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Volckova E Evanics F Yang WW Bose RN 《Chemical communications (Cambridge, England)》2003,(10):1128-1129
The helix-turn-helix motifs of the DNA binding domains of human polymerase-alpha and polymerase-kappa are dramatically perturbed upon binding to cisplatin with concomitant release of zinc. 相似文献
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High-Quality Protein Crystal Growth of Mouse Lipocalin-Type Prostaglandin D Synthase in Microgravity
Inaka K Takahashi S Aritake K Tsurumura T Furubayashi N Yan B Hirota E Sano S Sato M Kobayashi T Yoshimura Y Tanaka H Urade Y 《Crystal growth & design》2011,11(6):2107-2111
Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) catalyzes the isomerization of PGH(2) to PGD(2) and is involved in the regulation of pain and of nonrapid eye movement sleep and the differentiation of male genital organs and adipocytes, etc. L-PGDS is secreted into various body fluids and binds various lipophilic compounds with high affinities, acting also as an extracellular transporter. Mouse L-PGDS with a C65A mutation was previously crystallized with citrate or malonate as a precipitant, and the X-ray crystallographic structure was determined at 2.0 ? resolution. To obtain high-quality crystals, we tried, unsuccessfully, to crystallize the C65A mutant in microgravity under the same conditions used in the previous study. After further purifying the protein and changing the precipitant to polyethylene glycol (PEG) 8000, high-quality crystals were grown in microgravity. The precipitant solution was 40% (w/v) PEG 8000, 100 mM sodium chloride, and 100 mM HEPES-NaOH (pH 7.0). Crystals grew on board the International Space Station for 11 weeks in 2007, yielding single crystals of the wild-type L-PGDS and the C65A mutant, both of which diffracted at around 1.0 ? resolution. The crystal quality was markedly improved through the use of a high-viscosity precipitant solution in microgravity, in combination with the use of a highly purified protein. 相似文献
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As a novel extension, the Kabachnik–Fields reaction was applied to the synthesis of alkyl α‐aminomethyl‐phenylphosphinates, and the double phospha‐Mannich reaction was utilized in the preparation of bis(alkoxyphenylphosphinylmethyl)amines. A total of 27 new aminophosphinate derivatives were synthesized by the microwave‐assisted solvent‐free condensation of alkyl phenyl‐H‐phosphinates, paraformaldehyde, and primary or secondary amines. The starting P‐species were also prepared under microwave conditions. The formation of the N‐methylated aminomethyl‐phenylphosphinate by‐products was also investigated. 相似文献
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Leydi Erika Sarmiento Mildred Rodríguez Lorenzo Echevarria Vito Lubes 《Journal of solution chemistry》2010,39(10):1484-1491
The complex species formed between vanadium(III) and 1,10-phenanthroline (phen), 2,2′-bipyridine (bipy), and 8-hydroxyquinoline
(8hq) were studied in aqueous solution by means of electromotive forces measurements, emf(H), at 25 °C with 3.0 mol⋅dm−3 KCl as the ionic medium. The potentiometric data were analyzed using the least-squares computational program LETAGROP, taking
into account the hydrolytic vanadium(III) species formed in solution. Analysis of the vanadium(III)–phen system data shows
the formation of [VHL]4+, [V(OH)L]2+, [V2OL2]4+ and [V2OL4]4+ complexes. In the vanadium(III)–bipy system the [VHL]4+, [V(OH)L]2+, [V2OL2]4+ and [V2OL4]4+ complexes were observed, and in the vanadium(III)–8hq system the complexes [V(OH)L]+, [V(OH)2L], [VL2]+ and [VL3] were detected. 相似文献
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Prins-type macrocyclizations have recently emerged as a successful strategy in the synthesis of polyketide-derived natural products. This reaction provides a concise and selective means to form tetrahydropyran-containing macrocyclic rings of varying size. A high degree of functionality within the macrocycle is tolerated and the yields for these transformations are typically good to excellent. Since the initial report of a Prins macrocyclization reaction in 1979, examples of this approach did not re-emerge until 2008. However, the use of this method in natural product synthesis has rapidly gained momentum in the synthetic community, with multiple examples of this macrocyclization tactic reported in the recent literature. 相似文献
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