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11.
Aaltonen T Álvarez González B Amerio S Amidei D Anastassov A Annovi A Antos J Apollinari G Appel JA Apresyan A Arisawa T Artikov A Asaadi J Ashmanskas W Auerbach B Aurisano A Azfar F Badgett W Barbaro-Galtieri A Barnes VE Barnett BA Barria P Bartos P Bauce M Bauer G Bedeschi F Beecher D Behari S Bellettini G Bellinger J Benjamin D Beretvas A Bhatti A Binkley M Bisello D Bizjak I Bland KR Blocker C Blumenfeld B Bocci A Bodek A Bortoletto D Boudreau J Boveia A Brau B Brigliadori L Brisuda A 《Physical review letters》2010,105(23):232003
We present a measurement of the top-quark width in the lepton+jets decay channel of tt events produced in p p collisions at Fermilab's Tevatron collider and collected by the CDF II detector. From a data sample corresponding to 4.3 fb(-1) of integrated luminosity, we identify 756 candidate events. The top-quark mass and the mass of the hadronically decaying W boson that comes from the top-quark decay are reconstructed for each event and compared with templates of different top-quark widths (Γ(t)) and deviations from nominal jet energy scale (Δ(JES)) to perform a simultaneous fit for both parameters, where Δ(JES) is used for the in situ calibration of the jet energy scale. By applying a Feldman-Cousins approach, we establish an upper limit at 95% confidence level (CL) of Γ(t) <7.6 GeV and a two-sided 68% CL interval of 0.3 GeV <Γ(t) <4.4 GeV for a top-quark mass of 172.5 GeV/c(2), which are consistent with the standard model prediction. 相似文献
12.
Ioannis Zalachoras Gwendolynn Grootaers Lisa TCM van Weert Yves Aubert Suzanne R de Kreij Nicole A Datson Willeke MC van Roon-Mom Annemieke Aartsma-Rus Onno C Meijer 《BMC neuroscience》2013,14(1):1-12
Background
Antisense oligonucleotide (AON)-mediated exon skipping is a powerful tool to manipulate gene expression. In the present study we investigated the potential of exon skipping by local injection in the central nucleus of the amygdala (CeA) of the mouse brain. As proof of principle we targeted the splicing of steroid receptor coactivator-1 (SRC-1), a protein involved in nuclear receptor function. This nuclear receptor coregulator exists in two splice variants (SRC-1a and SRC-1e) which display differential distribution and opposing activities in the brain, and whose mRNAs differ in a single SRC-1e specific exon.Methods
For proof of principle of feasibility, we used immunofluorescent stainings to study uptake by different cell types, translocation to the nucleus and potential immunostimulatory effects at different time points after a local injection in the CeA of the mouse brain of a control AON targeting human dystrophin with no targets in the murine brain. To evaluate efficacy we designed an AON targeting the SRC-1e-specific exon and with qPCR analysis we measured the expression ratio of the two splice variants.Results
We found that AONs were taken up by corticotropin releasing hormone expressing neurons and other cells in the CeA, and translocated into the cell nucleus. Immune responses after AON injection were comparable to those after sterile saline injection. A successful shift of the naturally occurring SRC-1a:SRC-1e expression ratio in favor of SRC-1a was observed, without changes in total SRC-1 expression.Conclusions
We provide a proof of concept for local neuropharmacological use of exon skipping by manipulating the expression ratio of the two splice variants of SRC-1, which may be used to study nuclear receptor function in specific brain circuits. We established that exon skipping after local injection in the brain is a versatile and useful tool for the manipulation of splice variants for numerous genes that are relevant for brain function. 相似文献13.
KM Varier AM Vinodkumar NVSV Prasad PV Madhusudhana Rao DL Sastry Lagy T Baby MC Radhakrishna NG Puttaswamy JJ Das P Sugathan N Madhavan AK Sinha DO Kataria 《Pramana》1999,53(3):529-533
Large enhancements have been observed in the sub-barrier fusion cross sections for Ti+Ni systems in our previous studies.
Coupled channel calculations incorporating couplings to 2+ and 3− states failed to explain these enhancements completely. A possibilty of transfer channels contributing to the residual enhancements
had been suggested. In order to investigate the role of relevant transfer channels, measurements of one- and two-nucleon transfer
were carried out for 46,48Ti+61Ni systems. The present paper gives the results of these studies. 相似文献
14.
Aaltonen T Alvarez González B Amerio S Amidei D Anastassov A Annovi A Antos J Apollinari G Appel JA Apresyan A Arisawa T Artikov A Asaadi J Ashmanskas W Auerbach B Aurisano A Azfar F Badgett W Barbaro-Galtieri A Barnes VE Barnett BA Barria P Bartos P Bauce M Bauer G Bedeschi F Beecher D Behari S Bellettini G Bellinger J Benjamin D Beretvas A Bhatti A Binkley M Bisello D Bizjak I Bland KR Blumenfeld B Bocci A Bodek A Bortoletto D Boudreau J Boveia A Brigliadori L Brisuda A Bromberg C Brucken E 《Physical review letters》2012,108(1):011801
A search for a narrow Higgs boson resonance in the diphoton mass spectrum is presented based on data corresponding to 7.0 fb{-1} of integrated luminosity from pp collisions at sqrt[s]=1.96 TeV collected by the CDF experiment. No evidence of such a resonance is observed, and upper limits are set on the cross section times branching ratio of the resonant state as a function of Higgs boson mass. The limits are interpreted in the context of the standard model and one fermiophobic benchmark model where the data exclude fermiophobic Higgs bosons with masses below 114 GeV/c{2} at a 95% Bayesian credibility level. 相似文献
15.
Aaltonen T Álvarez González B Amerio S Amidei D Anastassov A Annovi A Antos J Apollinari G Appel JA Arisawa T Artikov A Asaadi J Ashmanskas W Auerbach B Aurisano A Azfar F Badgett W Bae T Barbaro-Galtieri A Barnes VE Barnett BA Barria P Bartos P Bauce M Bedeschi F Beecher D Behari S Bellettini G Bellinger J Benjamin D Beretvas A Bhatti A Binkley M Bisello D Bizjak I Bland KR Blumenfeld B Bocci A Bodek A Bortoletto D Boudreau J Boveia A Brigliadori L Bromberg C Brucken E Budagov J Budd HS 《Physical review letters》2012,108(15):151803
We have measured the W-boson mass M(W) using data corresponding to 2.2 fb(-1) of integrated luminosity collected in pp collisions at sqrt[s] = 1.96 TeV with the CDF II detector at the Fermilab Tevatron collider. Samples consisting of 470,126 W → eν candidates and 624,708 W → μν candidates yield the measurement M(W) = 80,387 ± 12(stat.) ± 15(syst.) = 80,387 ± 19 MeV/c2. This is the most precise measurement of the W-boson mass to date and significantly exceeds the precision of all previous measurements combined. 相似文献
16.
Bolus shapes for injected samples have been calculated for times of interest in experiments on flow injection analysis. The effect of both system and molecular parameters on the shapes and the dispersion of samples is considered. The implications for merging-zone experiments are discussed briefly. 相似文献
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