Synthesis of 6-substituted-4-hydroxy-2-pyridinones via intramolecular ketene trapping of functionalized enamine-dioxinones

The synthesis of various 6-substituted-4-hydroxy-2-pyridinones is reported. The functionalized keto-dioxinones were constructed via a diethylzinc mediated crossed Claisen condensation reaction and subsequent enamine formation, thermolysis, and cyclization-aromatization providing the pyridinone unit.     

Biomimetic total synthesis of angelicoin A and B via a palladium-catalyzed decarboxylative prenylation-aromatization sequence

Five-step total syntheses of angelicoin A and B from 2,2,6-trimethyl-4-dioxinone are reported using late stage biomimetic aromatization reactions via diketo-dioxinones as intermediates. In addition, with angelicoin A, this aromatization was coupled with a palladium-catalyzed decarboxylative prenylation in a one-pot sequence as the key step.     

Separation of parasites from human blood using deterministic lateral displacement

We present the use of a simple microfluidic technique to separate living parasites from human blood. Parasitic trypanosomatids cause a range of human and animal diseases. African trypanosomes, responsible for human African trypanosomiasis (sleeping sickness), live free in the blood and other tissue fluids. Diagnosis relies on detection and due to their often low numbers against an overwhelming background of predominantly red blood cells it is crucial to separate the parasites from the blood. By modifying the method of deterministic lateral displacement, confining parasites and red blood cells in channels of optimized depth which accentuates morphological differences, we were able to achieve separation thus offering a potential route to diagnostics.     

Measurement of the branching fraction of Gamma(4S) --> B0B0

We report the first measurement of the branching fraction f(00) for Gamma(4S) --> B(0)B(0). The data sample consists of 81.7 fb(-1) collected at the Gamma(4S) resonance with the BABAR detector at the SLAC PEP-II asymmetric-energy e(+)e(-) storage ring. Using partial reconstruction of the decay B(0) --> D(*+) l(-)nu(l) in which only the charged lepton and the soft pion from the decay D(*+) --> D(0)pi(+) are reconstructed, we obtain f(00) = 0.487 +/- 0.010(stat) +/- 0.008(syst). Our result does not depend on the branching fractions of B(0) --> D(*+)l(-)nu(l) and D(*+) --> D(0)pi(+) decays, on the ratio of the charged and neutral B meson lifetimes, nor on the assumption of isospin symmetry.     

ITQ-12: a new microporous silica polymorph potentially useful for light hydrocarbon separations

The new synthetic form of microporous crystalline silica, denoted as ITQ-12, shows a high potential for the separation of propane and propene from its mixtures.     

Parametric approximation of isotropic and anisotropic elastic flow for closed and open curves

Deckelnick and Dziuk (Math. Comput. 78(266):645–671, 2009) proved a stability bound for a continuous-in-time semidiscrete parametric finite element approximation of the elastic flow of closed curves in \mathbbR^d, d 3 2{\mathbb{R}^d, d\geq2} . We extend these ideas in considering an alternative finite element approximation of the same flow that retains some of the features of the formulations in Barrett et al. (J Comput Phys 222(1): 441–462, 2007; SIAM J Sci Comput 31(1):225–253, 2008; IMA J Numer Anal 30(1):4–60, 2010), in particular an equidistribution mesh property. For this new approximation, we obtain also a stability bound for a continuous-in-time semidiscrete scheme. Apart from the isotropic situation, we also consider the case of an anisotropic elastic energy. In addition to the evolution of closed curves, we also consider the isotropic and anisotropic elastic flow of a single open curve in the plane and in higher codimension that satisfies various boundary conditions.     

Novel structural phases of Dy thin films on W(1 1 2)

Thin films of the rare-earth metal Dy were grown on W(1 1 2) at room temperature and 570 K. Then the resultant film morphologies were characterised by LEED and STM. A series of novel film morphologies, including c(4 × 6), c(5 × 12) and (5 × 8) structures, were found that are unique among the rare-earth metals. High thermal stability was found for the Dy films (up to 1650 K, close to the melting point at 1685 K) such that the Dy atoms preserved an ordered structure and the Dy volatility was less than would be expected from its vapour pressure. This is an indication of strong electronic interactions between the Dy atoms and the W(1 1 2) substrate.     

The role of optimum dielectric saturation in the reversible combination of oxygen with heme Fe2+ and the tuning of paramagnetic-diamagnetic switching

The paramagnetic-diamagnetic switching mechanism of hemoglobin, triggered by oxygen binding, is studied by a formalism involving an expression of work necessary to polarize the dielectric in Landau form. The “tuning” of the mechanism, or determination of occurrence of the switching in response to a certain input energy, is brought about by dielectric saturation of the medium. The relation between the effect of dielectric saturation of the medium and the effect of application of a constant (nonordering) magnetic field indicates charge transfer between the central Fe²⁺ ion and the porphyrin ring during switching.