Measurement of the muon capture rate in hydrogen gas and determination of the proton's pseudoscalar coupling gP

The rate of nuclear muon capture by the proton has been measured using a new technique based on a time projection chamber operating in ultraclean, deuterium-depleted hydrogen gas, which is key to avoiding uncertainties from muonic molecule formation. The capture rate from the hyperfine singlet ground state of the microp atom was obtained from the difference between the micro(-) disappearance rate in hydrogen and the world average for the micro(+) decay rate, yielding Lambda(S)=725.0+/-17.4 s(-1), from which the induced pseudoscalar coupling of the nucleon, g(P)(q(2)=-0.88m(2)(micro))=7.3+/-1.1, is extracted.     

Urological malignancies and the proteomic-genomic interface

The urological malignancies, renal, bladder and prostate cancer, account for approximately 16% of all cancer cases. Unfortunately 5-year survival rates are relatively poor, largely a result of many cases not being diagnosed before the tumour has metastasised. There is a clear need for the identification of markers which will allow earlier detection of disease, and predict prognosis and response to therapy. In addition, they may be of use as therapeutic targets. Current advances in molecular biology are allowing the identification of a number of tumour-associated changes which could be of clinical use in the future. However, with the rapid technological advances being made in the field of proteomics, this approach could be integrated with genomics providing a complementary alternative, overcoming disparities between mRNA levels and protein production, and additionally allowing the identification of tumour-associated post-translational modifications. These approaches have already been used to identify novel genes and other cancer-related changes involved in the pathogenesis of urological malignancies. This review describes current progress in the genomic and proteomic study of urological malignancies, and highlights the potential of using proteomic technologies in the study of this group of diseases.     

A new synthesis of indolo[2,3-α]quinolizidine derivatives: a formal total synthesis of (±)-geissoschizine

A stereospecific elimination process has been developed for introducing the E-ethylidene group in a transformation of tryptamine into methyl (±)-geissoschizoate.     

Reversible dimethylamine addition as a protecting reaction for α,β-unsaturated methylene groups of γ-lactones and its regeneration by basic elimination of quaternary ammonium salts: A convenient synthesis of dehydrosaussurea lactone

The blocking and deblocking sequence pertaining to the α,β-unsaturated methylene γ-lactone unit of costunolide is described. Utilizing this approach a simple and practical synthesis of dehydrosaussurea lactone is reported.     

Nosonomy of an upside down hierarchy model (I)

We study the possibility of incorporating Witten's inverse hierarchy mechanism into a phenomenologically viable grand unified model. Various severe difficulties are pointed out.     

The basis number of the n-cube

The basis number of a graph G is defined as the least integer k such that G has a k-fold basis for its cycle space. MacLane (Fund. Math.28 (1937), 22–32) has shown that a graph is planar if and only if its basis number is ≤2. The basis numbers of certain classes of nonplanar graphs have been previously investigated. The basis number of the n-cube for every n is determined in the paper.     

On the norm of an idempotent Schur multiplier on the Schatten class

We show that if the norm of an idempotent Schur multiplier on the Schatten class lies sufficiently close to , then it is necessarily equal to . We also give a simple characterization of those idempotent Schur multipliers on whose norm is .

     

Investigation of modified basal plane pyrolytic graphite electrodes: definitive evidence for the electrocatalytic properties of the ends of carbon nanotubes

The basis of the electrocatalytic nature of multi-wall carbon nanotubes is suggested to reside in electron transfer from the ends of nanotubes, which structurally resemble the behaviour of edge plane (as opposed to basal plane) graphite, and is demonstrated via the comparison of the electrochemical oxidation of epinephrine and the electrochemical reduction of ferricyanide at nanotube-modified electrodes using different types of graphite electrodes and with C(60)-modified electrodes.