Influence of hydrolysis method on the sol-gel formation of the yttria-alumina system with use of alcoholates

The influence exerted by hydrolysis methods and introduction of a hydrolyzing agent into the systems formed by the alkoxide technology, which uses yttrium salts and alumium secondary butylate as the initial components, was determined. It was found that the hydrolysis stage affects the conditions of the subsequent thermal treatment, the phase formation in the system, and the granulometric composition of the prepared powders. The most favorable conditions for formation of yttrium aluminum garnet are achieved upon excess water hydrolysis in the presence of an aqueous solution of yttrium salt.     

Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity

The application of non-planar scaffolds in drug design allows for the enlargement of the chemical space, and for the construction of molecules that have more effective target–ligand interactions or are less prone to the development of resistance. Among the works of the last decade, a literature search revealed spirothiazamenthane, which has served as a lead in the development of derivatives active against resistant viral strains. In this work, we studied the novel molecular scaffold, which resembles spirothiazamenthane, but combines isoxazoline as a heterocycle and cyclooctane ring as a hydrophobic part of the structure. The synthesis of new 3-nitro- and 3-aminoisoxazolines containing spiro-fused or 1,2-annelated cyclooctane fragments was achieved by employing 1,3-dipolar cycloaddition of 3-nitro-4,5-dihydroisoxazol-4-ol 2-oxide or tetranitromethane-derived alkyl nitronates with non-activated alkenes. A series of spiro-sulfonamides was obtained by the reaction of 3-aminoisoxazoline containing a spiro-fused cyclooctane residue with sulfonyl chlorides. Preliminary screening of the compounds for antiviral, antibacterial, antifungal and antiproliferative properties in vitro revealed 1-oxa-2-azaspiro[4.7]dodec-2-en-3-amine and 3a,4,5,6,7,8,9,9a-octahydrocycloocta[d]isoxazol-3-amine with activity against the influenza A/Puerto Rico/8/34 (H1N1) virus in the submicromolar range, and high values of selectivity index. Further study of the mechanism of the antiviral action of these compounds, and the synthesis of their analogues, is likely to identify new agents against resistant viral strains.     

A bound for the coefficient c4 for one-sheeted functions in terms of ¦c2¦

In the class S of functions which are regular and single-sheeted in the circle ¦z¦ < 1, the bound for ¦c₄¦ in terms of ¦c₂¦, obtained by Al'fors, is improved. The crudest bound ¦c₄¦ –< 4/15 (11 + ¦c₂¦) is better than that of Al'fors: ¦c₄¦ –< Translated from Matematicheskie Zametki, Vol. 12, No. 2, pp. 127–130, August, 1972.     

Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections

Russian Chemical Bulletin - N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using...     

泥沙输运模拟综述——现状及其发展趋势

随着流体力学中数值方法的飞速发展,计算模型已经成为研究流体运动,泥沙输运和不同环境(诸如河流,湖泊及沿海地区)中相应污染物归趋过程等方面非常有吸引力的工具,在过去的30多年里,发展了许多计算水动力学/泥沙输运模型.文章追溯当前具有代表性的(一维、二维、三维)模型的发展历程,描述他们各自的特点,优势及局限,力图作为对模型方面感兴趣读者的第一指南,同时也为大家讨论模型的局限性,未来的发展趋势和研究需求方面搭建一个平台.给出了模型的表达,时空特性,水动力学和沉积物的耦合方式,处理非恒定流,推移质和悬移质,泥沙交换过程,泥沙类型(粘性或非粘性)及非均匀泥沙输运的能力.总结了不同模型的应用实例,读者可以运用这些例子作为研究模型设置,模型率定及模型验证的参考.给出了选择泥沙输运模型应遵循的原则,模型输入及率定方面存在的问题及改进的途径.探讨了现有水动力学/泥沙输运模型在处理复杂湍流,泥沙携带,流动与输沙耦合,非均匀泥沙,离散和扩散系数,河岸来沙处理等方面的局限性及改进的方向.最后,对基于多相流思想的泥沙输运模型及其它一些交叉性问题作了评述与展望.