chemistry》2015,52(2):562-572
A new class of 4‐oxo‐4H‐1‐benzopyran derivatives were synthesized and their antiproliferative activity examined against a panel of three human cancer cell lines, that is, breast carcinoma (MDA‐MB‐468), ovarian adenocarcinoma (SK‐OV‐3), and colorectal adenocarcinoma (HT‐29). Two compounds, that is, 3‐hexyl‐7,8‐dihydroxy‐4‐oxo‐4H‐1‐benzopyran and (E)‐ethyl 3‐(7‐methoxy‐4‐oxo‐4H‐1‐benzopyran‐3‐yl)acrylate were found to be potent against all three cancer cell lines studied at 50 μM concentration. Also, the inhibitory potency of the compounds was evaluated against active Src kinase. A few of these compounds exhibited modest Src kinase inhibitory activity (IC50 = 52–57 μM). Structure‐activity relationship studies with respect to the nature and position of substituents on the lead compounds could be further exploited for the design and development of more potent antiproliferative agents and/or Src kinase inhibitors. 相似文献
92.
A mild, efficient, and selective protocol for the one-pot $N$ -alkylation of sulfonamides with alcohols using triphenylphosphine and carbon tetrachloride is described. In this method, treatment of alcohols with a mixture of triphenylphosphine, carbon tetrachloride, and potassium sulfonylamide salts in refluxing anhydrous DMF furnishes the corresponding $N$ -alkyl sulfonamides in good to excellent yields. This protocol is highly efficient for various structurally diverse alcohols and potassium sulfonylamide salts. In this paper the influence of solvents and various reagents as sources for electrophilic-halogen instead of carbon tetrachloride in combination with triphenylphosphine have been examined. This protocol demonstrates the selectivity between primary and secondary alcohols. A plausible mechanism for this protocol has been described. 相似文献
93.
A financial market is an example of an adaptive complex network consisting of many interacting units. This network reflects market’s behavior. In this paper, we use Random Matrix Theory (RMT) notion for specifying the largest eigenvector of correlation matrix as the market mode of stock network. For a better risk management, we clean the correlation matrix by removing the market mode from data and then construct this matrix based on the residuals. We show that this technique has an important effect on correlation coefficient distribution by applying it for Dow Jones Industrial Average (DJIA). To study the topological structure of a network we apply the removing market mode technique and the threshold method to Tehran Stock Exchange (TSE) as an example. We show that this network follows a power-law model in certain intervals. We also show the behavior of clustering coefficients and component numbers of this network for different thresholds. These outputs are useful for both theoretical and practical purposes such as asset allocation and risk management. 相似文献
94.
Leal C Ewert KK Shirazi RS Bouxsein NF Safinya CR 《Langmuir : the ACS journal of surfaces and colloids》2011,27(12):7691-7697
The self-assembly of a custom-synthesized pentavalent cationic lipid (MVL5) and glycerol monooleate (GMO) with small interfering RNA (siRNA) results in the formation of a double-gyroid bicontinuous inverted cubic phase with colocalized lipid/siRNA domains as shown by synchrotron X-ray scattering and fluorescence microscopy. The high charge density (due to MVL5) and positive Gaussian modulus of the GMO-containing membranes confer optimal electrostatic and elastic properties for endosomal escape, enabling efficient siRNA delivery and effective, specific gene silencing. 相似文献
95.
Kourosh Nozari Nooshin Behrouz Ahmad Sheykhi 《International Journal of Theoretical Physics》2013,52(7):2351-2362
We investigate thermodynamics of viscous dark energy interacting with dark matter in a DGP braneworld. We show that the Friedmann equation in this setup can be rewritten as the first law of thermodynamics on the apparent horizon. We study the time evolution of the total entropy including the entropy of the matter fields inside the apparent horizon together with the entropy associated with the apparent horizon. Interestingly enough, we find that, in the presence of bulk viscosity, the generalized second law of thermodynamics is always preserved for both branches of the DGP braneworld. When the time varying gravitational constant is taken into account, the generalized second law of thermodynamics can be secured provided $\dot{G}_{4}<0$ , $\frac{\dot{G}_{5}}{G_{5}}>\frac{\dot{G}_{4}}{G_{4}}$ and $\omega_{de}>-1-u+\frac{3H\xi}{\rho_{de}}$ , where ξ and u are, respectively, the bulk viscosity coefficient and the energy densities ratio of the two dark components on the brane. 相似文献
96.
In this paper, we first extend the dual simplex method to a type of fuzzy linear programming problem involving symmetric trapezoidal fuzzy numbers. The results obtained lead to a solution for fuzzy linear programming problems that does not require their conversion into crisp linear programming problems. We then study the ranges of values we can achieve so that when changes to the data of the problem are introduced, the fuzzy optimal solution remains invariant. Finally, we obtain the optimal value function with fuzzy coefficients in each case, and the results are described by means of numerical examples. 相似文献
97.
An experimental study performed to compare the results of different methods used in the literature for the calculation of heat transfer coefficient in double-tube heat exchangers. Then, a new fundamental approach was proposed which used the temperature profile and the local heat transfer coefficients. In this method, the heat transfer coefficient has been calculated for the total length of the heat exchanger including developing and fully developed regions. Numerous experimentations have been conducted in a double-tube heat exchanger. A significant difference observed between the results obtained from the suggested approach and those of the previous methods. 相似文献
98.
The effect of the addition of polymeric drag reducing agent on water flow heat transfer and pressure drop was studied experimentally. Polyacrylamide (PAM) aqueous solutions at different concentrations (up to 100 ppm) at fully developed turbulent flow were used in a double tube heat exchanger. In contrast to previous studies, drag reduction due to using PAM was negligible. The addition of PAM, even at low concentrations, caused significant reduction in heat transfer. Results showed that increasing PAM concentration lowered the amount of heat transfer. Maximum heat transfer reduction of 25% occurred at the concentration of 100 ppm for PAM aqueous solution. 相似文献
99.
A new linear cavity BEFL configuration for increased Stokes-line generation is proposed and demonstrated utilizing a 2 × 2 coupler at the end of the linear cavity. The proposed linear cavity is able to generate up to 33 Stokes lines in the 1590-nm region at a channel spacing of 0.089 nm. The Stokes lines are generated at a BP power of 4 dBm and a 1480-nm pump power of 100 mW. The number of Stokes generated by the proposed BELF is higher compared to conventional BEFL configurations in which the 2 × 2 coupler is placed in the middle of the linear cavity. The number of Stokes lines generated is observed to depend on the 1480-nm pump power as well as the operating wavelength region, which must be as close as possible to the lasing bandwidth of the free-running BEFL. The proposed multiwavelength BEFL is able to operate stably at room temperatures and is also compact due to the use of a 215-cm bismuth-based EDF as the linear gain medium. 相似文献
100.
A novel calix[4]arene derivative with two ferrocenyl Schiff-base groups at the upper rim 3 has been synthesized from 5,17-diformyl-25,27-dipropoxy-26,28-dihydroxy calix[4]arene and 4-ferrocenylaniline via condensation reaction. Reduction of 3 with sodium borohydride led to calix[4]arene derivative 4 with two amino ferrocenyl groups at the upper rim. The ferrocenyl Schiff-base calix[4]arene and its corresponding reduced amine have been purified and characterized by elemental analysis,1H NMR, FTIR, Mass and UV-vis spectral data. Electrochemical properties of compounds 3 and 4 have been investigated. Cyclic voltammograms of 3 and 4 show reversible redox couples of ferrocene/ferrocinium at E1/2=0.401 V and 0.346 V, respectively. Electrochemical studies show these redox active compounds electrochemically recognize trivalent lanthanides La3+ and Ce3+ and divalent Pb2+ and Cu2+cations. With ferrocenyl Schiff-base calix[4]arene 3 an anodic shift as large as 130 mV is observed on addition of one equivalent of Ce3+ ion. Also extraction properties of compound 4 towards some metal cations have been described. It has been observed that compound 4 has a good selectivity for metal cations Fe3+, Cu2+, Pb2+ and Cd2+ against Ni2+ and Co2+. 相似文献