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排序方式: 共有1441条查询结果,搜索用时 264 毫秒
31.
Sumon Basak Subhabrata Dutta Prof. Dr. Debabrata Maiti 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(41):10533-10557
The skeletal presence of 1,3-azoles in a variety of bioactive natural products, pharmacophores, and organic materials demands the derivatization of such heteroarenes regioselectively. Plenty of cross-coupling as well as cyclocondensation reactions have been performed to build up these skeletons but remained commercially unrealizable. A couple of severe drawbacks are faced by these traditional protocols that require a more straightforward strategy to obviate them. Transition metal-catalyzed C−H functionalization has emerged as a superior alternative in that context. 1,3-Azoles and their benzo counterparts have been extensively functionalized exploiting both noble and earth-abundant transition metals. Lately, C-2 functionalization have gained much traction due to the ease of attaining high regioselectivity and installation of synthetically manipulative functionalities. This critical review presents a bird‘s eye view of all major C-2 functionalization of (benz)azoles catalyzed by a diverse set of metals performed over the past 15 years. 相似文献
32.
Ewa Grela Michael Stich Amit K Chattopadhyay 《The European Physical Journal B - Condensed Matter and Complex Systems》2018,91(11):267
This is an epidemiological SIRV model based study that is designed to analyze the impact of vaccination in containing infection spread, in a 4-tiered population compartment comprised of susceptible, infected, recovered and vaccinated agents. While many models assume a lifelong protection through vaccination, we focus on the impact of waning immunization due to conversion of vaccinated and recovered agents back to susceptible ones. Two asymptotic states exist, the “disease-free equilibrium” and the “endemic equilibrium” and we express the transitions between these states as function of the vaccination and conversion rates and using the basic reproduction number. We find that the vaccination of newborns and adults have different consequences on controlling an epidemic. Also, a decaying disease protection within the recovered sub-population is not sufficient to trigger an epidemic at the linear level. We perform simulations for a parameter set mimicking a disease with waning immunization like pertussis. For a diffusively coupled population, a transition to the endemic state can proceed via the propagation of a traveling infection wave, described successfully within a Fisher-Kolmogorov framework. 相似文献
33.
Premchand B. Shelke Suraj N. Mali Hemchandra K. Chaudhari Amit P. Pratap 《Journal of heterocyclic chemistry》2019,56(11):3048-3054
Chitosan hydrochloride as biopolymer‐based, renewable, and recyclable heterogeneous catalyst was used for efficient one‐pot synthesis of perimidine derivatives. This newly developed greener methodology provides a very simple and greener route for the synthesis of perimidines in short time with excellent yield. 相似文献
34.
Priyanka Lohar Manish Kumar Sharma Amit Kumar Sahu Rajeswari Rathod Pinaki Sengupta 《Biomedical chromatography : BMC》2019,33(12)
The combination of acebrophylline (ABP), levocetirizine (LCZ) and pranlukast (PRN) is used to treat allergic rhinitis, asthma, hay‐fever and other conditions where patients experience difficulty in breathing. This study was carried out with the aim of developing and validating a reverse‐phase high‐performance liquid chromatographic bioanalytical method to simultaneously quantitate ABP, LCZ and PRN in rat plasma. The objective also includes determination of the pharmacokinetic interaction of these three drugs after administration via the oral route after individual and combination treatment in rat. Optimum resolution between the analytes was observed with a C18 Kinetex column (250 mm × 4.6 mm × 5 μm). The chromatography was performed in a gradient elution mode with a 1 mL/min flow rate. The calibration curves were linear over the concentration range of 100–1600 ng/mL. The intra‐ and inter‐day precision and accuracy were found to be within acceptable limits as specified in US Food and Drug Administration guideline for bioanalytical method validation. The analytes were stable on the bench‐top (8 h), after three freeze–thaw cycles, in the autosampler (8 h) and as a dry extract (?80°C for 48 h). The statistical results of the pharmacokinetic study in Sprague–Dawley rats showed a significant change in pharmacokinetic parameters for PRN upon co‐administration of the three drugs. 相似文献
35.
36.
Rajan Katoch Amit Sethi Neelam Thakur Larry L. Murdock 《Applied biochemistry and biotechnology》2013,171(4):847-873
The research on the RNA interference (RNAi) for the control of insect pests has made significant growth in recent years. The availability of the genomic sequences of insects has further widened the horizons for the testing of this technology to various insect groups. Different modes of application of double-stranded RNA (dsRNA) have been tested; however, the practicability of delivery of dsRNA in insects still remains the biggest challenge. Till date, the oral delivery of dsRNA in insects is one of the efficient approaches for the practical application of this technique. The uptake of dsRNA from the insect gut is mediated either by SID-1/SID-2 transmembrane proteins or by endocytosis; however, the systemic RNAi machinery still remains to be revealed in insect species. The RNAi-mediated gene knockdown has shown striking results in different insect groups, pointing it to be the upcoming technique for insect control. However, before the successful application of this technique for insect control, some potential issues need to be resolved. This review presents the account of prospects and challenges for the use of this technology for insect control. 相似文献
37.
To the best of our knowledge, there is no method in literature for solving such fully fuzzy linear programming (FLP) problems in which some or all the parameters are represented by unrestricted L-R flat fuzzy numbers. Also, to propose such a method, there is need to find the product of unrestricted L-R flat fuzzy numbers. However, there is no method in the literature to find the product of unrestricted L-R flat fuzzy numbers.In this paper, firstly the product of unrestricted L-R flat fuzzy numbers is proposed and then with the help of proposed product, a new method (named as Mehar’s method) is proposed for solving fully FLP problems. It is also shown that the fully FLP problems which can be solved by the existing methods can also be solved by the Mehar’s method. However, such fully FLP problems in which some or all the parameters are represented by unrestricted L-R flat fuzzy numbers can be solved by Mehar’s method but can not be solved by any of the existing methods. 相似文献
38.
Singh Swati Bawitlung Laldingngheti Singh Munmun Kumar Chauhan Amit Padalia Rajendra Chandra Pal Anirban Verma Ram Swaroop 《Chemistry of Natural Compounds》2022,58(1):161-162
Chemistry of Natural Compounds - 相似文献
39.
Basak Karpuz 《Mathematical Methods in the Applied Sciences》2019,42(9):2993-3001
In this paper, we give new sufficient conditions for both oscillation and nonoscillation of the delay dynamic equation where and satisfy τ(t) ≤ σ(t) for all large t and . As an important corollary, we obtain the time scale invariant integral condition for nonoscillation: for all large t. Also, with some examples, we show that newly presented results are sharp. 相似文献
40.
Basak Anirban Sadhu Arindam Das Kunal Sharma Kapil K. 《International Journal of Theoretical Physics》2019,58(9):3158-3179
In this paper, an attempt is made to present a method of quantum cost minimization or optimization technique for quantum reversible circuits using proposed merger rules in Exclusive Sum of Product (ESOP) method. These modified ESOP methods are used to minimize the quantum circuits. We found that the quantum cost is drastically decreased than the previous ESOP method. It will be easy to find the quantum cost and quantum gate optimized quantum circuits implementation. It will also reduce quantum error while the quantum circuit is executed in real quantum processor.
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