基于ICP－MS截尾数据与支持向量机优化模型鉴别蜂蜜植物源

该文开展了一种电感耦合等离子体质谱(ICP－MS)截尾数据和支持向量机(SVM)分类模型识别蜂蜜植物源的研究.实验选取荆条蜜、洋槐蜜、葵花蜜、油菜蜜4种不同植物源的蜂蜜共97例,经微波消解等预处理后,采用ICP-MS分别测得蜂蜜样品中16种金属元素的含量,并研究13种具有显著性差异的金属元素,以含截尾数据和不含截尾数据...     

CO2相干激光轮廓成像研究

本文以自制CO_2相干激光成像的实验系统,成功地实现了相干激光的彩色轮廓成像。     

关于△=4的满图猜想

研究了著名的满图猜想,利用反证的方法,证明了△=4时,满图猜想是成立的.     

五味子治疗大鼠糖尿病肾病作用机制的血清代谢组学研究

采用基于超高效液相色谱与串联四级杆飞行时间质谱仪(Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry,UPLC/Q-TOF-MS)联用技术的代谢组学方法,通过分析大鼠血清内源性代谢物的变化,研究五味子治疗糖尿病肾病的作用机制。利用高脂高糖饲料喂养并腹腔注射链脲佐菌素(STZ)建立糖尿病大鼠模型。给药12周后,采用试剂盒方法测定尿蛋白、尿肌酐的含量,结果表明五味子水提取物可以显著降低模型动物的尿蛋白含量(p<0.05),对糖尿病大鼠肾病并发症具有一定的改善作用。采用UPLC/Q-TOF-MS方法分析了五味子对糖尿病肾病大鼠的血清代谢轮廓,分析了健康组、模型组和五味子给药组的大鼠血清,采用偏最小二乘法-判别分析(Partial least squares discriminant analysis,PLS-DA)进行数据分析。PLS-DA得分图显示健康组、模型组和五味子组的代谢轮廓有显著差别,根据正交偏最小二乘法-判别分析(Orthogonal partial least squares discriminant analysis,OPLS-DA)载荷图筛选,将对各组分离贡献大的化合物的串联质谱分析数据,经Human Metabolome Database(HMDB)等数据库检索,进行质谱信息匹配,鉴定出黄尿酸、油酰胺、棕榈酰胺、尿酸、5-羟基己酸、硫酸对甲酚、对甲酚葡萄糖苷酸7种内源性代谢物为生物标记物。研究结果表明五味子通过影响色氨酸代谢、嘌呤代谢、肠内菌代谢、脂肪酸代谢等通路对糖尿病肾病发挥治疗作用,其中嘌呤代谢、肠内菌代谢通路可能是五味子发挥治疗作用的重要途径。     

Fractional Moments of Automorphic L-Functions on GL（m）

Let π be an irreducible unitary cuspidal representation of GLm(AQ), m ≥ 2. Assume that π is self-contragredient. The author gets upper and lower bounds of the same order for fractional moments of automorphic L-function L(s, π) on the critical line under Generalized Ramanujan Conjecture; the upper bound being conditionally subject to the truth of Generalized Riemann Hypothesis.     

关于图的反符号圈控制数

本文研究了图的反符号圈控制的问题.利用分类和反证的方法,获得了满足反符号圈控制数为负边数加4的连通图的刻画和完全二部分图的反符号圈控制数.     

Modelling methyl tertiary butyl ether and tertiary butyl alcohol biodegradation by a bacterial consortium

The widespread use of methyl tertiary butyl ether (MTBE) as an additive in gasoline has resulted in serious soil and groundwater pollution. To tackle MTBE contamination in groundwater, bioremediation is considered a cost-effective and energy-efficient option. The design of an efficient, reliable and reproducible bioremediation strategy requires a thorough understanding of the (microbial) degradation kinetics of both MTBE and tertiary butyl alcohol (TBA), that is, the main intermediate during bioremediation of MTBE. To assist the design procedure, this research focuses on building a mathematical model to describe MTBE/TBA degradation kinetics by a bacterial consortium, that is, the VITO M-consortium.

For the presented case study, the information obtained from experimental data is combined with knowledge regarding the biodegradation reactions in order to obtain a low-complexity, accurate mathematical model. The resulting model accurately describes MTBE/TBA degradation and has successfully been validated on independent experimental data. Since the model is of the mass balance type, it can easily be extended to other types of operation by defining the transport terms of the new system. This makes the model a very useful tool in the design procedure for large-scale bioremediation strategies. Furthermore, the model provides insight into the MTBE/TBA degradation kinetics and biodegradation mechanisms by hypothesis testing.     

Compton 散射对线偏光在相对论等离子体中调制不稳定性的影响

应用多光子非线性Compton 散射模型、电磁波非线性色散方程和Karpman 方法,研究了 Compton 散射对线偏光在相对论等离子体中调制不稳定性的影响,给出了等离子体的非线性色散、控制和调制不稳定性增 长率的修正方程,并进行了数值模拟。结果表明：与散射前相比,随无量纲化频率值减小,即趋于等离子体临界面处,散射使相同扰动波数引起的调制不稳定性增长率更大,使等离子体临界面处的调制不稳定性增长率较其余位置尤为显著。这是由于散射光使等离子体非线性增强,形成了激光场自聚焦和自成丝的缘故。     

UPLC-MS/MS结合多探针底物方法研究刺五加叶中黄酮苷类成分对CYP450活性的影响

利用超高效液相色谱-串联质谱联用(UPLC-MS/MS)的多反应监测(MRM)技术结合多探针底物方法, 研究了刺五加叶中的主要黄酮苷类化合物槲皮苷、金丝桃苷及芦丁对肝细胞色素P450酶(CYP450)亚型CYP1A2, CYP2C, CYP2E1, CYP2D和CYP3A活性的影响. 结果表明, 3种化合物对各CYP亚型酶均有抑制作用, 其中金丝桃苷和槲皮苷对CYP1A2催化的非那西丁的O-脱乙基反应抑制的IC₅₀值分别为46.53和49.75 μmol/L, 金丝桃苷和芦丁对CYP2E1催化的氯唑沙宗的6-羟基化反应抑制的IC₅₀值分别为99.87和86.36 μmol/L. 机理性抑制实验结果表明, 3种化合物对2种亚型酶的抑制作用是随着预孵时间延长而增强的机理性抑制.     

氨改性二氧化钛的制备及可见光催化性能研究

以工业TiO2为原料,在不同氨气浓度下采用热处理法制备了N掺杂的光催化剂.用XRD,TEM,XPS,UV-visDRS和PL等对其结构进行了表征,以亚甲基蓝为目标化合物,评价了其可见光催化活性.结果表明,当氨气浓度为99;时,工业TiO2在500℃下煅烧3h后,具有优良的可见光催化活性,对亚甲基蓝的去除率达到93;.当煅烧温度升高到600℃后,TiO2的晶相由锐钛矿向金红石转变,随着煅烧过程中氨气浓度的增加,所制备的催化剂对亚甲基蓝的降解显著增加.