全文获取类型
收费全文 | 278921篇 |
免费 | 2293篇 |
国内免费 | 963篇 |
专业分类
化学 | 125348篇 |
晶体学 | 4064篇 |
力学 | 15856篇 |
综合类 | 5篇 |
数学 | 53494篇 |
物理学 | 83410篇 |
出版年
2021年 | 1657篇 |
2020年 | 1797篇 |
2019年 | 2001篇 |
2018年 | 12860篇 |
2017年 | 12571篇 |
2016年 | 9667篇 |
2015年 | 3119篇 |
2014年 | 3885篇 |
2013年 | 9392篇 |
2012年 | 10838篇 |
2011年 | 18799篇 |
2010年 | 11461篇 |
2009年 | 11729篇 |
2008年 | 14239篇 |
2007年 | 16448篇 |
2006年 | 7895篇 |
2005年 | 8103篇 |
2004年 | 7879篇 |
2003年 | 7534篇 |
2002年 | 6449篇 |
2001年 | 6643篇 |
2000年 | 5192篇 |
1999年 | 3919篇 |
1998年 | 3209篇 |
1997年 | 3173篇 |
1996年 | 2984篇 |
1995年 | 2728篇 |
1994年 | 2539篇 |
1993年 | 2428篇 |
1992年 | 2748篇 |
1991年 | 2734篇 |
1990年 | 2648篇 |
1989年 | 2456篇 |
1988年 | 2511篇 |
1987年 | 2510篇 |
1986年 | 2339篇 |
1985年 | 3009篇 |
1984年 | 3261篇 |
1983年 | 2671篇 |
1982年 | 2845篇 |
1981年 | 2811篇 |
1980年 | 2683篇 |
1979年 | 2777篇 |
1978年 | 2862篇 |
1977年 | 2840篇 |
1976年 | 2905篇 |
1975年 | 2691篇 |
1974年 | 2660篇 |
1973年 | 2804篇 |
1972年 | 1780篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
42.
Functional Binding Surface of a β‐Hairpin VEGF Receptor Targeting Peptide Determined by NMR Spectroscopy in Living Cells
下载免费PDF全文
![点击此处可从《Chemistry (Weinheim an der Bergstrasse, Germany)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Dr. Donatella Diana Anna Russomanno Dr. Lucia De Rosa Dr. Rossella Di Stasi Dr. Domenica Capasso Dr. Sonia Di Gaetano Dr. Alessandra Romanelli Dr. Luigi Russo Dr. Luca D. D'Andrea Prof. Roberto Fattorusso 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(1):91-95
In this study, the functional interaction of HPLW peptide with VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) was determined by using fast 15N‐edited NMR spectroscopic experiments. To this aim, 15N uniformly labelled HPLW has been added to Porcine Aortic Endothelial Cells. The acquisition of isotope‐edited NMR spectroscopic experiments, including 15N relaxation measurements, allowed a precise characterization of the in‐cell HPLW epitope recognized by VEGFR2. 相似文献
43.
44.
45.
S. D. Campos 《中国物理C(英文版)》2020,44(10):103103-103103-10
This work presents the subtraction procedure and the Regge cut in the logarithmic Regge pole approach. The subtraction mechanism leads to the same asymptotic behavior as previously obtained in the non-subtraction case. The Regge cut, in contrast, introduces a clear role to the non-leading contributions for the asymptotic behavior of the total cross-section. From these results, some simple parameterization is introduced to fit the experimental data for the proton-proton and antiproton-proton total cross-section above some minimum value up to the cosmic-ray. The fit parameters obtained are used to present predictions for the \begin{document}$ \rho(s)$\end{document}
-parameter as well as to the elastic slope \begin{document}$ B(s)$\end{document}
at high energies. 相似文献
46.
The serine protease, DegP exhibits proteolytic and chaperone activities, essential for cellular protein quality control and normal cell development in eukaryotes. The P. falciparum DegP is essential for the parasite survival and required to combat the oscillating thermal stress conditions during the infection, protein quality checks and protein homeostasis in the extra-cytoplasmic compartments, thereby establishing it as a potential target for drug development against malaria. Previous studies have shown that diisopropyl fluorophosphate (DFP) and the peptide SPMFKGV inhibit E. coli DegP protease activity. To identify novel potential inhibitors specific to PfDegP allosteric and the catalytic binding sites, we performed a high throughput in silico screening using Malaria Box, Pathogen Box, Maybridge library, ChEMBL library and the library of FDA approved compounds. The screening helped identify five best binders that showed high affinity to PfDegP allosteric (T0873, T2823, T2801, , CD00811) and the catalytic binding site (T0078L, T1524, T2328, BTB11534 and 552691). Further, molecular dynamics simulation analysis revealed RJC02337, BTB11534 as the best hits forming a stable complex. WaterMap and electrostatic complementarity were used to evaluate the novel bio-isosteric chemotypes of RJC02337, that led to the identification of 231 chemotypes that exhibited better binding affinity. Further analysis of the top 5 chemotypes, based on better binding affinity, revealed that the addition of electron donors like nitrogen and sulphur to the side chains of butanoate group are more favoured than the backbone of butanoate group. In a nutshell, the present study helps identify novel, potent and Plasmodium specific inhibitors, using high throughput in silico screening and bio-isosteric replacement, which may be experimentally validated. RJC02337相似文献
47.
Mathematical Notes - We study the multiplicity of weak solutions to the boundary-value problem $$\begin{alignedat}{2} - M\biggl(\iint_{\mathbb R^{2N}}|u(x)-u(y)|^2 K(x-y)\,d x\,d y\biggr)\mathscr... 相似文献
48.
49.
Periodica Mathematica Hungarica - We present a tight parametrical Hermite–Hadamard type inequality with probability measure, which yields a considerably closer upper bound for the mean value... 相似文献
50.
Mathematical Notes - It is proved that the lattice of all Fitting classes of finite groups is not distributive, and conditions under which Fitting classes satisfy the distributive and modular laws... 相似文献